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The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). De plus, nous expédions Fanconi Anemia Complementation Group G Kits (4) et Fanconi Anemia Complementation Group G Protéines (3) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal FANCG Primary Antibody pour IHC - ABIN966129
Liu, Lamerdin, Tucker, Zhou, Walter, Albala, Busch, Thompson: The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells. dans Proceedings of the National Academy of Sciences of the United States of America 1997
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Human Polyclonal FANCG Primary Antibody pour IHC - ABIN966130
Garcia-Higuera, Kuang, Näf, Wasik, DAndrea: Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex. dans Molecular and cellular biology 1999
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Human Monoclonal FANCG Primary Antibody pour IF, IP - ABIN560843
Hinz, Nham, Yamada, Tebbs, Salazar, Hinz, Mohrenweiser, Jones, Thompson: Four human FANCG polymorphic variants show normal biological function in hamster CHO cells. dans Mutation research 2006
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Human Polyclonal FANCG Primary Antibody pour WB - ABIN251005
Park, Ciccone, Beck, Hwang, Freie, Clapp, Lee: Oxidative stress/damage induces multimerization and interaction of Fanconi anemia proteins. dans The Journal of biological chemistry 2004
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Human Polyclonal FANCG Primary Antibody pour ELISA, WB - ABIN449536
Tomida, Itaya, Shigechi, Unno, Uchida, Ikura, Masuda, Matsuda, Adachi, Kobayashi, Meetei, Maehara, Yamamoto, Kamiya, Matsuura, Matsuda, Ikura, Ishiai, Takata: A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair. dans Nucleic acids research 2013
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Identification of the Xenopus laevis ortholog of human FANCG (xFANCG), its expression during development, and its molecular interactions with a partner protein, xFANCA
LOH may predominantly indicate copy number gains in FANCF (Montrer FANCF Anticorps) and losses in FANCG and BRIP1 (Montrer MRPL36 Anticorps). Integration of copy number data and gene expression proved difficult as the available sample sets did not overlap.
studied the impact of mutations on the function and structure of FANCG
Patients, homozygous for the FANCG founder mutation, present with severe cytopenia but progress to bone marrow failure at similar ages to other individuals affected with Fanconi anemia (Montrer PALB2 Anticorps) of heterogeneous genotype.
founder haplotype analysis of FANCG for the Korean Fanconi anemia (Montrer PALB2 Anticorps) population
A new role of FANCG in Homologous recombination repair of interstrand crosslinks through K63Ub-mediated interaction with the Rap80-BRCA1 complex.
FANCA (Montrer FANCA Anticorps) and FANCG are the major Fanconi anemia (Montrer PALB2 Anticorps) genes in the Korean population.
Areca nut extracts-induced miR (Montrer MLXIP Anticorps)-23a was correlated with a reduced FANCG expression and DSB repair, which might contribute to ANE-associated human malignancies.
sites of interaction of FANCG with ERCC1 (Montrer ERCC1 Anticorps), which is different from the region of ERCC1 (Montrer ERCC1 Anticorps) that binds to XPF (Montrer ERCC4 Anticorps)
Study of the molecular evolution of FA genes using database search methods such as PSI-BLAST suggested that FANCG may contain a known domain, and that this protein is a member of the family of tetratricopeptide repeat-containing proteins.
There is remarkably lage sequence variation in FANCG gene mutations and polymorphisms across ethnic and racial backgrounds found in the International Fanconi Anemia (Montrer PALB2 Anticorps) Registry they include IVS8-2A>G, IVS11+1G>c, 1794_1803del10, and IVS3+1G>C.
Hematopoietic stem cells of Fancg-/- mice Impaired functionality and homing.
null mutations in Fanca (Montrer FANCA Anticorps) or Fancg are fully epistatic
the FA pathway (FancG) is not involved in regulating the outcome of SHM (Montrer CNTNAP1 Anticorps) in mammals and it appears dispensable for class switch recombination
Data show that Fancd2 (Montrer FANCD2 Anticorps)(-/-) mice displayed a higher magnitude of chromosomal breakage and micronucleus formation than the wild-type or Fancg(-/-) mice.
Double-mutant Fancc (Montrer FANCC Anticorps)(-/-);Fancg(-/-) mice develop spontaneous hematologic sequelae including bone marrow failure, acute myeloid leukemia (Montrer BCL11A Anticorps), myelodysplasia and complex random chromosomal abnormalities that the single-mutant mice do not.
Fancg knockout mice presented with microcephalies and a decreased neuronal production in developing cortex and adult brain, demonstrating a critical role for Fanconi pathway in neural stem and progenitor cells during developmental and adult neurogenesis.
loss of the murine homologue of FANCG (Fancg) results in a defect in mesenchymal stem/progenitor cells proliferation and in their ability to support the adhesion and engraftment of murine syngeneic hematopoietic stem/progenitor cells in vitro or in vivo
Mice deficient in Fancg were not anemic, but showed hypogonadism, impaired fertility, and hypersensitivity to mitomycin C
FANCG is required for efficient homologous recombination-mediated repair of at least some types of DNA double-strand breaks
Fancg deeficient mouse cells display normal telomere length, normal telomerase activity, and normal chromosome end-capping
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity\; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G.
Fanconi anemia complementation group G variant 2
, DNA repair protein XRCC9
, Fanconi anemia group G protein
, X-ray repair complementing defective repair in Chinese hamster cells 9
, X-ray repair, complementing defective, in Chinese hamster, 9
, Fanconi anemia group G protein homolog