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The protein encoded by MATK has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack. De plus, nous expédions Megakaryocyte-Associated tyrosine Kinase Anticorps (118) et Megakaryocyte-Associated tyrosine Kinase Protéines (11) et beaucoup plus de produits pour cette protéine.
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After IGF-I stimulation, CTK is recruited to IGF-IR and its recruitment facilitates CTK's subsequent association with phospho-SHPS-1.
ERBB2 binds to the SH2 domain of CHK and inhibits cell growth in human breast tumor cell lines
Overexpression of the Csk homologous kinase facilitates phosphorylation of akt/protein kinase b in breast neoplasms
CHK Leu223 stabilizes the movement of the alphaC-helix of the protein tyrosine kinase
Loss of CHK expression is associated with human brain tumors
Nuclear multi-lobulation in late S phase, which is dependent on polymerization and depolymerization of microtubules, may be involved in nuclear Chk-induced inhibition of proliferation.
striking functional differences between the Csk and Chk SH2 domains and revealed functional similarities between the Chk and Src SH2 domains
This study describes for the first time the Src-independent actions of CHK and provides novel insights into CHK function in neural cells.
Matk/CHK is not functionally redundant with Csk, and this tyrosine kinase plays an important role as a regulator of immunologic responses
Findings indicate that the importance of the N-terminal domain to Chk-induced tyrosine phosphorylation in the nucleus, and implicate that nuclear tyrosine-phosphorylated proteins may contribute to inhibition of cell proliferation.
Progesterone increases MATK in mast cells and reducs cell proliferation.
These results reveal a potentially important role for CHK in Src activation and tumorigenicity in colon cancer cells.
CHK is capable of inhibiting the CXCL12-CXCR4 pathway in neuroblastoma.
The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene.
megakaryocyte-associated tyrosine kinase
, megakaryocyte-associated tyrosine-protein kinase-like
, CSK homologous kinase
, Csk-homologous kinase
, Csk-type protein tyrosine kinase
, HYL tyrosine kinase
, hematopoietic consensus tyrosine-lacking kinase
, hydroxyaryl-protein kinase
, leukocyte carboxyl-terminal src kinase related
, megakaryocyte-associated tyrosine-protein kinase
, protein kinase HYL
, tyrosine kinase MATK
, tyrosine-protein kinase CTK
, tyrosylprotein kinase
, Csk homologous kinase
, protein kinase NTK
, megakaryocyte-associated tyrosine kinase (non-receptor protein tyrosine kinase)
, non-receptor protein kinase protein
, protein kinase BATK
, carboxyl-terminal SRC kinase homologous kinase