anti-G Protein-Coupled Receptor 81 (GPR81) Anticorps

Mouse (Murine) G Protein-Coupled Receptor 81 (GPR81) interaction partners

1. Study using Hcar1-KO mice identified the lactate receptor Hcar1 as a key regulator of Vegf (Montrer VEGFA Anticorps) and angiogenesis in the brain and as an initial mediator of cerebral effects of physical exercise.

2. lactate can induce GPR81-independent metabolic changes that modulate macrophage pro-inflammatory activation.

3. GPR81 expression increased during gestation, and peaked near labor. GPR81 is expressed in the uterus with high expression in myometrium. GPR81 mediates inflammation in the laboring uterus.

4. Results indicate that lactate may aggravated ischemic brain injury by activating GPR81 and inhibition of GPR81 protects against ischemia-induced cell death via an antiapoptosis pathway

5. Description of a GPR81 selective agonist with in vivo efficacy, inhibiting lipolysis without flushing.

6. Lactate negatively regulates TLR induction of the NLRP3 (Montrer NLRP3 Anticorps) inflammasome and production of IL1beta (Montrer IL1B Anticorps), via ARRB2 (Montrer ARRB2 Anticorps) and GPR81 in liver and pancreatic injury.

7. chronic obesity reduces GPR109A (Montrer HCAR2 Anticorps) and GPR81 expression in the adipose tissue, while acute in vitro LPS (Montrer TLR4 Anticorps) treatment increases expression of GPR109A (Montrer HCAR2 Anticorps) in adipocytes and macrophages.

8. Inflammation decreases the expression of GPR81 in adipose tissue

9. An autocrine lactate loop mediates insulin (Montrer INS Anticorps)-dependent inhibition of lipolysis through GPR81.

10. GPR81 couples to the Gi signaling pathway

Human G Protein-Coupled Receptor 81 (GPR81) interaction partners

1. The novel role of HCAR1 in development of chemoresistance in cervical carcinoma HeLa cells via ABCB1 (Montrer ABCB1 Anticorps) transporter up-regulation.

2. Findings identify GPR81 as a tumor-promoting receptor in breast cancer progression and suggest a novel mechanism that regulates GPR81-dependent activation of the PI3K (Montrer PIK3CA Anticorps)/Akt (Montrer AKT1 Anticorps) signaling axis in tumor microenvironment.

3. Activation of GPR81 decreases intracellular cAMP levels and inhibits PKA activity, leading to activation of TAZ (Montrer TAZ Anticorps) and upregulation of PD-L1 (Montrer CD274 Anticorps). This study reveals a critical role for lactate in the immune checkpoint pathway and an unexpected function of TAZ (Montrer TAZ Anticorps) in tumor evasion of the T-cell-mediated immune response.

4. Lactate receptor/HCAR1 expression in cervical carcinoma cells may contribute to the modulation of cellular DNA repair mechanisms.

5. HCA1/3 are necessary for breast cancer cells to balance lipid/fatty acid metabolism.

6. HCAR1 and monocarboxylate transporters activity is required for the L- and D-lactate-mediated enhancement of DNA repair and of HeLa cell survival.

7. Description of a GPR81 selective agonist with in vivo efficacy, inhibiting lipolysis without flushing.

8. Data support that GPR81 is important for cancer cell regulation of lactate transport mechanisms.

9. Lactate negatively regulates TLR induction of the NLRP3 (Montrer NLRP3 Anticorps) inflammasome and production of IL1beta (Montrer IL1B Anticorps), via ARRB2 (Montrer ARRB2 Anticorps) and GPR81 in liver and pancreatic injury.

10. demonstrated that the C165-E166-S167-F168 motif at the second extracellular loop is critical for GPR81 function, and the conserved six Cys (Montrer DNAJC5 Anticorps) residues at the extracellular regions are necessary for GPR81 function