N-Acetyltransferase 1 (Arylamine N-Acetyltransferase) Protéines (NAT1)

NAT1 is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. De plus, nous expédions NAT1 Anticorps (97) et NAT1 Kits (10) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
NAT1 9 P18440
NAT1 17960 P50294
NAT1 116631 P50297
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Top NAT1 Protéines sur anticorps-enligne.fr

Showing 10 out of 16 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
Escherichia coli (E. coli) Humain His tag Validation with Western Blot 50 μg Connectez-vous pour afficher 11 Days
Escherichia coli (E. coli) Humain His tag 50 μg Connectez-vous pour afficher 15 to 19 Days
Levure Cat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
Levure Hamsters dorés syriens His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
Levure Boeuf (Vache) His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
Levure Lapin His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days

NAT1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
Mouse (Murine)
Rat (Rattus)

NAT1 Protéines mieux référencés

  1. Human NAT1 Protein expressed in Wheat germ - ABIN1311997 : Millner, Doll, Cai, States, Hein: Phenotype of the most common "slow acetylator" arylamine N-acetyltransferase 1 genetic variant (NAT1*14B) is substrate-dependent. dans Drug metabolism and disposition: the biological fate of chemicals 2011 (PubMed)
    Show all 2 Pubmed References

Plus protéines pour N-Acetyltransferase 1 (Arylamine N-Acetyltransferase) (NAT1) partenaires d'interaction

Human N-Acetyltransferase 1 (Arylamine N-Acetyltransferase) (NAT1) interaction partners

  1. we have observed that differences in NAT1 activity, particularly the knockout of NAT1, significantly alters the bioenergetics profile of MDA-MB-231 triple negative breast cancer cells.

  2. multiple populations in breast cancer can be segregated based on NAT1 mRNA levels; for patients with low expression, overall survival is significantly less than for patients with intermediate or high expression; low NAT1 expression shows a distinct poor response to chemotherapy

  3. Results indicate that haplotypes that provide rapid N-acetyltransferase 1 (NAT1) and slow N-acetyltransferase 2 (NAT2) acetylating phenotypes may influence the development of acute lymphoblastic leukemia (ALL) in children.

  4. NAT1-catalyzed N-acetylation in peripheral blood mononuclear cells is higher in T cell than in other immune cell subtypes and that individual variation in N-acetylation capacity is dependent upon NATb mRNA and NAT1 haplotype.

  5. Data showed that NAT1, NAT2, and ESR1 expression were increased in primary breast tumor tissue and that NAT1 expression was much higher than NAT2. NAT1 and ESR1 expression were strongly associated, whereas NAT2 and ESR1 expression were not. Although NAT1 and NAT2 expression were associated, the magnitude was moderate.

  6. the results suggested that there was no association between NAT1*10 allele and bladder cancer risk (meta-analysis).

  7. identified a novel endogenous role for human NAT1 that might explain some of its effects in cancer cell growth and survival

  8. N-acetyltransferase polymorphisms are associated with risk of lymphoma subtypes.

  9. The association of colorectal adenomas with the rs6983267 variant at 8q24 was considered as 'highly credible', the 'less credible' associations were identified with a further four variants of four independent genes: MTHFR c.677C>T p.A222V(rs1801133), TP53 c.215C>G p.R72P (rs1042522), NQO1 c.559C>T p.P187S (rs1800566), and NAT1 alleles imputed as fast acetylator genotypes. [meta-analysis]

  10. The rs1799931(G>A) genotype was detected in the control population but not in the T2DM population. The wild type (G) allele frequency was higher in T2DM than controls. The mutant allele (A) in rs1799931(G>A) had a protective effect for T2DM.

  11. NAT1 genotype affects thioguanine nucleotide levels in patients treated with thiopurines and aminosalicylates and could therefore influence the toxicity and efficacy of these drugs.

  12. NAT1 genetic polymorphisms were found to be a risk factor for smokers in the Black population of South Africa with esophageal squamous cell carcinoma.

  13. NAT1 has a role in the metabolic pathway of nicotine/cotinine and/or their metabolites.

  14. We report that miR-1290 directly targets the NAT1 3'-UTR and that NAT1 protein expression is correlated with improved OS of breast cancer patients.

  15. Arylamine N-acetyltransferase polymorphisms in Han Chinese patients with ankylosing spondylitis and their correlation to the adverse drug reactions to sulfasalazine

  16. Candidate gene NAT1 were elevated in male breast cancer biopsies compared to those from female patients without regard to Estrogen Receptors status.

  17. Data suggest that NAT1/NAT2 participate in biotransformation of many aromatic/heterocyclic amines; molecular models have been developed regarding acetylation mechanism, active site structure, and substrate/inhibitor-binding specificity. [REVIEW]

  18. Epidemiological studies suggest that the NAT1 and NAT2 acetylation polymorphisms modify the risk of developing cancers of the urinary bladder, colorectal, breast, head and neck, and lung

  19. the present study provides evidence for the role of NAT1 and NAT2 variations in NSCLP, and indicates that interactions between the NAT1 and NAT2 genes may be important in susceptibility to NSCLP.

  20. NAT1 rapid acetylation alone as well as combination of NAT1 rapid-NAT2 slow acetylation did not modulate the risk of oral precancer and cancer in an Indian patient population.

Mouse (Murine) N-Acetyltransferase 1 (Arylamine N-Acetyltransferase) (NAT1) interaction partners

  1. these studies demonstrate that Nat1 deletion promotes reduced mitochondrial activity and is associated with ectopic lipid-induced insulin resistance. These results provide a potential genetic link among mitochondrial dysfunction with increased ectopic lipid deposition, insulin resistance, and type 2 diabetes.

  2. Ca(2+)-dependent N-acyltransferase absolutely required Calcium for its activity and the activity was enhanced by phosphatidylserine.

  3. Nat1 is involved in the translation of proteins that are required for cell differentiation.

  4. This study illustrated that deficiency of NAT1/2 decreases isoniazid (INH) acetylation, but increases the interactions of INH with endobiotics in the liver.

  5. our results suggest that Nat1 deficiency results in mitochondrial dysfunction, which may constitute a mechanistic link between this gene and insulin resistance .

  6. Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding.(

  7. In adipocytes, Nat1 silencing lowered insulin-mediated glucose uptake, raised lipolysis, and decreased differentiation. Overexpression did the opposite. Nat1(-) mice had high fasting blood glucose, insulin, and triglycerides and low insulin sensitivity.

  8. Transfection assays in mice using hydrodynamics-based procedure and reporter gene assay in a mouse cell line revealed that glucocorticoid-induced NAT gene expression is species dependent

  9. NAT1 affects cell growth and morphology

  10. identification and functional characterization of novel polymorphisms in mice

  11. Biochemical analysis demonstrated that mNAT1 and its evolutionarily conserved co-subunit, mARD1, assemble to form a functional acetyltransferase.

  12. Results suggest that peroxynitrite-dependent inactivation of NAT1 and 2 may contribute to muscle dysfunction by impairing the biotransformation activity of this key cellular defense enzyme system.

Profil protéine NAT1

Profil protéine

This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with NAT1

  • N-acetyltransferase 1 (NAT1)
  • N-acetyl transferase 1 (Nat1)
  • N-acetyltransferase 1 (Nat1)
  • N-acetyltransferase 1 (arylamine N-acetyltransferase) (NAT1)
  • arylamine N-acetyltransferase 1-like (LOC101095575)
  • N-acetyltransferase 1 (arylamine N-acetyltransferase) (Nat1)
  • AAC1 Protéine
  • AT-I Protéine
  • MNAT Protéine
  • Nat Protéine
  • Nat-1 Protéine
  • NAT1 Protéine
  • NATI Protéine

Protein level used designations for NAT1

N-acetyltransferase type 1 , arylamide acetylase 1 , arylamine N-acetyltransferase 1 , monomorphic arylamine N-acetyltransferase , N(alpha)-acetyltransferase 15, NatA auxiliary subunit , N-acetyl transferase 1, liver, blood , AT-1 , N-acetyltransferase (arylamine N-acetyltransferase) , N-acetyltransferase 1 (arylamine N-acetyltransferase) , NAT-1 , MNAT , Arylamide acetylase 1 , Monomorphic arylamine N-acetyltransferase , NAT1 9 , acetyltransferase AT-I , arylamine acetyltransferase

9 Homo sapiens
17960 Mus musculus
116631 Rattus norvegicus
512603 Bos taurus
100328959 Oryctolagus cuniculus
101095575 Felis catus
101840278 Mesocricetus auratus
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