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The protein encoded by FETUB is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors.
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Increased serum fetuin-B level was significantly associated with higher risk of insulin (Montrer INS Anticorps) resistance. Common genetic variants of FETUB SNPs (rs4686434, rs6785067, and rs3733159) were significantly associated with serum fetuin-B concentrations but were not associated with insulin (Montrer INS Anticorps) resistance.
serum level of fetuin B in the control subjects was lower than it in nonalcoholic fatty liver disease patients. fetuin B correlated with diastolic blood pressure, serum alanine transaminase and triglycerides, among the controls. It suggested a potential association between serum fetuin B and the presence of NAFLD (Montrer TSC2 Anticorps).
Further studies need to elucidate factors contributing to fetuin B regulation in humans, as well as the pathophysiological significance of fetuin B upregulation in gestational diabetes
Data indicate that fetuin-B was one of the highly expressed serum proteins in acute myocardial infarction.
Reduced expression of fetuin-b led to a significant increase in the expression of lipogenic genes, thereby resulting in higher lipid levels.
serum fetuin (Montrer AHSG Anticorps) has a role in processing and transport of matrix gamma-carboxyglutamic acid protein and bone morphogenetic protein-2 (Montrer BMP2 Anticorps) in cultured human vascular smooth muscle cells
results support the hypothesis that fetuin-A (Montrer AHSG Anticorps) serum levels are associated with bone cell activity
Fetuin-B-deficient female mice are infertile due to an early block to fertilization.
Overexpression of Fetuin-B in skin squamous carcinoma cells led to suppression of tumor growth in nude mice.
The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells.
, fetuin-like protein IRL685
, fetuin beta
, fetuin phosphoprotein
, apo AI promoter B-region binding protein
, fetuin B