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EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that are encoded by the anhidrotic ectodermal dysplasia (EDA) gene. De plus, nous expédions Ectodysplasin A2 Receptor Anticorps (86) et Ectodysplasin A2 Receptor Protéines (23) et beaucoup plus de produits pour cette protéine.
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We found evidence for AR but not EDA2R as the candidate gene at the androgenetic alopecia risk locus on chromosome X.
EDA-A2 and its receptor XEDAR are overexpressed in epithelial cells of salivary glands in Sjogren's syndrome patients, in comparison with healthy individuals. The EDA-A2/XEDAR system in these cells is involved in the induction of apoptosis via CASP3 activation.
XEDAR activates the non-canonical NF-kappaB pathway.
To investigate the evolutionary history of the EDA2R/AR intergenic region, we characterized the haplotype structure of 52 of its highly differentiated SNPs. Nearly all human X chromosomes carry one of two modal haplotypes for these 52 SNPs.
The results suggest that EDA2R confers susceptibility to early onset female pattern hair loss
association in dental crowding in the Hong Kong Chinese population
A crucial role of the EDA-A2/ectodysplasin A2 (XEDAR) interaction is revealed in the p53-signaling pathway.
because no frequent variant other than rs1385699 has been reported in EDA2R in the European population, it is probable that the causative variant(s) modifies the expression of one or more flanking genes, i.e. AR and EDA2R
Results establish a major role of TRAF3 and -6 in X-linked ectodermal dysplasia receptor (XEDAR) signaling and in the process of ectodermal differentiation.
XEDAR belongs to a novel class of death receptors that lack a discernible death domain but are capable of activating apoptosis in a caspase 8- and FADD-dependent fashion
isoforms of EDA-A5 and A5',activated NF-kappaB through receptors EDAR and XEDAR
The androgen receptor gene and EDA2R are significantly associated with androgenetic alopecia.
androgen receptor/ectodysplasin A2 receptor haplotype may have a role in male pattern baldness
XEDAR is a putative tumor suppressor that could prevent malignant transformation and tumor progression by regulating apoptosis and anoikis.
EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that are encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. The protein encoded by this gene specifically binds to EDA-A2 isoform. This protein is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. Alternatively spliced transcript variants have been found for this gene.
X-linked ectodysplasin receptor
, tumor necrosis factor receptor superfamily member 27
, ectodysplasin A2 receptor
, EDA-A2 receptor
, X-linked ectodysplasin-A2 receptor
, tumor necrosis factor receptor superfamily member XEDAR
, X linked ectodysplasin receptor
, ectodysplasin A2 isoform receptor