Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms.
Gene names and symbols associated with MRPL4
mitochondrial ribosomal protein L4 (MRPL4) anticorps
mitochondrial ribosomal protein L4 (Mrpl4) anticorps
mitochondrial ribosomal protein L4 (mrpl4) anticorps
Protein level used designations for MRPL4
39S ribosomal protein L4, mitochondrial