HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) Kits ELISA

HUWE1 encodes a member of the HECT E3 ubiquitin ligase family. De plus, nous expédions HUWE1 Anticorps (70) et HUWE1 Protéines (2) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
HUWE1 10075 Q7Z6Z7
HUWE1 59026 Q7TMY8
HUWE1 501546  
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Top HUWE1 Kits ELISA sur anticorps-enligne.fr

Showing 8 out of 25 products:

Catalogue No. Reactivité Sensibilité Gamme Images Quantité Fournisseur Livraison Prix Détails
Souris 11 pg/mL 43.75-2800 pg/mL Typical standard curve 96 Tests Connectez-vous pour afficher 15 to 18 Days
$910.56
Détails
Humain 0.067 ng/mL 0.156-10 ng/mL   96 Tests Connectez-vous pour afficher 2 to 3 Days
$713.90
Détails
Rat
  96 Tests Connectez-vous pour afficher 2 to 3 Days
$713.90
Détails
Singe 0.1 ng/mL 1.0-25 ng/mL   96 Tests Connectez-vous pour afficher 15 to 18 Days
$707.14
Détails
Mouton
  96 Tests Connectez-vous pour afficher 15 to 18 Days
$707.14
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Chévre
  96 Tests Connectez-vous pour afficher 15 to 18 Days
$707.14
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Boeuf (Vache)
  96 Tests Connectez-vous pour afficher 15 to 18 Days
$707.14
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Porc
  96 Tests Connectez-vous pour afficher 15 to 18 Days
$707.14
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Plus Kits ELISA pour HUWE1 partenaires d'interaction

Human HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) interaction partners

  1. The data supports an indispensable role for Mule in cardiac homeostasis through the regulation of mitochondrial function via maintenance of Pgc-1alpha (Montrer PPARGC1A Kits ELISA) and Pink1 (Montrer PINK1 Kits ELISA) expression and persistent negative regulation of c-Myc (Montrer MYC Kits ELISA).

  2. these results suggest that HUWE1 protein could contribute to preimplantation embryo development and dysregulated expression of HUWE1 could be related to poor embryo development and miscarriage in IVF clinic.

  3. The authors show that HUWE1 dimerizes in solution and self-associates in cells, and that both occurs through the crystallographic dimer interface. They also demonstrate that HUWE1 is inhibited in cells and that it can be activated by disruption of the dimer interface.

  4. High HUWE1 expression is associated with Ovarian cancer.

  5. It has been shown that mitofusin-2 is modified with K6-linked polyubiquitin in a HUWE1-dependent manner.

  6. HUWE1 is essential for genomic stability, by promoting replication of damaged DNA We show that HUWE1-knockout cells are unable to mitigate replication stress, resulting in replication defects and DNA breakage.

  7. N-myc expression was upregulated in response to stress or following loss of Huwe1, which led to increased proliferation and stem-cell exhaustion.

  8. The interaction with Huwe1 and polyubiquitylation were blocked by disruption of casein kinase 1 (CK1 (Montrer CSNK1A1 Kits ELISA)) activity, and mass spectrometry and mutational analysis identified serine 334 as an important phosphorylation site for Atoh1 (Montrer ATOH1 Kits ELISA) ubiquitylation and subsequent degradation.

  9. Elevated HECTH9 protein expression is associated with pathogenesis of hepatocellular carcinoma.

  10. Mechanistic investigation revealed that HUWE1 can regulate p53 protein level through its stabilization. HUWE1 functions as a tumour suppressor in thyroid cancer progression, which may represent a novel therapeutic target for prevention or intervention of thyroid cancer.

Mouse (Murine) HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) interaction partners

  1. The data supports an indispensable role for Mule in cardiac homeostasis through the regulation of mitochondrial function via maintenance of Pgc-1alpha (Montrer PPARGC1A Kits ELISA) and Pink1 (Montrer PINK1 Kits ELISA) expression and persistent negative regulation of c-Myc (Montrer MYC Kits ELISA).

  2. these results suggest that HUWE1 protein could contribute to preimplantation embryo development and dysregulated expression of HUWE1 could be related to poor embryo development and miscarriage in IVF clinic.

  3. Mule interacts directly with beta-catenin (Montrer CTNNB1 Kits ELISA) and targets it for degradation under conditions of hyperactive Wnt (Montrer WNT2 Kits ELISA) signaling, suggesting that Mule uses various mechanisms to fine-tune the Wnt (Montrer WNT2 Kits ELISA) pathway and provides multiple safeguards against tumorigenesis.

  4. A previously undefined role of Huwe1 in orchestrating the physiological DNA damage response in the male germline that contributes to the establishment and maintenance of spermatogonia.

  5. Taken together, these data identify HUWE1 as a bona fide tumour suppressor gene in the intestinal epithelium and suggest a potential vulnerability of HUWE1-mutated tumours to DNA-damaging agents and inhibitors of anti-apoptotic proteins.

  6. Mule also regulates protein levels of the receptor tyrosine kinase (Montrer ERBB3 Kits ELISA) EphB3 (Montrer EPHB3 Kits ELISA) by targeting it for proteasomal and lysosomal degradation.

  7. this study shows that the E3-ubiquitin ligase Huwe1 (HECT, UBA, and WWE domain-containing 1) is required for proliferating stem cells of the adult mouse hippocampus to return to quiescence.

  8. TNF (Montrer TNF Kits ELISA) activates Mule by inducing the dissociation of Mule from its inhibitor ARF. Inhibition of Mule phosphorylation by silencing Syk (Montrer SYK Kits ELISA) prevents this, thereby inhibiting Mule E3 ligase activity and TNF (Montrer TNF Kits ELISA)-induced JNK (Montrer MAPK8 Kits ELISA) activation and cell death.

  9. expression level of miR-98, which can regulate Caspase-3, was significantly decreased. Huwe1, the host gene of miR-98, was positively associated with miR-98 expression after Silica NP exposure

  10. Thus, modulating the levels of both Huwe1 and USP10 appears to fine-tune the requisite degradation of TBP (Montrer TBP Kits ELISA) during myogenesis.

Cow (Bovine) HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) interaction partners

  1. E3Histone is therefore a HECT domain E3 that likely plays an important role in the chromatin condensation

HUWE1 profil antigène

Antigen Summary

This gene encodes a member of the HECT E3 ubiquitin ligase family. The HECT domain lies in the C-terminus and contains the active-site cysteine which forms an intermediate ubiquitin-thioester bond. E3 family members are divided into three subfamilies based on their protein-protein interaction domains\; this gene encodes a member of the SI(ngle)-HECT E3 subfamily. In lung, breast, and colorectal carcinomas, this gene is highly expressed. Mutations in this gene has been found in 3 unrelated families with X-linked syndromic mental retardation, Turner type.

Gene names and symbols associated with HUWE1

  • HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (HUWE1) anticorps
  • HECT, UBA and WWE domain containing 1 (Huwe1) anticorps
  • HECT, UBA and WWE domain containing 1 (huwe1) anticorps
  • HECT, UBA and WWE domain containing 1 (LOC100123214) anticorps
  • HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (huwe1) anticorps
  • E3 ubiquitin-protein ligase HUWE1 (LOC100380641) anticorps
  • HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (Huwe1) anticorps
  • 5430439H10Rik anticorps
  • arf-bp1 anticorps
  • AU041296 anticorps
  • C80292 anticorps
  • C430014N20Rik anticorps
  • Gm1718 anticorps
  • hecth9 anticorps
  • hspc272 anticorps
  • Huwe1 anticorps
  • ib772 anticorps
  • lasu1 anticorps
  • mule anticorps
  • si:dkey-242a8.2 anticorps
  • URE-B1 anticorps
  • ureb1 anticorps

Protein level used designations for HUWE1

ARF-binding protein 1 , BJ-HCC-24 tumor antigen , E3 ubiquitin-protein ligase HUWE1 , HECT domain protein LASU1 , Mcl-1 ubiquitin ligase E3 , URE-binding protein 1 , homologous to E6AP carboxyl terminus homologous protein 9 , large structure of UREB1 , upstream regulatory element-binding protein 1 , E3Histone , HECT, UBA and WWE domain-containing protein 1 , Mcl-1 ubiquitin ligase , URE-B1 , upstream regulatory element binding protein 1 , HECT, UBA and WWE domain containing 1 , rp3-339a18.4 , e3 ubiquitin-protein ligase HUWE1-like

GENE ID SPECIES
10075 Homo sapiens
59026 Mus musculus
465650 Pan troglodytes
480931 Canis lupus familiaris
511826 Bos taurus
559439 Danio rerio
700136 Macaca mulatta
100060375 Equus caballus
100123214 Nasonia vitripennis
100126217 Xenopus (Silurana) tropicalis
100380641 Salmo salar
100483129 Ailuropoda melanoleuca
100563451 Anolis carolinensis
501546 Rattus norvegicus
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