Matrix Metalloproteinase 20 Protéines (MMP20)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. De plus, nous expédions MMP20 Anticorps (86) et MMP20 Kits (11) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MMP20 9313 O60882
MMP20 30800 P57748
Rat MMP20 MMP20 300341  
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Top MMP20 Protéines sur anticorps-enligne.fr

Showing 7 out of 7 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,227.64
Détails
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,227.64
Détails
Escherichia coli (E. coli) Humain His tag Validation with Western Blot 50 μg 11 Days
$302.50
Détails
Levure Sanglier His tag   1 mg 60 to 71 Days
$3,032.33
Détails
Levure Boeuf (Vache) His tag   1 mg 60 to 71 Days
$3,032.33
Détails
Escherichia coli (E. coli) Souris T7 tag,His tag 100 μg 15 to 18 Days
$736.00
Détails
Escherichia coli (E. coli) Humain Inconjugué   100 μg 7 to 9 Days
$871.20
Détails

MMP20 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human

Mouse (Murine)
,

Plus protéines pour Matrix Metalloproteinase 20 (MMP20) partenaires d'interaction

Human Matrix Metalloproteinase 20 (MMP20) interaction partners

  1. the minimum alleles of rs10895322, rs1784424, rs3781788, and rs1573954 correlated with an increased risk of alcohol-induced ONFH (P<0.05). Genetic model analysis revealed significant associations of 9 SNPs with alcohol-induced ONFH occurrence after adjustment for age (P<0.05): 2 protective SNPs (rs1711423 and rs1784418) and 7 high-risk SNPs (rs10895322, rs1784424, rs3781788, rs7126560, rs1573954, rs1711399, rs2292730).

  2. The polymorphisms in MMP2, MMP9 and MMP20 genes were not statistically associated with human dental fluorosis.

  3. The levels of MMP20 silencing-induced downregulation differed amongst CSC markers, with ABCG2 and CD44 showing more pronounced downregulations.

  4. common variants at 11q22.2 within MMP20 associate with neuroblastoma cases harboring 11q deletion (rs10895322)

  5. The article data showed that MMP20 rs1784418 C>T (Matrix metalloproteinase 20) appears to protect against dental caries, but its effects are likely to be more marked in certain populations.

  6. DSPP-MMP20 pair may play a role in the normal turnover of cell surface proteins and/or repair of pericellular matrix proteins of the basement membranes in the metabolically active duct epithelial system of the nephrons.

  7. Levels of matrix metalloproteinases MMP-19 and MMP-20 expression are significantly increased in pancreatic ductal adenocarcinoma (PDAC).

  8. The expression of MMP20 was lower in calcifying cystic odontogenic tumor when compared to all tumors and cysts.

  9. The growth of choroidal neovascularization in AMD would be affected by 2 genes: MMP20, a newly confirmed gene expressed in the retina, and ARMS2/HTRA1, a well-known susceptibility gene for AMD.

  10. Novel homozygous mutation MMP20 (c.1054G>A, p.Glu352Lys) genes were identified in amelogenesis imperfect consanguinity. Mutant MMP20 was expressed at a normal level but secreted only minimally with proteolytic function.

  11. expression of MMP-20 and co-expression and potential interaction with DSPP in human major salivary gland tissues

  12. The results identify MMP-20 as a broad activator of pro-KLKs, suggesting the potential for intersection of the KLK and MMP axes under pathological dysregulation of MMP-20 expression.

  13. Polymorphisms of MMP7 and MMP20 genes may be surrogate markers to predict long-term outcomes after kidney transplantation.

  14. mineralized content slightly decreased; magnesium substituting for calcium in crystal. anomalies affected enamel with minimal interrod enamel; apatite crystals perpendicular to enamel prisms, suggesting possible new role for MMP20 in enamel formation.

  15. amelogenesis imperfecta-causing mutations were identified in three of the probands: 2)a novel missense transition mutation in both MMP20 alleles (g.15390A>G; c.611A>G; p.His204Arg) that substituted arginine for histidine.

  16. Variation in MMP20 may be associated with caries experience mainly in Caucasian subjects with poor oral health habits.

  17. hypocalcified amelogenesis imperfecta, Witkop type III, was unrelated to previously described mutations in the ENAM or MMP-20 genes

  18. MMP-20 is overexpresssed in LSCC compared with the adjacent normal laryngeal epithelium.

  19. Associations between tooth agenesis and MMP1 (p=0.007), and MMP20 (p=0.03) were found in Brazilian families. MMP20 continued to be associated with tooth agenesis (p=0.01). Mmp20 was not expressed during the initial stages of tooth development.

  20. Enamelysin and collagen XVIII were co-localized in the developing enamel matrix and stratum intermedium and in the enamel-like tumor matrix of odontogenic tumors.

Xenopus laevis Matrix Metalloproteinase 20 (MMP20) interaction partners

  1. MMP20 in a common ancestor of tetrapods might have been recruited for the processing of AMEL and conserved over 350 million years of evolution.

Pig (Porcine) Matrix Metalloproteinase 20 (MMP20) interaction partners

  1. MMP-20 is the enzyme that processes ameloblastin during the secretory stage of amelogenesis

  2. MMP-20 processes dental sialophosphoprotein into smaller subunits in the dentin matrix during odontogenesis

Mouse (Murine) Matrix Metalloproteinase 20 (MMP20) interaction partners

  1. polymorphisms in Ambn, Col14a1, and Mmp20 are associated with the susceptibility to dental fluorosis

  2. increased cadherin cleavage by transgenic MMP20 in the wild type background releases excess beta-catenin, which translocates to ameloblast nuclei to promote cell migration/invasion. Therefore, MMP20 plays a role in normal ameloblast migration through tightly controlled Wnt signaling and MMP20 overexpression disrupts this process.

  3. MMP-20 action guides the growth morphology of the forming hydroxyapatite crystals and enhances their crystallinity.

  4. Matrix metalloproteinase-20 over-expression is detrimental to enamel development

  5. MMP20 cleaves extracellular domains of cadherin adherens junction proteins, both E- and N-cadherin transcripts are expressed at significantly higher levels in Mmp20 null mice; in Mmp20 ablated mice N-cadherin expression persists during maturation stage

  6. enamel of M180Tg/AmelxKO mice was thinner than WT, it had similar mechanical properties and decussating enamel prisms, which were abolished by the loss of MMP20 in the M180Tg/DKO mice.

  7. required for ameloblast cell movement necessary to form the decussating enamel rod patterns, for the prevention of ectopic mineral formation, and to maintain a functional dentin-enamel junction

  8. MMP20 may influence ameloblast developmental progression through hydrolysis of cadherin extracellular domains with associated release of transcription factor(s).

  9. Effect of kallikrein 4 loss on enamel mineralization: comparison with mice lacking matrix metalloproteinase 20.

  10. Runx2 regulates the expression of ODAM and nuclear ODAM serves an important regulatory function in the mineralization of enamel through the regulation of MMP-20 apart from a different, currently unidentified, function of extracellular ODAM.

  11. expression of MMP-20 correlates with the stage-associated changes in the digestion of enamel proteins

  12. enamelysin activity is essential for proper enamel development in mice

  13. Enamelysin and collagen XVIII were co-localized in the developing enamel matrix and stratum intermedium and in the enamel-like tumor matrix of odontogenic tumors.

  14. Analyses of amelogenin mRNA between control and Mmp20(-/-)mice revealed no differences in the splicing pattern.

  15. The secretory-stage enamel organic extracellular matrix of Mmp20-/- mice showed a significant decrease in optical retardation as compared with Mmp20+/+ and Mmp20+/- mice (p=0.0000).

  16. Mice lacking expression of the AmelX, Enam and Mmp20 genes have been generated.

Profil protéine MMP20

Profil protéine

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3.

Gene names and symbols associated with MMP20

  • matrix metallopeptidase 20 (MMP20)
  • matrix metallopeptidase 20 L homeolog (mmp20.L)
  • matrix metallopeptidase 20 (enamelysin) (Mmp20)
  • matrix metallopeptidase 20 (Mmp20)
  • AI2A2 Protéine
  • MMP-20 Protéine
  • mmp20 Protéine
  • MMP25 Protéine

Protein level used designations for MMP20

enamel metalloproteinase , matrix metalloproteinase 20 (enamelysin) , matrix metalloproteinase-20 , MMP-20 , enamelysin , matrix metallopeptidase 20 (enamelysin) , matrix metallopeptidase 25 , matrix metallopeptidase 20 , matrix metalloproteinase 20 , matrix metalloproteinase

GENE ID SPECIES
9313 Homo sapiens
281916 Bos taurus
740407 Pan troglodytes
100049153 Xenopus laevis
100355428 Oryctolagus cuniculus
396939 Sus scrofa
30800 Mus musculus
300341 Rattus norvegicus
611829 Canis lupus familiaris
100061314 Equus caballus
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