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DTL Protéines

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis.

3 Résultats:

Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL) (AA 1-730) protein (His tag) Protein

DTL Origine: Humain Source: Cellules d'insectes Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
N° du produit ABIN3092255
$15,464.90
Plus frais de port $45.00 et $24.00 pour carboglace
1 mg (More quantities available)
local_shipping Destination: Etats-Unis
Envoi sous 70 jours ouvrables

Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL) (AA 1-729) protein (His tag) Protein

DTL Origine: Souris Source: Cellules d'insectes Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
N° du produit ABIN3134980
$15,464.90
Plus frais de port $45.00 et $24.00 pour carboglace
1 mg (More quantities available)
local_shipping Destination: Etats-Unis
Envoi sous 70 jours ouvrables

Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL) protein (GST tag,His tag) Protein

DTL Origine: Humain Source: Escherichia coli (E. coli) Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, Func, PI, STD
N° du produit ABIN5505614
$302.50
Plus shipping costs $45.00
50 μg
local_shipping Destination: Etats-Unis
Envoi sous 6 à 10 jours ouvrables
  • Type Protein
    • Protein
  • Target Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
    • Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
    • Hemagglutinin (HA)
    • Ribosome Binding Factor A (RBFA)
    • Tumor Necrosis Factor alpha (TNF)
    • S-Adenosyl-Methionine Synthase (METK)
    • Interleukin 6 (IL6)
    • Interferon gamma (IFNG)
    • Hemoglobin beta (HBB)
    • Triosephosphate Isomerase 1 (TPI1)
    • Thymidylate Kinase (Tmk)
    • Interleukin 4 (IL4)
    • Interleukin 1, beta (IL1B)
    • Interleukin 2 (IL2)
    • Uracil-DNA Glycosylase (UNG)
    • Fibroblast Growth Factor 2 (Basic) (FGF2)
    • Growth Hormone 1 (GH1)
    • Lipoyl synthase lipA
    • Interleukin 10 (IL10)
    • KIT Ligand (KITLG)
    • Malate Dehydrogenase (MDH)
    • Insulin-Like Growth Factor 1 (IGF1)
    • Epidermal Growth Factor (EGF)
    • Leptin (LEP)
    • Interleukin 8 (IL8)
    • Interleukin 3 (IL-3)
    • Myoglobin (MB)
    • Queuine tRNA-Ribosyltransferase 1 (QTRT1)
    • Hemoglobin, alpha 1 (HBA1)
    • serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1)
    • phosphatidylserine Decarboxylase (PISD)
    • Interleukin 1 alpha (IL1A)
    • Prolactin (PRL)
    • CD40 Ligand (CD40LG)
    • Interleukin 13 (IL13)
    • Vascular Endothelial Growth Factor A (VEGFA)
    • Chemokine (C-X-C Motif) Ligand 12 (CXCL12)
    • Albumin (ALB)
    • Aspartate Carbamoyltransferase (PYRB)
    • Phosphoglucosamine Mutase (GLMM)
    • Porphobilinogen Deaminase (HEMC)
    • Interleukin 15 (IL15)
    • Phenylalanyl-tRNA Synthetase, alpha Subunit (FARSA)
    • beta-2-Microglobulin (B2M)
    • Chemokine (C-C Motif) Ligand 2 (CCL2)
    • Gp120
    • Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2)
    • Interleukin 33 (IL33)
    • Cytidine Monophosphate (UMP-CMP) Kinase 1, Cytosolic (CMPK1)
    • Fibroblast Growth Factor 1 (Acidic) (FGF1)
    • Adiponectin (ADIPOQ)
    • Ferrochelatase, HEMH (HEMH)
  • Application
    • ELISA
    • SDS-PAGE (SDS)
    • Western Blotting (WB)
    • Crystallization (Crys)
    • Antibody Production (AbP)
    • Functional Studies (Func)
    • Protein Interaction (PI)
    • Standard (STD)
  • Réactivité
    • Humain
    • Souris
  • Images disponible
  • Hote
    • Cellules d'insectes
    • Escherichia coli (E. coli)
  • Epitope
    • AA 1-729
    • AA 1-730
  • Conjugué
    • Inconjugué
    • His tag
    • GST tag,His tag
  • Type Proteine
    • Recombinant
  • Format
    • Liquid

Profil protéine DTL

Profil protéine

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).

Gene names and symbols associated with DTL

  • denticleless E3 ubiquitin protein ligase homolog (DTL) anticorps
  • denticleless E3 ubiquitin protein ligase (Dtl) anticorps
  • denticleless E3 ubiquitin protein ligase homolog (Dtl) anticorps
  • denticleless E3 ubiquitin protein ligase homolog S homeolog (dtl.S) anticorps
  • denticleless E3 ubiquitin protein ligase homolog (Drosophila) (dtl) anticorps
  • 2810047L02Rik anticorps
  • 5730564G15Rik anticorps
  • cb151 anticorps
  • cdt2 anticorps
  • cdt2-a anticorps
  • chunp6871 anticorps
  • dcaf2 anticorps
  • l2dtl anticorps
  • ramp anticorps
  • RGD1310439 anticorps
  • wu:fb54b02 anticorps

Protein level used designations for DTL

DDB1 and CUL4 associated factor 2 , DDB1- and CUL4-associated factor 2 , RA regulated nuclear matrix associated protein , RA-regulated nuclear matrix-associated protein , denticleless homolog , denticleless protein homolog , lethal(2) denticleless protein homolog , retinoic acid-regulated nuclear matrix-associated protein , Meth A ramp , meth A retinoic acid-regulated nuclear matrix-associated protein , retinoic-acid regulated nuclear matrix-associated protein , denticleless protein homolog A

GENE ID SPECIES
51514 Homo sapiens
76843 Mus musculus
305073 Rattus norvegicus
490279 Canis lupus familiaris
421373 Gallus gallus
735103 Xenopus laevis
539953 Bos taurus
100723475 Cavia porcellus
192314 Danio rerio

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