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MARCH9 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 22.214.171.124). De plus, nous expédions Membrane-Associated Ring Finger (C3HC4) 9 Protéines (4) et beaucoup plus de produits pour cette protéine.
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Overexpression of MARCH9 was found to attenuate the oncogenic effect of ICAM-1, suggesting that MARCH9 may inhibit tumor progression by downregulating ICAM-1 signaling.
this study shows that MARCH9-mediated ubiquitination regulates MHC I export from the trans Golgi network
Downregulation of Mult1 by MARCH9 was reversed by heat-shock treatment, which resulted in the dissociation of the two proteins and increased the amount of Mult1 at the cell surface.
MARCH-IX expression causes ubiquitination and downregulation of ICAM-1
MARCH9 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 126.96.36.199). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH9 induces internalization of several membrane glycoproteins and directs them to the endosomal compartment (Bartee et al., 2004
membrane-associated ring finger 9
, membrane-associated RING-CH protein IX
, membrane-associated ring finger (C3HC4) 9
, E3 ubiquitin-protein ligase MARCH9
, e3 ubiquitin-protein ligase MARCH9
, RING finger protein 179
, membrane-associated RING finger protein 9