anti-Mannosidase, Alpha, Class 1B, Member 1 (MAN1B1) Anticorps

MAN1B1 encodes an enzyme belonging to the glycosyl hydrolase 47 family. De plus, nous expédions MAN1B1 Protéines (9) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
MAN1B1 11253 Q9UKM7
MAN1B1 227619 A2AJ15
MAN1B1 499751 B2GUY0
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Top anti-MAN1B1 Anticorps sur

Showing 10 out of 20 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded SCC25 xenograft, using MAN1B1, antibody at 1:100 dilution. IHC-P Image MAN1B1 antibody [C1C3] detects MAN1B1 protein at cytoplasm on mouse kidney by immunohistochemical analysis. Sample: Paraffin-embedded mouse kidney. MAN1B1 antibody [C1C3] , diluted at 1:500. 100 μL Connectez-vous pour afficher 3 to 4 Days
Humain Souris Inconjugué ELISA, WB 100 μg Connectez-vous pour afficher 11 to 14 Days
Humain Lapin Inconjugué ELISA, WB 100 μL Connectez-vous pour afficher Disponible
Humain Lapin Inconjugué ELISA, ICC, IF, WB Western blot analysis on 3T3 cell lysate using MAN1B1 Antibody,The lane on the left is treated with the antigen-specific peptide. ABIN6266758 staining NIH-3T3 cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibody. 100 μL Connectez-vous pour afficher 11 to 12 Days
Humain Souris Inconjugué IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to MAN1B1 on formalin-fixed paraffin-embedded human stomach. [antibody concentration 3 ug/ml] MAN1B1 monoclonal antibody (M01), clone 6B1 Western Blot analysis of MAN1B1 expression in A-431 . 100 μg Connectez-vous pour afficher 11 to 12 Days
Humain Lapin Inconjugué IHC, IHC (p), WB   100 μL Connectez-vous pour afficher 11 to 14 Days
Humain Lapin Inconjugué IHC (fp), WB   100 μL Connectez-vous pour afficher 6 to 8 Days
Humain Lapin Inconjugué ELISA, WB   200 μL Connectez-vous pour afficher 12 to 14 Days
Humain Lapin Inconjugué WB Western blot analysis of extracts of various cell lines, using MAN1B1 antibody (ABIN6291169) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s. 50 μL Connectez-vous pour afficher 11 to 13 Days
Humain Lapin Inconjugué IHC, WB   100 μL Connectez-vous pour afficher 2 to 3 Days

Plus d’anticorps contre MAN1B1 partenaires d’interaction

Human Mannosidase, Alpha, Class 1B, Member 1 (MAN1B1) interaction partners

  1. Novel MAN1B1 variants were identified in patients with facial dysmorphism, hypotonia, truncal obesity and in some, behavioural problems.

  2. Results show that MAN1B1 expression was higher in bladder cancer (BC) tissues than those in normal tissues. Its overexpression was associated with poor prognosis. Furthermore, MAN1B1 seems to act as an oncogene in BC, which improved the likelihood of MAN1B1 taking on a promising prognostic biomarker.

  3. The two genetic associations with severe liver disease that had been suspected previously (one SNP for SERPINA1 and another for MAN1B1) were not confirmed in our cohort. For MAN1B1, four major haplotypes were identified but the prevalence of PHT did not significantly differ between them.

  4. in the bound substrate complex, hydrophobic stacking interactions between Trp residues and the glycan core anchor the base of the glycan structure to the enzyme cleft

  5. MAN1B1 defective congenital disorder of glycosylation is reviewed.

  6. Data show that HIV-1 env protein interacts with alpha-mannosidases ERManI (MAN1B1) and initiates endoplasmic reticulum (ER)-associated protein degradation (ERAD) pathway degradation process.

  7. Results suggest that endoplasmic reticulum mannosidase I (ERManI) is turned over by an active autophagic process.

  8. The properties of ERMAN1 enable rapid selection of endoplasmic reticulum-associated degradation substrates in the endoplasmic reticulum.ERMAN1 digests mono-, di- and tri-glucosylated N-glycans.

  9. we linked mutations in MAN1B1 to a Golgi glycosylation disorder. Additionally, our results support the recent findings on MAN1B1 localization

  10. MAN1B1 deficiency appeared to be a frequent cause in our cohort of patients with unsolved congenital disorder of glycosylation type II.

  11. A novel post-transcriptional regulatory mechanism for ERManI via miR-125b and this molecule contributes to the regulation of carcinogenesis in hepatocellular carcinoma.

  12. ERManI and gamma-COP contribute to a golgi-based quality control module that facilitates the retrieval of captured ERAD substrates back to the endoplasmic reticulum.

  13. Golgi localization of ERManI defines spatial separation of the mammalian glycoprotein quality control system

  14. A homozygous nonsense mutation in MAN1B1 segregated with nonsyndromic autosomal-recessive intellectual disability and additional dysmorphic features.

  15. ER processing alpha1,2-mannosidase (ER ManI) has a role in ER-associated degradation of misfolded proteins

  16. Modification by endoplasmic reticulum mannosidase I (ERManI) contributes to the preferential selection of the misfolded AAT monomer for proteasomal degradation.

  17. glycoside bond cleavage proceeds through a least motion conformational twist of a properly predisposed substrate

  18. Increased activity of alpha-mannosidase in the peritoneal fluid is associated with gynecologic cancers and pelvic inflammatory disease

  19. overexpression of Golgi alpha1,2-mannosidase IA, IB, and IC also accelerates ERAD of terminally misfolded human alpha1-antitrypsin variant null (Hong Kong) (NHK), and mannose trimming from the N-glycans on NHK in 293 cells

  20. ERManI is required for trimming to Man(5-6)GlcNAc(2) and for endoplasmic reticulum associated degradation in cells in vivo.

MAN1B1 profil antigène

Profil protéine

This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11.

Gene names and symbols associated with MAN1B1

  • mannosidase alpha class 1B member 1 (MAN1B1) anticorps
  • mannosidase, alpha, class 1B, member 1 L homeolog (man1b1.L) anticorps
  • endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (LOC480667) anticorps
  • mannosidase, alpha, class 1B, member 1 (man1b1) anticorps
  • mannosidase, alpha, class 1B, member 1 (Man1b1) anticorps
  • E430019H13Rik anticorps
  • ERMan1 anticorps
  • Gm108 anticorps
  • MAN1B1 anticorps
  • MANA-ER anticorps
  • MRT15 anticorps
  • RGD1563595 anticorps

Protein level used designations for MAN1B1

mannosidase, alpha, class 1B, member 1 , alpha 1,2-mannosidase , ER alpha 1,2-mannosidase , Man9GlcNAc2-specific processing alpha-mannosidase , endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase , endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 1 , ER alpha-1,2-mannosidase , ER mannosidase 1 , man9GlcNAc2-specific-processing alpha-mannosidase

417296 Gallus gallus
447291 Xenopus laevis
473099 Pan troglodytes
480667 Canis lupus familiaris
100145194 Xenopus (Silurana) tropicalis
11253 Homo sapiens
227619 Mus musculus
499751 Rattus norvegicus
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