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MARCH6 encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. De plus, nous expédions MARCH6 Protéines (5) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 64 products:
Human Polyclonal MARCH6 Primary Antibody pour ELISA - ABIN449561 : Kreft, Wang, Hochstrasser: Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI). dans The Journal of biological chemistry 2006 (PubMed)
cholesterol reduced the levels of at least three known MARCH6 substrates, indicating that cholesterol-mediated MARCH6 stabilization increases its activity.
TRC8 and MARCH6 depletion altered the turnover of the tail-anchored protein heme oxygenase-1.
mutant NPC1 degradation is regulated by selective endoplasmic reticulum autophagy and MARCH6-dependent endoplasmic-reticulum-associated degradation
Data suggest that human MARCH6 and Saccharomyces cerevisiae Doa10 ubiquitin ligases are functionally similar.
Loss of MARCH6 increases expression of SREBP-regulated genes involved in cholesterol biosynthesis and lipoprotein uptake.
Data suggest that unsaturated fatty acids (oleate; oleoyl-CoA) stabilize SM/SQLE (squalene monooxygenase; catalyzes 1st oxygenation step in cholesterol synthesis) most likely via inhibition of poly-ubiquitination by MARCH6.
MARCH6 and squalene monooxygenase (SM) physically interact, and consistent with MARCH6 acting as an E3 ligase, its overexpression reduces SM abundance in a RING-dependent manner.
analysis of yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4
TEB4 interacts with and mediates loss of type 2 iodothyronine deiodinase (D2)activity, indicating that D2 ubiquitination and degradation can be tissue specific, depending on WSB-1 and TEB4 expression levels.
This gene encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
E3 ubiquitin-protein ligase MARCH6 , RING finger protein 176 , doa10 homolog , membrane-associated RING finger protein 6 , membrane-associated RING-CH finger protein 6 , membrane-associated RING-CH protein VI , MARCH-VI , membrane-associated ring finger (C3HC4) 6 , fa98a02 , E3 ubiquitin-protein ligase MARCH6-like , e3 ubiquitin-protein ligase MARCH6-like