Kelch-Like 12 (Drosophila) Protéines (KLHL12)

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. De plus, nous expédions KLHL12 Anticorps (85) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
KLHL12 240756 Q8BZM0
KLHL12 59349 Q53G59
KLHL12 266772 Q8R2H4
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Top KLHL12 Protéines sur anticorps-enligne.fr

Showing 4 out of 4 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,797.11
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,797.11
Détails
Wheat germ Humain GST tag 2 μg Connectez-vous pour afficher 11 to 12 Days
$225.40
Détails
Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,630.00
Détails

KLHL12 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine)

Human ,
,
Rat (Rattus)

Plus protéines pour Kelch-Like 12 (Drosophila) (KLHL12) partenaires d'interaction

Mouse (Murine) Kelch-Like 12 (Drosophila) (KLHL12) interaction partners

  1. KLHL12 specifically interacts with the D4 polymorphism, thereby building up a Cul3 (Montrer CUL3 Protéines)-E3 ligase complex with substrate specificity toward the D4 receptor

Human Kelch-Like 12 (Drosophila) (KLHL12) interaction partners

  1. The interaction between the KLHL12 and the C-terminal domain of KHSRP (Montrer KHSRP Protéines) contributed to KHSRP (Montrer KHSRP Protéines) ubiquitination, leading to downregulation of enterovirus internal ribosome entry sites-mediated translation in infected cells.

  2. p44 (Montrer GTF2H2 Protéines)/42 MAPK (Montrer MAPK1 Protéines) phosphorylation, the signaling pathway which is often regulated by beta-arrestins is not influenced by KLHL12, but seems to be exclusively mediated by Galphai protein upon dopamine D4 receptor (Montrer DRD4 Protéines) stimulation.

  3. KLHL12 promotes ubiquitination of the dopamine D4 receptor (Montrer DRD4 Protéines) on non-lysine residues.

  4. molecular cloning and characterization of a novel gene, encoded a human kelch protein containing 568 amino acid residues, termed hDKIR.

  5. KLHL12 specifically interacts with the D4 polymorphism, thereby building up a Cul3 (Montrer CUL3 Protéines)-E3 ligase complex with substrate specificity toward the D4 receptor

Profil protéine KLHL12

Profil protéine

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3 (By similarity).

Gene names and symbols associated with KLHL12

  • Ski2 like RNA helicase (SKIV2L)
  • kelch like family member 12 L homeolog (klhl12.L)
  • kelch like family member 12 (KLHL12)
  • kelch-like family member 12 (klhl12)
  • kelch-like 12 (Klhl12)
  • kelch-like family member 12 (Klhl12)
  • C3IP1 Protéine
  • DKIR Protéine
  • hDKIR Protéine
  • wu:fi60g03 Protéine
  • zgc:92570 Protéine

Protein level used designations for KLHL12

kelch-like 12 (Drosophila) , kelch-like 12 , kelch-like protein 12 , fi60g03 , CUL3-interacting protein 1 , kelch-like protein C3IP1 , DKIR homolog

GENE ID SPECIES
421171 Gallus gallus
431860 Xenopus laevis
457634 Pan troglodytes
479996 Canis lupus familiaris
492362 Danio rerio
240756 Mus musculus
768068 Bos taurus
59349 Homo sapiens
266772 Rattus norvegicus
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