Chromosome 12 Open Reading Frame 39 (C12orf39) Kits ELISA

Induces contraction of stomach muscle (By similarity).

list all ELISA KIts Gène GeneID UniProt
C12orf39 80763 Q9BT56
Anti-Rat C12orf39 C12orf39 691138  
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Humain 15.6 pg/mL 62.5-4000 pg/mL Typical standard curve 96 Tests 15 to 18 Days

Chromosome 12 Open Reading Frame 39 Kits ELISA mieux référencés

  1. Human C12orf39 Kit ELISA pour Sandwich ELISA - ABIN830436 : Gu, Ma, Gu, Zhang, Yan, Li, Wang, Ding, Yin, Fan, Peng: Spexin peptide is expressed in human endocrine and epithelial tissues and reduced after glucose load in type 2 diabetes. dans Peptides 2015 (PubMed)

Plus Kits ELISA pour Chromosome 12 Open Reading Frame 39 partenaires d'interaction

Human Chromosome 12 Open Reading Frame 39 (C12orf39) interaction partners

  1. SPX is a novel regulator of lipid metabolism in murine 3T3-L1 and human adipocytes.

  2. Lower circulating levels of SPX in adults are modestly associated with components of metabolic syndrome and are sex-specific.

  3. Data suggest that, in response to oral glucose (as in oral glucose tolerance test), adolescent serum spexin levels are not significantly correlated with body composition, fitness, or blood biochemical measurements; these studies were conducted in adolescents with either healthy normal weight, obesity, type 2 diabetes, or obesity plus type 2 diabetes.

  4. Serum levels of both spexin and kisspetin show negative correlation with obesity and insulin resistance in women.

  5. Lower circulating levels of Spexin in obese children compared with their normal-weight counterparts and the ability to discriminate obese and normal-weight groups based on Spexin concentration enabled us to suggest a potential role for this novel peptide in childhood obesity.

  6. The results suggest that C12orf39, CSTA, and CALCB are novel ATF4 target genes, and that C12orf39 promoter activity is activated by ATF4 through amino acid response element.

  7. Circulating spexin levels are low in T2DM patients and negatively related to blood glucose and lipids suggesting that the peptide may play a role in glucose and lipid metabolism in T2DM.

  8. Data from ligand-receptor interaction studies suggest that human spexin-1 and zebrafish spexin-2 activate galanin receptors GALR2/GALR3 (but not GALR1); thus spexins appear to be natural ligands for human/Xenopus/zebrafish GALR2/GALR3.

  9. newly identified peptides derived from the NPQ/spexin precursor contribute to CNS-mediated control of arterial blood pressure and salt and water balance and modulate nociceptive responses

  10. Taken together, although C12ORF39 is not a secreted small peptide, it can also be secreted to play a role in the biological functions of the placenta.

Chromosome 12 Open Reading Frame 39 (C12orf39) profil antigène

Antigen Summary

Induces contraction of stomach muscle (By similarity).

Gene names and symbols associated with C12orf39

  • spexin hormone (SPX) anticorps
  • spexin hormone (Spx) anticorps
  • Npq anticorps
  • Spx anticorps

Protein level used designations for C12orf39

NPQ , neuropeptide Q , spexin , LRRGT00060

80763 Homo sapiens
509493 Bos taurus
691138 Rattus norvegicus
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