GTP Binding Protein Overexpressed in Skeletal Muscle (GEM) Kits ELISA

The protein encoded by GEM belongs to the RAD/GEM family of GTP-binding proteins. De plus, nous expédions GEM Anticorps (62) et GEM Protéines (5) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
GEM 2669 P55040
Anti-Rat GEM GEM 297902  
GEM 14579 P55041
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Humain < 0.188 ng/mL 0.313 ng/mL - 20 ng/mL   96 Tests 11 to 18 Days
Souris < 46.9 pg/mL 78 pg/mL - 5000 pg/mL   96 Tests 11 to 18 Days

Plus Kits ELISA pour GEM partenaires d'interaction

Human GTP Binding Protein Overexpressed in Skeletal Muscle (GEM) interaction partners

  1. Geminin family members are master regulators of centriole amplification and multiciliogenesis. (Review)

  2. High Geminin expression is associated with triple negative breast cancers.

  3. these data identify DUB3 and USP7 as factors that regulate DNA replication by controlling Geminin protein stability, and suggest that USP7 may be involved in Geminin dysregulation during breast cancer progression.

  4. geminin selectively couples the transcription factor forkhead box O3 (FoxO3) to HDAC3, thereby specifically facilitating FoxO3 deacetylation.

  5. summarize current information on the molecular functions of Geminin and the regulatory system for Geminin protein expression, and argue for the molecular role of Geminin in cell fate determination of hematopoietic stem cells [review]

  6. Down regulation of Gem expression was involved in the pathogenesis of hepatocellular carcinoma (HCC), and it might be a favorable independent prognostic parameter for HCC.

  7. Studies indicate that geminin expression is associated with different types of cancer.

  8. High geminin expression is associated with breast cancer.

  9. De novo GMNN mutations cause autosomal-dominant primordial dwarfism associated with Meier-Gorlin syndrome.

  10. Elevated Ki67 and geminin expression distinguish a fraction of metastatic breast carcinoma with worse prognosis.

  11. These findings demonstrate a new role of Gem/Gmip/RhoA signaling in cortical actin regulation during early mitotic stages.

  12. geminin is indispensable for fetal hematopoiesis and regulates the generation of a physiological pool of stem and progenitor cells in the fetal hematopoietic system.

  13. These findings suggest that E2F-mediated activation of Geminin transcription is negatively regulated by Geminin through the inhibition of chromatin remodeling.

  14. Bound Geminin prevents transition of the pre-replicative complexes to a state that is competent for initiation of DNA replication.

  15. Gem is involved both in T-cell spontaneous cell migration as well as chemotaxis and plays an important role in cell-to-cell HTLV-1 viral transmission.

  16. Selective expression of geminin during the proliferative phase of the cell cycle and its nuclear specificity increase its potential to be used as an alternative marker of proliferation in breast cancer patients.

  17. Protein levels of Geminin and Cdt1 are tightly regulated through the cell cycle, and the Cdt1-Geminin complex likely acts as a molecular switch that can enable or disable the firing of each origin of replication.

  18. The Aurora-A-geminin-Cdt1 axis represents a critical regulator of proper DNA replication.

  19. The properties of the Idas-Geminin complex suggest it as the functional form of Idas and provide a possible mechanism to modulate Geminin activity

  20. Human geminin, when expressed in human cells in culture under a constitutive promoter, is excluded from the nucleus during part of the G1 phase and at the transition from G0 to G1.

Mouse (Murine) GTP Binding Protein Overexpressed in Skeletal Muscle (GEM) interaction partners

  1. Rad, Gem and Rem all reduce depolarization-dependent Ca2+ entry in developing myotubes.

  2. These results suggest that Gem plays an important role in normal beta-cell function by regulation of calcium signalling.

  3. Mechanism of the inhibition of calcium channel activity by Gem.

  4. docking of the RGK protein to the nucleotide-kinase domain of the Cavbeta subunit is reminiscent of the binding of GMP to guanylate kinase

  5. Results identify specific nuclear localization signals (NLS) in Kir/Gem that are both required and sufficient for nuclear transport.

  6. protein expression regulation; calcium channel expression

GEM profil antigène

Antigen Summary

This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16.

Gene names and symbols associated with GEM

  • GTP binding protein overexpressed in skeletal muscle (GEM) anticorps
  • GTP binding protein overexpressed in skeletal muscle (gem) anticorps
  • GTP binding protein overexpressed in skeletal muscle (Gem) anticorps
  • geminin, DNA replication inhibitor (GMNN) anticorps
  • GTP binding protein (gene overexpressed in skeletal muscle) (Gem) anticorps
  • AV020497 anticorps
  • DKFZp470D0612 anticorps
  • Gem anticorps
  • kir anticorps
  • LOC100221129 anticorps
  • xgem anticorps
  • zgc:153003 anticorps

Protein level used designations for GEM

GTP-binding mitogen-induced T-cell protein , GTP-binding protein GEM , GTP-binding protein overexpressed in skeletal muscle , RAS-like protein KIR , kinase-inducible Ras-like protein , GTP binding protein overexpressed in skeletal muscle , Gem GTPase , GTP binding protein gene overexpressed in skeletal muscle , GTP binding protein (gene overexpressed in skeletal muscle) , geminin

2669 Homo sapiens
100173856 Pongo abelii
404771 Gallus gallus
699130 Macaca mulatta
738628 Pan troglodytes
538437 Bos taurus
404772 Sus scrofa
100221129 Taeniopygia guttata
100038040 Xenopus (Silurana) tropicalis
560566 Danio rerio
297902 Rattus norvegicus
51053 Homo sapiens
14579 Mus musculus
611634 Canis lupus familiaris
100716695 Cavia porcellus
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