anti-Cullin 4A (CUL4A) Anticorps

CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009].. De plus, nous expédions Cullin 4A Protéines (4) et et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
CUL4A 8451 Q13619
CUL4A 99375 Q3TCH7
CUL4A 361181  
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Top anti-Cullin 4A Anticorps sur anticorps-enligne.fr

Showing 10 out of 94 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB Host: Rabbit  Target Name: CUL4A  Sample Tissue: Human Fetal Lung  Antibody Dilution: 1.0 µg/mL 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué IP, WB Immunohistochemistry.  anti-CUL4 antibody was diluted 1:500 to detect CUL4 in human testes tissue. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counter stain. 100 μL Connectez-vous pour afficher 7 to 9 Days
$389.00
Détails
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p), IP, PLA, WB Immunohistochemistry-Paraffin: Cullin 4a Antibody [ABIN250653] - Human breast carcinoma (left) and mouse squamous cell carcinoma (right). Antibody used at a dilution of 1:1000 (1ug/ml). 0.1 mL Connectez-vous pour afficher 7 to 9 Days
$556.31
Détails
Humain Lapin Inconjugué WB Western blot analysis of CUL4A (arrow) using rabbit polyclonal CUL4A Antibody (N-term) (ABIN657794). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CUL4A gene. 400 μL Connectez-vous pour afficher 10 to 11 Days
$335.50
Détails
Humain Lapin Inconjugué WB Western blot analysis of CUL4a (arrow) using rabbit polyclonal CUL4a Antibody (Human N-term) (ABIN391852).293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the CUL4a gene (Lane 2) (Origene Technologies). 400 μL Connectez-vous pour afficher 10 to 11 Days
$335.50
Détails
Humain Lapin Inconjugué ELISA, IHC, IHC (p), WB Immunohistochemistry-Paraffin: Cullin 4a Antibody [NBP1-78040] - anti-CUL4 antibody was diluted 1:500 to detect CUL4 in human testes tissue. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. 0.1 mL Connectez-vous pour afficher 7 to 9 Days
$585.06
Détails
Humain Lapin Inconjugué IHC, WB 100 μL Connectez-vous pour afficher 16 Days
$334.02
Détails
Humain Lapin Inconjugué ELISA, IHC, IHC (p), IP, WB Human Testis (formalin-fixed, paraffin-embedded) stained with CUL4A antibody ABIN218509 at 1:500 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-CUL4A / Cullin 4A antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500. 50 μL Connectez-vous pour afficher 11 to 14 Days
$484.00
Détails
Humain Lapin Inconjugué ELISA, IHC, WB   100 μL Connectez-vous pour afficher 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué WB CUL4A MaxPab rabbit polyclonal antibody. Western Blot analysis of CUL4A expression in mouse lung. CUL4A MaxPab rabbit polyclonal antibody. Western Blot analysis of CUL4A expression in human placenta. 100 μg Connectez-vous pour afficher 11 to 12 Days
$425.71
Détails

anti-Cullin 4A Anticorps mieux référencés

  1. Human Polyclonal Cullin 4A Primary Antibody pour IP, WB - ABIN233773 : Leung-Pineda, Huh, Piwnica-Worms: DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress. dans Cancer research 2009 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal Cullin 4A Primary Antibody pour ICC, IF - ABIN250653 : Jiang, Rong, Sheikh, Huang: Cullin-4A·DNA damage-binding protein 1 E3 ligase complex targets tumor suppressor RASSF1A for degradation during mitosis. dans The Journal of biological chemistry 2011 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal Cullin 4A Primary Antibody pour ELISA, IHC - ABIN6266195 : Gong, Xiang, Feng, Chen, Fang, Xiong: CUL4A promotes cell invasion in gastric cancer by activating the NF-κB signaling pathway. dans Biologics : targets & therapy 2018 (PubMed)

  4. Human Polyclonal Cullin 4A Primary Antibody pour ELISA, IHC - ABIN4300968 : Higa, Mihaylov, Banks, Zheng, Zhang: Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint. dans Nature cell biology 2003 (PubMed)

Plus d’anticorps contre Cullin 4A partenaires d’interaction

Zebrafish Cullin 4A (CUL4A) interaction partners

  1. Results show that cul4a but not cul4b (Montrer CUL4B Anticorps) is required for the expression of tbx5a, an essential transcription factor in heart and limb development.

Human Cullin 4A (CUL4A) interaction partners

  1. Results suggested that miR377 is a significant negative regulator of CUL4A that controls cancer cell progression in ovarian cancer cell lines.

  2. These results suggest that different DDB1-CUL4 associated factors play distinct roles in human lung adenocarcinoma development.

  3. The identification of CUL4A as a downstream target of TGF-beta1 (Montrer TGFB1 Anticorps) represents a critical pro-survival mechanism in breast cancer progression and provides another point for therapeutic intervention in breast cancer.

  4. Our data demonstrate that overexpression of CUL4A plays an oncogenic role in iCCA (Montrer PRRT2 Anticorps) and adversely affects disease-free survival. Thus, it may prove to be a powerful prognostic factor and a potential therapeutic target.

  5. JMJD2C (Montrer KDM4C Anticorps) regulated the activities of lung cancer cells by directly controlling the expression of CUL4A in JMJD2C (Montrer KDM4C Anticorps) over-expression cell line.

  6. plays a critical role in perihilar cholangiocarcinoma (PHCC) metastasis by facilitating PHCC cell motility and cell invasion as well as consequent induction of epithelial to mesenchymal transition via, at least partially, up-regulating transcriptional regulation factor ZEB1 (Montrer ZEB1 Anticorps)

  7. The CUL4A interacts with WD-40 proteins through the adaptor protein DNA damage-binding protein 1 (DDB1) to target substrates for ubiquitylation.

  8. knockdown of cullin 4A via small interfering RNA inhibited the proliferation of the multiple myeloma cell lines by delaying cell-cycle progression and increasing apoptosis. cullin 4A downregulation inhibited multiple myeloma cell migration and invasion in vitro. Our results suggested that cullin 4A could be a promising therapy target in multiple myeloma patients

  9. findings revealed that CUL4A and CUL4B (Montrer CUL4B Anticorps) are differentially associated with etiologic factors for pulmonary malignancies and are independent prognostic markers for the survival of distinct lung cancer subtypes

  10. decreased tumour growth and increased chemosensitivity to gemcitabine were also noted after Cul4A knockdown.

Mouse (Murine) Cullin 4A (CUL4A) interaction partners

  1. These studies identify CUL4-DDB1 complex as a novel post-translational regulator of stem and progenitor maintenance and differentiation.

  2. CUL4A facilitates hepatocarcinogenesis by promoting cell cycle progression and epithelial-mesenchymal transition.

  3. Findings indicate that Cul4A is oncogenic in vivo and that Cul4A over-expression is associated with cisplatin resistance in lung cancer cells.

  4. this study revealed an indispensable role for Cul4a during male germ cell meiosis.

  5. The primary spermatocytes in Cul4A-/- mice are deficient in progression through late prophase I, a time point when expression of the X-linked Cul4B (Montrer CUL4B Anticorps) gene is silenced due to meiotic sex chromosome inactivation.

  6. CUL-4A is critical for early embryonic development. CUL-4A(-/-) embryos die between 4.5 and 7.5 dpc.

  7. Enforced CUL-4A expression does not alter the cell cycle distribution of uninduced cells. It increases the proportion of induced cells in S-phase & reduces the proportion in G0/G1. This CUL-4A regulatory function is interconnected with differentiation.

  8. a Cul4A ubiquitin ligase (Montrer RNF123 Anticorps) positively regulates proliferation by targeting p27 (Montrer CDKN1B Anticorps) for degradation and that Cul4A down-regulation during terminal erythroid differentiation allows p27 (Montrer CDKN1B Anticorps) to accumulate and signal cell cycle exit

  9. Cul4A(+/-) hematopoietic stem-cells exhibit defects in engraftment and self-renewal capacity

  10. Cul4A deficiency resulted in DNA damage and apoptosis of rapidly dividing cells, and mutant mice died within 3 to 10 days after induction with dramatic atrophy of the intestinal villi, bone marrow, and spleen, and with hematopoietic failure

Cullin 4A (CUL4A) profil antigène

Profil protéine

CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009

Gene names and symbols associated with anti-Cullin 4A (CUL4A) Anticorps

  • cullin 4A (CUL4A) anticorps
  • cullin 4A (cul4a) anticorps
  • cullin 4A (Cul4a) anticorps
  • 2810470J21Rik anticorps
  • AW495282 anticorps
  • CUL4A anticorps
  • RGD1563853 anticorps
  • zgc:64071 anticorps

Protein level used designations for anti-Cullin 4A (CUL4A) Anticorps

cullin 4A , cullin-4A-like , CUL-4A , cullin-4A

GENE ID SPECIES
100033930 Equus caballus
394002 Danio rerio
452694 Pan troglodytes
548647 Xenopus (Silurana) tropicalis
607683 Canis lupus familiaris
100411111 Callithrix jacchus
100453992 Pongo abelii
100470988 Ailuropoda melanoleuca
100549149 Meleagris gallopavo
100579811 Nomascus leucogenys
8451 Homo sapiens
99375 Mus musculus
361181 Rattus norvegicus
418744 Gallus gallus
100517912 Sus scrofa
617935 Bos taurus
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