anti-Insulin-Degrading Enzyme (IDE) Anticorps

IDE encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and k. De plus, nous expédions Insulin-Degrading Enzyme Kits (58) et Insulin-Degrading Enzyme Protéines (15) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
IDE 15925  
IDE 25700 P35559
IDE 3416 P14735
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Top anti-Insulin-Degrading Enzyme Anticorps sur anticorps-enligne.fr

Showing 10 out of 154 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Chèvre Inconjugué IHC, ELISA, WB ABIN334425 (0.1µg/ml) staining of K562 cell lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Connectez-vous pour afficher 6 to 7 Days
$358.02
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-IDE Antibody   Titration: 1.0 ug/ml   Positive Control: Hela Whole Cell IDE is strongly supported by BioGPS gene expression data to be expressed in Human HeLa cells 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Chèvre Biotin ELISA, IHC, WB Biotinylated Antibody (0.3µg/ml) staining of K562 lysate (35µg protein in RIPA buffer), exactly mirroring its parental non-biotinylated product. Primary incubation was 1 hour. Detected by chemiluminescence, using streptavidin-HRP and using NAP blocker as a 100 μg Connectez-vous pour afficher 6 to 7 Days
$358.02
Détails
Humain Lapin Inconjugué IHC (p), WB Western blot analysis of anti-IDE Antibody (Center) (ABIN388241) in A375 cell line lysates (35 µg/lane). IDE (arrow) was detected using the purified polyclonal antibody (1:60 dilution). Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with IDE antibody (Center)(ABIN388241), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Connectez-vous pour afficher 10 to 11 Days
$335.50
Détails
Souris Chèvre Inconjugué ELISA, WB ABIN190754 (1µg/ml) staining of Mouse Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Connectez-vous pour afficher 6 to 7 Days
$358.02
Détails
Humain Chèvre Inconjugué IHC (p), IHC, ELISA, WB ABIN261102(0.1µg/ml) staining of K562 cell lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Western Blot: Insulysin/IDE Antibody [ABIN2611028] - Analysis of IDE antibody using this antibody at 0.1ug/ml in K562 cell lysate. 0.1 mg Connectez-vous pour afficher 7 to 9 Days
$485.88
Détails
Humain Lapin Inconjugué IHC, WB Western blot analysis of extracts of various tissues, using IDE antibody. 100 μL Connectez-vous pour afficher 16 Days
$334.77
Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB Formalin-fixed and paraffin-embedded human gastric carcinoma labeled with Rabbit Anti-IDE Polyclonal Antibody, Unconjugated (ABIN723680) at 1:300 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin-embedded mouse tumor labeled with Rabbit Anti-IDE Polyclonal Antibody, Unconjugated (ABIN723680) at 1:300 followed by conjugation to the secondary antibody and DAB staining 100 μL Connectez-vous pour afficher 3 to 7 Days
$306.90
Détails
Humain Lapin Inconjugué ICC, IHC, WB Figure. Western Blot; Sample: Human HepG2 Cells. 100 μg Connectez-vous pour afficher 13 to 16 Days
$332.00
Détails
Roussette (Chauve-souris) Chèvre Inconjugué IHC, IHC (p) Skeletal muscle, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Prostate, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Connectez-vous pour afficher 11 to 14 Days
$484.00
Détails

anti-Insulin-Degrading Enzyme Anticorps mieux référencés

  1. Human Polyclonal IDE Primary Antibody pour IHC (p), WB - ABIN388241 : Radulescu, Fischer, Stange, Schulze: Promoting scientific standards in Germany. dans Science (New York, N.Y.) 2010 (PubMed)
    Show all 6 Pubmed References

  2. Human Polyclonal IDE Primary Antibody pour IHC (p), IHC - ABIN261102 : Zhao, Xiang, Haroutunian, Buxbaum, Stetka, Pasinetti: Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease. dans Neurobiology of aging 2007 (PubMed)

Plus d’anticorps contre Insulin-Degrading Enzyme partenaires d’interaction

Mouse (Murine) Insulin-Degrading Enzyme (IDE) interaction partners

  1. Our results found that, in the mice with T2D and AD, the activators of PPARg (Montrer PPARG Anticorps)/AMPK (Montrer PRKAA1 Anticorps) signaling pathway significantly increased the expression level of IDE, and decreased the accumulation of Ab40 and Ab42, as well as alleviated the spatial learning and recognition impairments.

  2. elevated IDE expression, in the skeletal muscle, seems to be mediated by activation of AMPK-ACC pathway, in response to exercise

  3. IDE inhibition did notincrease amyloid formation or beta-cell loss.

  4. This study demonstrated that the Decreased IDE and IGF2 expression in the cerebral cortex of pups by early life lead exposure.

  5. Findings show a key role of Pla2g3 (Montrer PLA2G3 Anticorps) on the reduction of IDE, and suggest that cerebrum specific increase of Pla2g3 (Montrer PLA2G3 Anticorps) is involved in the initiation and/or progression of Alzheimer disease.

  6. Abeta (Montrer APP Anticorps) level reduction by CALHM1 (Montrer CALHM1 Anticorps) could be explained by an increase in extracellular Abeta (Montrer APP Anticorps) degradation by insulin-degrading enzyme.

  7. Data suggest that protein restriction down-regulates expression of insulysin (insulin degrading enzyme) in liver and subsequently reduced insulin (Montrer INS Anticorps) clearance.

  8. IDE deficiency in bone marrow-derived cells results in larger atherosclerotic lesions, increased lesion-associated Abeta (Montrer APP Anticorps) and RAGE (Montrer AGER Anticorps), and higher serum cholesterol in male, Ldlr (Montrer LDLR Anticorps)(-/-) mice.

  9. The type 2 diabetes-associated gene ide is required for insulin secretion and suppression of alpha-synuclein levels in beta-cells.

  10. this study identified an upstream promoter element which blocks the reverse transcription of mouse IDE.

Human Insulin-Degrading Enzyme (IDE) interaction partners

  1. These results support the hypothesis that IDE gene expression in different areas of Alzheimer's patient's brains.

  2. People with allelic variation in four genes related to cardiovascular diseases and metabolism were more likely to die: apolipoprotein (APO (Montrer C9orf3 Anticorps))C1 GG and AG carriers, APOE (Montrer APOE Anticorps) varepsilon4 carriers, insulin-degrading enzyme (IDE) TC carriers, and phosphatidylinositol 3-kinase (PI3KCB) GG carriers.

  3. Data suggest the possibility of development of insulin-degrading enzyme (IDE)-based drugs for the treatment of the late-onset form of Alzheimer's disease (AD).

  4. the mechanistic and molecular features of IDE-26S proteasome (Montrer Psmd4 Anticorps) interaction in a cell experimental model, is reported.

  5. No significant associations have been found between other IDE gene single nucleotide polymorphisms of rs4646953, rs2251101 and rs1544210 with Alzheimer disease.

  6. results demonstrate that the polymorphisms rs1887922 and rs1999764 of the IDE gene are associated with late-onset Alzheimer disease susceptibility in the Xinjiang Han population

  7. Cognitive impairment is more frequent among those exposed to the C allele of the rs2209972 SNP of the insulin degrading enzyme gene.

  8. IDE does not play a major role in MHC class I antigen processing, confirming the dominant and almost exclusive role of the proteasome in cytosolic production of MHC class I ligands.

  9. using combinational in silico investigations, study identified that pathogenic nonsynonymous mutations corresponding to p.I54F, p.P122T, p.T533R, p.P581A and p.Y609A have more potential role in structural and functional deviations of IDE activity

  10. Our study provided evidence to IDE, PON1 (Montrer PON1 Anticorps), WFS1 (Montrer WFS1 Anticorps), POU2F1 (Montrer POU2F1 Anticorps), IL1alpha (Montrer IL1A Anticorps) and IL1beta (Montrer IL1B Anticorps) associated with T2D in Pakistanis.

Insulin-Degrading Enzyme (IDE) profil antigène

Profil protéine

This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.

Gene names and symbols associated with IDE

  • insulin degrading enzyme (IDE) anticorps
  • insulin-degrading enzyme (ide) anticorps
  • insulin-degrading enzyme (LOC591315) anticorps
  • insulin-degrading enzyme (CC1G_01115) anticorps
  • insulin-degrading enzyme (Bm1_26615) anticorps
  • insulin-degrading enzyme (PTRG_10875) anticorps
  • metallopeptidase (SJAG_01430) anticorps
  • insulin-degrading enzyme (EBI_21700) anticorps
  • insulin-degrading enzyme (VDBG_06702) anticorps
  • insulin-degrading enzyme (LOAG_08082) anticorps
  • insulin-degrading enzyme (PGTG_04982) anticorps
  • insulin-degrading enzyme (Tsp_00424) anticorps
  • insulin degrading enzyme (Ide) anticorps
  • 1300012G03Rik anticorps
  • 4833415K22Rik anticorps
  • AA675336 anticorps
  • AI507533 anticorps
  • IDE anticorps
  • INSDEGM anticorps
  • INSULYSIN anticorps
  • zgc:162603 anticorps

Protein level used designations for IDE

insulysin , insulin-degrading enzyme , insulin-degrading enzyme-like , insulin protease , insulinase , Abeta-degrading protease

GENE ID SPECIES
450608 Pan troglodytes
561390 Danio rerio
591315 Strongylocentrotus purpuratus
698640 Macaca mulatta
6009544 Coprinopsis cinerea okayama7130
6100223 Brugia malayi
6349187 Pyrenophora tritici-repentis Pt-1C-BFP
7051385 Schizosaccharomyces japonicus yFS275
8641122 Enterocytozoon bieneusi H348
9537184 Verticillium alfalfae VaMs.102
100071303 Equus caballus
100385143 Callithrix jacchus
100434053 Pongo abelii
100482236 Ailuropoda melanoleuca
9945508 Loa loa
10530847 Puccinia graminis f. sp. tritici CRL 75-36-700-3
10901673 Trichinella spiralis
15925 Mus musculus
25700 Rattus norvegicus
3416 Homo sapiens
477768 Canis lupus familiaris
100341888 Oryctolagus cuniculus
100719651 Cavia porcellus
423814 Gallus gallus
100155309 Sus scrofa
523752 Bos taurus
101104194 Ovis aries
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