anti-Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6) Anticorps

CYP2D6 encodes a member of the cytochrome P450 superfamily of enzymes.

afficher tous les anticorps Gène GeneID UniProt
Anti-Rat CYP2D6 CYP2D6 171522 Q64680
Anti-Humain CYP2D6 CYP2D6 1565 P10635
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Top anti-Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 Anticorps sur anticorps-enligne.fr

Showing 10 out of 158 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-CYP2D6 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  OVCAR-3 cell lysate CYP2D6 is strongly supported by BioGPS gene expression data to be expressed in Human OVCAR3 cells WB Suggested Anti-CYP2D6 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500 <br /> Positive Control: OVCAR-3 cell lysate <br /> CYP2D6 is strongly supported by BioGPS gene expression data to be expressed in Human OVCAR3 cells 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB Rabbit Anti-CYP2D6 Antibody  Paraffin Embedded Tissue: Human Kidney Cellular Data: Epithelial cells of renal tubule Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X WB Suggested Anti-CYP2D6 Antibody Titration:  2.5ug/ml  Positive Control:  Human Liver 100 μL Connectez-vous pour afficher 2 to 3 Days
$229.00
Détails
Humain Lapin Inconjugué IP, WB Western blot analysis of Cytochrome P450 2D6 expression in A431 (A), K562 (B), HuvEc (C) whole cell lysates. 200 μL Connectez-vous pour afficher 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué WB Western blot analysis of Cytochrome P450 2D6 expression in MCF7 (A), NIH3T3 (B), H9C2 (C) whole cell lysates. 200 μL Connectez-vous pour afficher 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué IP, WB Western blot analysis of Cytochrome P450 2D6 expression in A431 (A), K562 (B), HuvEc (C) whole cell lysates. 200 μL Connectez-vous pour afficher 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué WB Western blot analysis of Cytochrome P450 2D6 expression in MCF7 (A), NIH3T3 (B), H9C2 (C) whole cell lysates. 200 μL Connectez-vous pour afficher 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué ELISA, WB Western blot analysis of extracts from 293/HuvEc/MCF-7 cells, using Cytochrome P450 2D6 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Connectez-vous pour afficher 2 to 3 Days
$302.50
Détails
Humain Lapin Inconjugué ELISA, WB Western blot analysis of extracts from HT-29 cells, using Cytochrome P450 2D6 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Connectez-vous pour afficher 2 to 3 Days
$302.50
Détails
Humain Lapin Inconjugué WB   200 μL Connectez-vous pour afficher 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué IHC (p), WB Western blot analysis of Cytochrome P450 2D6 using anti- Cytochrome P450 2D6 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: rat liver tissue lysates,   Lane 2: mouse liver tissue lysates. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti- Cytochrome P450 2D6 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for Cytochrome P450 2D6 at approximately 56KD. The expected band size for Cytochrome P450 2D6 is at 56KD. IHC analysis of Cytochrome P450 2D6 using anti- Cytochrome P450 2D6 antibody . Cytochrome P450 2D6 was detected in paraffin-embedded section of mouse intestine tissues. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti- Cytochrome P450 2D6 Antibody  overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen. 100 μg Connectez-vous pour afficher 4 to 6 Days
$280.00
Détails

anti-Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 Anticorps mieux référencés

  1. Human Polyclonal CYP2D6 Primary Antibody pour IHC (p), WB - ABIN658441 : Gao, Zhang, Cui, Akinyi: Comparison of Paeoniflorin and Albiflorin on Human CYP3A4 and CYP2D6. dans Evidence-based complementary and alternative medicine : eCAM 2015 (PubMed)

Plus d’anticorps contre Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 partenaires d’interaction

Human Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6) interaction partners

  1. TAM (Montrer CCNA1 Anticorps) metabolism is extremely complex and involves several drug-metabolizing enzymes. Despite having shown a clear gene-exposure effect, CYP2D6 genotype can only partially explain the interindividual variability observed in TAM (Montrer CCNA1 Anticorps) metabolite levels.

  2. Consensus has yet to be reached on which CYP2D6 and CYP2C19 (Montrer CYP2C19 Anticorps) star alleles to include on pharmacogenetic testing panels and pharmacogenetic results reporting could be considerably improved

  3. CYP2D6 polymorphisms were not associated with hypertension risk.

  4. Results found significant association of C2850T, G1846A and C100T polymorphisms of CYP2D6 with coronary artery disease especially in females of North-West Indian population.

  5. This population-based study does not support the hypothesis that patients with diminished CYP2D6 activity achieve inferior tamoxifen benefit. These contradictory findings suggest that the association between CYP2D6 genotype and tamoxifen treatment efficacy is null or near null, and unlikely to be useful in clinical practice.

  6. The study results indicated the good response pattern was influenced by the concentration of donepezil, but not by APOE (Montrer APOE Anticorps) and CYP2D6 polymorphisms.

  7. tamoxifen biotransformation to endoxifen is highly dependent on CYP2D6 activity; however, it is unclear whether there is an association between CYP2D6 genotype or endoxifen concentration and tamoxifen efficacy.

  8. even though the available recommendations are against the CYP2D6 screening, the negative results of clinical trials may have been biased by issues in data collection, analysis and interpretation.

  9. CYP2D6 protein and activity levels did not differ significantly between the genotypes (CYP2D6*1/*1, *1/*10, and *10/*10 genotypes) in the small intestine of the Japanese population.

  10. genetic association studies in Chinese population: Data suggest that genetic polymorphisms and mutations in CYP2D6 are associated with alterations in metabolism of the anti-hemangioma medication hemangeol; some genetic alterations exclude hemangeol as a substrate for CYP2D6.

Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6) profil antigène

Profil protéine

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug\; sparteine and propafenone, both anti-arrythmic drugs\; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population\; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CYP2D6

  • cytochrome 2D6 (CYP2D6) anticorps
  • cytochrome P450 2D6 (CYP2D6) anticorps
  • cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6) anticorps
  • cytochrome P450, family 2, subfamily D, polypeptide 6 (cyp2d6-b) anticorps
  • cytochrome P450 family 2 subfamily D member 6 S homeolog (cyp2d6.S) anticorps
  • cytochrome P450 family 2 subfamily D member 6 (cyp2d6) anticorps
  • cytochrome P450, family 2, subfamily d, polypeptide 4 (Cyp2d4) anticorps
  • cytochrome P450 family 2 subfamily D member 6 (CYP2D6) anticorps
  • cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D14) anticorps
  • CPD6 anticorps
  • CYP2D anticorps
  • cyp2d2 anticorps
  • Cyp2d4v1 anticorps
  • Cyp2d4v2 anticorps
  • CYP2D6 anticorps
  • cyp2d6-a anticorps
  • CYP2D7AP anticorps
  • CYP2D7BP anticorps
  • CYP2D7P2 anticorps
  • CYP2D8P2 anticorps
  • Cyp2d18 anticorps
  • Cyp2d22 anticorps
  • CYP2D42 anticorps
  • CYP2DL1 anticorps
  • CYPIID6 anticorps
  • MGC64445 anticorps
  • P450-DB1 anticorps
  • P450C2D anticorps
  • P450DB1 anticorps

Protein level used designations for CYP2D6

cytochrome P450 2D6 , cytochrome P450 CYP2D42 , cytochrome P450, family 2, subfamily D, polypeptide 6 , CYPIID18 , CYPIID4 , Cytochrome P450, subfamily IID4 , P450 2D-29/2D-35 , P450-CMF3 , P450-DB4 , cytochrome P450 2D-29 , cytochrome P450 2D-35 , cytochrome P450 2D4 , cytochrome P450 2d18 , cytochrome P450, family 2, subfamily d, polypeptide 22 , cytochrome P450, subfamily 2D, polypeptide 6 , cytochrome P450, subfamily IID, polypeptide 6 , cytochrome P450-CMF3 , cytochrome P450-DB4 , debrisoquine 4-hydroxylase , cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2 , cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2 , cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2 , cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2 , cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6 , cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1 , cytochrome P450-DB1 , flavoprotein-linked monooxygenase , microsomal monooxygenase , xenobiotic monooxygenase , CYPIID14 , cytochrome P450 2D14 , CYPIID6

GENE ID SPECIES
100500743 Felis catus
100568286 Ovis aries
678691 Macaca mulatta
379479 Xenopus laevis
446878 Xenopus laevis
548436 Xenopus (Silurana) tropicalis
171522 Rattus norvegicus
1565 Homo sapiens
282211 Bos taurus
470228 Pan troglodytes
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