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CDHR5 is a novel mucin-like gene that is a member of the cadherin superfamily. De plus, nous expédions CDHR5 Anticorps (64) et CDHR5 Kits (6) et beaucoup plus de produits pour cette protéine.
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Expression of MUCDHL is negatively regulated by the activation of the beta-catenin signaling pathway in normal and cancer colorectal enterocytes.
It suggests that methylation status of MUPCDH promoter can be used as a novel epigenetic biomarker and a therapeutic target in ADPKD.
Study found that brush border assembly is driven by the formation of Ca(2+)-dependent adhesion links between adjacent microvilli. Intermicrovillar links are composed of protocadherin-24 and mucin-like protocadherin, which target to microvillar tips and interact to form a trans-heterophilic complex.
The transcription factor Cdx2 activates expression of the protocadherin Mucdhl, which interacts with beta-catenin and regulates activities of colon cancer cells.
The MUPCDH genetic polymorphism rs3758650 was considered a genetic marker to predict symptomatic Gallstone disease subjects.
Our data consequently suggest that down-regulation of mu-protocadherin expression is a common event in colorectal carcinogenesis and might therefore play an important role in this pathologic process.
identifed the human mu-protocadherin ortholog and examined its expression in the developing kidney
MUCDHL genes are biallelically expressed in multiple fetal and adult tissues both in humans and in mice
This gene is a novel mucin-like gene that is a member of the cadherin superfamily. While encoding nonpolymorphic tandem repeats rich in proline, serine and threonine similar to mucin proteins, the gene also contains sequence encoding calcium-binding motifs found in all cadherins. The role of the hybrid extracellular region and the specific function of this protein have not yet been determined. Alternatively spliced transcript variants encoding different isoforms have been described.
, mucin and cadherin-like protein
, mucin and cadherin like
, mucin-like protocadherin