anti-GLE1 RNA Export Mediator Homolog (Yeast) (GLE1) Anticorps

GLE1 encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. De plus, nous expédions GLE1 RNA Export Mediator Homolog (Yeast) Protéines (7) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
GLE1 2733 Q53GS7
GLE1 362098 Q4KLN4
GLE1 74412 Q8R322
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Top anti-GLE1 RNA Export Mediator Homolog (Yeast) Anticorps sur anticorps-enligne.fr

Showing 10 out of 47 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-GLE1 Antibody Titration: 0.2-1 ug/mlPositive Control: Human Placenta 100 μL 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué ICC, IF, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: HeLa 7.5% SDS PAGE antibody diluted at 1:1000 IHC-P Image GLE1 antibody detects GLE1 protein at cytoplasm and nucleus in mouse brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse brain. GLE1 antibody , diluted at 1:500. 100 μL 3 to 4 Days
$466.18
Détails
Cheval Lapin Inconjugué WB 100 μL 11 to 14 Days
$551.83
Détails
Humain Lapin Inconjugué ELISA, IHC, IHC (p), WB Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE) 0.05 mg 11 to 14 Days
$484.00
Détails
Humain Lapin Inconjugué ELISA, IHC, IHC (p), WB Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-GLE1 / GLE1L antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 0.05 mg 11 to 14 Days
$484.00
Détails
Humain Lapin Inconjugué ELISA, WB 100 μL 2 to 3 Days
$446.88
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB   0.1 mg 4 to 8 Days
$522.50
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB   0.1 mg 4 to 8 Days
$522.50
Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB Paraformaldehyde-fixed, paraffin embedded rat testis, Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes, Blocking buffer (normal goat serum) at 37°C for 30min, Antibody incubation with GLE1 Polyclonal Antibody, Unconjugated  at 1:500 overnight at 4°C, followed by a conjugated secondary for 20 minutes and DAB staining. 100 μL 14 to 21 Days
$317.90
Détails
Humain Lapin Inconjugué ICC, IHC, IHC (p), WB   100 μL 11 to 14 Days
$537.17
Détails

Plus d’anticorps contre GLE1 RNA Export Mediator Homolog (Yeast) partenaires d’interaction

Human GLE1 RNA Export Mediator Homolog (Yeast) (GLE1) interaction partners

  1. Results found that Nup159 did not accelerate ADP release, while Gle1 actually slowed it independently of Mg(2+) which is not consistent with Nup159 acting as a nucleotide exchange factor to promote ADP release and Dbp5 ATPase cycling. Instead, in the presence of Nup159, the interaction between Gle1 and ADP-bound Dbp5 was found more reduced, suggesting that Nup159 alters the Dbp5-Gle1 to aid Gle1 release from Dbp5.

  2. Mitogen-activated protein kinases and glycogen synthase kinase 3 phosphorylate Gle1A and thereby coordinate stress granule dynamics by altering DDX3 function.

  3. preliminary data show an intriguing expression profile of Gle1, MART3 and FUS genes in Spinal muscular atrophy (SMA), and suggest a critical role of FUS protein in the SMA pathogenesis.

  4. Pathogenic variants in the GLE1 gene are rare in Chinese ALS patients.

  5. Data indicate 2 siblings with a homozygous p.I684T mutation in RNA export mediator (GLE1).

  6. These results imply that DBP5, GLE1 and IP6 have a conserved and individual function in the cytoplasmic mRNA expression. Variations in phenotype are due to the difference in each function of DBP5, GLE1 and IPPK in intracellular mRNA metabolism.

  7. We identified bi-allelic mutations in GLE1 in two unrelated individuals with motor delays, feeding difficulties, and respiratory insufficiency who survived beyond the perinatal period. Each affected child had missense variants predicted to result in amino acid substitutions near the C-terminus of GLE1 that are predicted to disrupt protein-protein interaction or GLE1 protein targeting.

  8. It was concluded that the amyotrophic lateral sclerosis-linked Gle1-c.1965-2A>C mutation generates a protein isoform capable of both Gle1A- and Gle1B-ascribed functions, and thereby uncoupled from normal mechanisms of Gle1 regulation.

  9. We also suggest that lethal congenital contracture syndrome 1 (LCCS1) and lethal arthrogryposis with anterior horn disease (LAAHD), the two AMC subtypes related to GLE1, do not have sufficient clinical or molecular differentiation to be considered allelic disorders. Rather, GLE1 mutations cause a variable spectrum of AMC severity including a non-lethal variant described herein

  10. Restoration of miR-127-3p and miR-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1, GLE1 and PDIA6.

  11. Role for Gle1A during stress granule formation and translation regulation during environmental stress responses is examined.

  12. We report the identification of the first heterozygous mutations in GLE1 ever found to be associated with amyotrophic lateral sclerosis.

  13. Lethal congenital contracture syndrome 1 and lethal arthrogryposis with anterior horn cell disease are associated with defective Gle1 function during the export of mRNA. [review]

  14. Report documents a requirement for Gle1 self-association during mRNA export and uncover molecular defects underlying a lethal human disease lethal congenital contracture syndrome-1.

  15. Dbp5, Gle1-IP6 and Nup159: a working model for mRNP export.

  16. defective zebrafish GLE1 function in human LCCS1 results in both neurogenic and non-neurogenic defects linked to the apoptosis of proliferative organ precursors

  17. The unique carboxyl-terminal 43 amino acid region of the hGle1B isoform mediates binding to the C-terminal non-phenylalanine- glycine region of the nucleoporin hCG1/NPL1.

  18. Mutations in mRNA export mediator GLE1 result in fetal motoneuron disease.

GLE1 RNA Export Mediator Homolog (Yeast) (GLE1) profil antigène

Profil protéine

This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GLE1

  • CG14749 gene product from transcript CG14749-RA (CG14749) anticorps
  • nucleoporin GLE1 (CpipJ_CPIJ014147) anticorps
  • RNA export factor Gle1 (SJAG_03847) anticorps
  • GLE1, RNA export mediator (GLE1) anticorps
  • GLE1 RNA export mediator (Gle1) anticorps
  • GLE1 RNA export mediator (yeast) (Gle1) anticorps
  • 4933405K21Rik anticorps
  • AA553313 anticorps
  • Dmel\\CG14749 anticorps
  • GLE1 anticorps
  • Gle1l anticorps
  • hGLE1 anticorps
  • LCCS anticorps
  • LCCS1 anticorps

Protein level used designations for GLE1

CG14749-PA , nucleoporin GLE1 , GLE1 RNA export mediator homolog , GLE1-like protein , GLE1-like, RNA export mediator , GLE1 RNA export mediator-like (yeast

GENE ID SPECIES
35849 Drosophila melanogaster
6047573 Culex quinquefasciatus
7050485 Schizosaccharomyces japonicus yFS275
417212 Gallus gallus
2733 Homo sapiens
362098 Rattus norvegicus
74412 Mus musculus
480704 Canis lupus familiaris
540982 Bos taurus
100172586 Pongo abelii
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