Lysine (K)-Specific Demethylase 5B Protéines (KDM5B)

Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. De plus, nous expédions KDM5B Anticorps (85) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
KDM5B 10765 Q9UGL1
KDM5B 75605 Q80Y84
Rat KDM5B KDM5B 304809  
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Showing 5 out of 6 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
Wheat germ Humain GST tag 10 μg 11 to 12 Days
Insect cells (Sf9) Humain DYKDDDDK Tag JARID1B / KDM5B activity assay. Recombinant JARID1B / KDM5B activity measured using a demethylation assay. MALDI-TOF was used for detection. Recombinant JARID1B / KDM5B enzymatic assay. Demethylase activity of JARID1B / KDM5B was measured with an enzymatic assay. MALDI-TOF was used for detection. Catalytic rate: 20 turnovers/enzyme/hour. 20 μg 1 to 2 Days
Baculovirus infected Insect Cells Souris GST tag   20 μg 1 to 2 Days

KDM5B Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine) , , ,

Plus protéines pour Lysine (K)-Specific Demethylase 5B (KDM5B) partenaires d'interaction

Human Lysine (K)-Specific Demethylase 5B (KDM5B) interaction partners

  1. Findings indicate the importance of cellular phenotypic heterogeneity in therapeutic resistance and identify lysine demethylase 5A/B (KDM5A/B) as key regulators of this process.

  2. This study documents that long-term, moderate hypoxia promotes resistance to the EGFR TKI, gefitinib, in the NSCLC cell line HCC827, which harbors an activating EGFR mutation..Mechanistically, knockdown of LSD1 and PLU-1, prevented and reversed hypoxia-induced gefitinib resistance, suggesting that LSD1 and PLU-1 play key roles in hypoxia-induced gefitinib resistance and epithelial-mesenchymal transition

  3. Results showed that JARID1B was overexpressed in non-small cell lung cancer (NSCLC) cells and its overexpression was associated with tumor size, lymph node metastasis, advanced stages, and poor overall survival in NSCLC patients. JARID1B mediated promotion of EMT and CSCs characteristics in NSCLC cells, suggesting that JARID1B can be a putative marker of tumor progression and poor prognosis in NSCLC patients.

  4. KDM5 inhibition has potential in the treatment of HER2(+) breast cancer.

  5. These results enlighten an important role of a miRNA's circuit in regulating JARID1B's activity and suggest new perspectives for epigenetic therapies.

  6. High JARID1B expression is associated with Osteosarcoma.

  7. In the HCC cell line, Hep3B, KDM5B expression promoted promote tumor cell proliferation and colony formation. Increased expression of KDM5B in HCC tissues, compared with adjacent normal liver tissues, and was associated with larger tumor size, advanced TNM stage, and reduced overall survival in patients with HCC.

  8. Data reinforces the recent observation that the KDM5B haploinsufficiency is not a mechanism involved in intellectual disability and that KDM5B disorder associated with loss of heterozygosity variants is a recessive disorder.

  9. Altered splicing of JARID1B may be important factor increasing melanoma aggressiveness.

  10. both KDM5A and KDM5B are involved in the lengthening of DICER1

  11. HBx activates the histone demethylase KDM5B and induces hepatic progenitor cell-like features in hepatocellular carcinoma

  12. JARID1B directly bound to PI3K/AKT signaling inhibitor SHIP1 gene promoter and decreased SHIP1 gene expression.

  13. We established the function of JARID1B in mediating the cancer stem cell potential of G0-like cells and our results expand understanding of its context-specific roles in malignant and normal stem cell homeostasis

  14. KDM5B is up-regulated in esophageal squamous cell carcinoma cells.MiR-194 targets KDM5B to inhibit esophageal squamous cell carcinoma development and progression.

  15. Study identified USP15 as having recurrent de novo loss of function mutations and discovered evidence supporting two other known genes with recurrent de novo variants (FOXP1 and KDM5B).

  16. research suggests that miR424-5p may act as a novel anti-oncogene in cervical cancer by blocking cell growth through targeting KDM5B-Notch pathway

  17. JARID1B is involved in the pathogenesis of glioma.

  18. PLU-1 was overexpressed in colorectal cancer tissue compared with healthy colon. PLU-1 expression positively correlated with colorectal cancer progression.

  19. Hsa-miR-448 disrupting KDM5B-MALAT1 signalling axis and associated activities in TNBC cells, projects it as a putative therapeutic factor for selective eradication of TNBC cells.

  20. data indicate that parallel immunohistochemical assays of the expression levels of all the isoforms and of the RBP2-H1 variant of JARID1B may be an efficient technique of differentiating between benign naevi and melanomas

Mouse (Murine) Lysine (K)-Specific Demethylase 5B (KDM5B) interaction partners

  1. KDM5B regulates nucleosome positioning in embryonic stem cells.

  2. JARID1B bound to NFkB promoter and affected NFkB expression, resulting in the up-regulation of VEGF-A, promoting proliferation and migration of pulmonary arterial smooth muscle cells in mice with chronic hypoxia-induced pulmonary hypertension.

  3. KDM5B, which demethylates H3K4me3, plays an integral role in regulating RNAPII occupancy, transcriptional initiation and elongation, and alternative splicing events in embryonic stem cells.

  4. data suggest Kdm5b negatively regulates neurogenesis and represses reelin in neural stem cells from the adult subventricular zone.

  5. These results suggest that KDM5B acts to repress type I IFN and other innate cytokines to promote an altered immune response following Respiratory syncytial virus infection that contributes to development of chronic disease.

  6. findings demonstrate that dissociation of the GAPDH/Siah1 pro-apoptotic complex can block high glucose-induced pericyte apoptosis, widely considered a hallmark feature of DR

  7. Deletion of Jarid1b compromises hematopoietic stem cell (HSC) self-renewal capacity; Jarid1b is a positive regulator of HSC potential.

  8. Mechanistically, JARID1B was required for GATA3 recruitment to the Foxa1 promoter to activate Foxa1 expression.

  9. KDM5B is a barrier to the reprogramming process as evidenced by the accelerated reprogramming of differentiated cells in the absence of Kdm5b.

  10. these studies identified Jarid1b as a negative regulator of hematopoietic stem cell (HSC) activity and Jhdmlf as a positive regulator of HSC activity.

  11. Results suggest a role for Jarid1b in Rb-mediated repression of cell cycle genes during senescence.

  12. results delineate an essential role for Jarid1b-mediated transcriptional control during embryonic stem cell differentiation

  13. The present study demonstrated a functional contribution of PLU1 overexpression with concomitant epigenetic dysregulation in cancer progression.

  14. PLU-1/JARID1B/KDM5B is required for embryonic survival and contributes to cell proliferation in the mammary gland and in ER+ breast cancer cells.

  15. Regions upstream of the promoter repress transcription more effectively in a non-malignant breast cell line as compared to breast cancer cell lines.

  16. Ectopic overexpression of mouse Jarid1B, a Yjr119Cp homolog, greatly diminished H3-(lysine) K4me3 and H3-K4me2 in HeLa cells, suggesting these proteins function as K4 demethylases in vivo.

  17. JARID1b blocks differentiation of multiple lineages from ES cells

Cow (Bovine) Lysine (K)-Specific Demethylase 5B (KDM5B) interaction partners

  1. Histone demethylases KDM3A, KDM4A, and KDM4C were expressed before and after embryonic genome activation, whereas KDM5B was mainly expressed during the blastocyst period.

Profil protéine KDM5B

Profil protéine

Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor (By similarity).

Gene names and symbols associated with KDM5B

  • lysine (K)-specific demethylase 5Ba (kdm5ba)
  • lysine (K)-specific demethylase 5Bb (kdm5bb)
  • lysine demethylase 5B (KDM5B)
  • lysine (K)-specific demethylase 5B (Kdm5b)
  • lysine (K)-specific demethylase 5B (KDM5B)
  • lysine demethylase 5B (Kdm5b)
  • 2010009J12Rik Protéine
  • 2210016I17Rik Protéine
  • AW556288 Protéine
  • cb264 Protéine
  • CT31 Protéine
  • D1Ertd202e Protéine
  • id:ibd5050 Protéine
  • Jarid1b Protéine
  • jarid1ba Protéine
  • jarid1bb Protéine
  • mKIAA4034 Protéine
  • PLU-1 Protéine
  • Plu1 Protéine
  • PUT1 Protéine
  • Rb-Bp2 Protéine
  • RBBP2H1A Protéine
  • RGD1565602 Protéine
  • wu:fc44h11 Protéine
  • wu:fd15c05 Protéine
  • zgc:85741 Protéine

Protein level used designations for KDM5B

jumonji, AT rich interactive domain 1B (Rbp2 like) , jumonji, AT rich interactive domain 1Ba (Rbp2 like) , histone demethylase JARID1B-B , jumonji/ARID domain-containing protein 1B-B , lysine-specific demethylase 5B-B , putative DNA/chromatin binding motif , lysine (K)-specific demethylase 5B , Jumonji, AT rich interactive domain 1B (RBP2-like) , jumonji, AT rich interactive domain 1B , lysine-specific demethylase 5B-like , RBP2-H1 , cancer/testis antigen 31 , histone demethylase JARID1B , jumonji/ARID domain-containing protein 1B , lysine-specific demethylase 5B , retinoblastoma-binding protein 2 homolog 1 , retinoblastoma-binding protein 2, homolog 1A , putative DNA/chromatin binding motif 1

327168 Danio rerio
415256 Danio rerio
457630 Pan troglodytes
100011885 Monodelphis domestica
100064707 Equus caballus
100077577 Ornithorhynchus anatinus
100356218 Oryctolagus cuniculus
100483283 Ailuropoda melanoleuca
10765 Homo sapiens
75605 Mus musculus
421168 Gallus gallus
479999 Canis lupus familiaris
100625438 Sus scrofa
540633 Bos taurus
304809 Rattus norvegicus
100723111 Cavia porcellus
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