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The protein encoded by GTSE1 is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. De plus, nous expédions GTSE1 Protéines (3) et GTSE1 Kits (2) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal GTSE1 Primary Antibody pour WB - ABIN526771
Cheeseman, Harry, McAinsh, Prior, Royle: Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension. dans Journal of cell science 2013
GTSE1 is expressed exclusively in late G2 and M phase. From nuclear envelope breakdown until anaphase onset, GTSE1 binds preferentially to the most stable mitotic spindle microtubules and promotes their turnover.
Results indicated for the first time that overexpression of GTSE1 was involved in the progress of HCC (Montrer FAM126A Anticorps), enhancing proliferation and promoting cell invasion in HCC (Montrer FAM126A Anticorps) cells.
GTSE1 inhibition of MCAK (Montrer KIF2C Anticorps) activity regulates the balance of MT stability that determines the fidelity of chromosome alignment, segregation, and chromosomal stability.
Study identifies GTSE1 as a biomarker for cisplatin resistance in gastric cancer cells and suggests its repressive role in cisplatin induced apoptosis making it a potential therapeutic target for better clinical management of gastric cancer patients.
GTSE1 is a microtubule plus-end tracking protein that regulates EB1 (Montrer MAPRE2 Anticorps)-dependent cell migration.
GTSE1 is overexpressed dramatically in lung cancer patients' tissues.
Data show that G2 and S-phase-expressed 1 (GTSE1) protein, a negative regulator of p53 (Montrer TP53 Anticorps), is required for G2 checkpoint recovery and that Plk1 (Montrer PLK1 Anticorps) phosphorylation of GTSE1 promotes its nuclear localization.
hGTSE-1 mediated-p21(CIP1/WAF1 (Montrer CDKN1A Anticorps)) stabilization is clearly involved in the ability of cells to counteract cytotoxicity induced by the microtubule poison paclitaxel.
GTSE-1 controls DNA damage-induced apoptosis by affecting p53 (Montrer TP53 Anticorps) function
requires an intact nuclear export signal and functional Mdm2 (Montrer MDM2 Anticorps) for the regulation of p53 (Montrer TP53 Anticorps)
The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis.
G-2 and S-phase expressed 1
, G2 and S phase-expressed protein 1
, G2 and S phase-expressed protein 1-like
, g2 and S phase-expressed protein 1-like
, protein B99 homolog
, G two S phase expressed protein 1