Mix Paired-Like Homeobox Protéines (MIXL1)

Homeodomain proteins, such as MIXL1, are transcription factors that regulate cell fate during development (Hart et al., 2005 [PubMed 15982639]).[supplied by OMIM, Mar 2008].. De plus, nous expédions MIXL1 Anticorps (54) et MIXL1 Kits (3) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MIXL1 83881 Q9H2W2
Rat MIXL1 MIXL1 289311  
MIXL1 27217 Q9WUI0
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Showing 5 out of 5 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Détails
Wheat germ Humain GST tag 10 μg 11 to 12 Days
$414.29
Détails
Levure Poulet His tag   1 mg 60 to 71 Days
$2,517.17
Détails
Levure Xenopus laevis His tag   1 mg 60 to 71 Days
$3,036.00
Détails

MIXL1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour Mix Paired-Like Homeobox (MIXL1) partenaires d'interaction

Human Mix Paired-Like Homeobox (MIXL1) interaction partners

  1. Findings support the existence of a novel MIXL1-c REL mediated survival axis in AML that can be targeted by BMPR1 inhibitors. (MIXL1- human gene, Mixl1- mouse ortholog, MIXL1- protein).

  2. results demonstrate that Mixl1 and Flk1 play roles...during dimethyl sulfoxide-induced mesodermal specification in P19 cells.

  3. Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity

  4. shows functional similarity to Xenopus Mix.1

  5. These results demonstrate for a functional role for TGF-beta ligands in regulation of mammalian Mixl1, identify FoxH1 as an essential co-activator, and implicate Nodal as the embryonic regulator of Mixl1 in mesendoderm morphogenesis.

  6. MIXL1 protein is differentially expressed in non-Hodgkin lymphoma and Hodgkin lymphoma; findings suggest that MIXL1 overexpression may play a role in driving proliferatin or blocking differentiation in lymphoma oncogenesis

  7. Targeted insertion in human embryonic stem cells of sequences encoding green fluorescent protein (GFP) into the locus of MIXL1, a gene transiently expressed in the primitive streak during embryogenesis.

Mouse (Murine) Mix Paired-Like Homeobox (MIXL1) interaction partners

  1. In this study, we demonstrated that forced expression of Mix-like protein 1 (encoded by Mixl1) can be used to guide contribution of mouse embryonic stem cells to endodermal organs after blastocyst injection.

  2. Embryonic localization of Mixl1 shows its co-localized with the early hematopoietic marker, Runx1, in the allantois and visceral yolk sac blood islands.

  3. At later stages, in contrast with wild-type embryos, E7.5-8.0, Mixl1 knockout (KO) KO/KO embryos lacked morphologically recognizable midline structures such as the node and notochord.

  4. Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity

  5. These data support the hypothesis that Mixl1 directly regulates Pdgfralpha and Flk1 gene expression.

  6. results strongly suggest that Gsc is a direct target gene of Mixl1 during embryogenesis.

  7. required for the morphogenesis of axial mesoderm, the heart and the gut during embryogenesis

  8. non-cell autonomous role in nascent mesoderm in the formation and/or patterning of adjacent definitive endoderm.

  9. Mixl1 is required for efficient haematopoiesis and BMP4-induced ventral mesoderm patterning in differentiating ES cells

  10. all mice reconstituted with Mixl1-transduced bone marrow developed fatal, transplantable acute myeloid leukemia with a mean latency period of 200 days

  11. As goosecoid is itself induced in a Foxh1-dependent manner, we propose that Foxh1 initiates positive and negative transcriptional circuits to refine cell fate decisions during gastrulation

  12. Overexpression of Mixl1 appears capable of inducing an abnormal self-renewal capacity in granulocytic precursors

  13. The studies suggest that high levels of Mixl1 preferentially allocate cells to the endoderm during ESC differentiation.

Profil protéine MIXL1

Profil protéine

Homeodomain proteins, such as MIXL1, are transcription factors that regulate cell fate during development (Hart et al., 2005

Gene names and symbols associated with MIXL1

  • Mix paired-like homeobox (MIXL1)
  • Mix paired-like homeobox 1 (Mixl1)
  • Mix1 homeobox-like 1 (Xenopus laevis) (Mixl1)
  • CMIX Protéine
  • MILD1 Protéine
  • MIX Protéine
  • MIXL Protéine
  • MIXL1 Protéine
  • Mm1 Protéine
  • Mml Protéine

Protein level used designations for MIXL1

Mix1 homeobox-like 1 (Xenopus laevis) , Mix-like homeobox protein 1 , MIX1 homeobox-like protein 1 , hMix , homeobox protein MIXL1 , homeodomain protein MIX , mix.1 homeobox-like protein , CMIX homeobox , Mix1 homeobox-like 1 , mMix

GENE ID SPECIES
737620 Pan troglodytes
100347077 Oryctolagus cuniculus
83881 Homo sapiens
395838 Gallus gallus
614854 Bos taurus
289311 Rattus norvegicus
27217 Mus musculus
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