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The protein encoded by NEK1 is a serine/threonine kinase involved in cell cycle regulation. De plus, nous expédions NEK1 Protéines (6) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal NEK1 Primary Antibody pour IF (p), IHC (p) - ABIN872417
Yeo, Becherel, Luff, Graham, Richard, Lavin: Senataxin controls meiotic silencing through ATR activation and chromatin remodeling. dans Cell discovery 2016
NEK1 phosphorylates PP1gamma, leading to the dephosphorylation of WAPL (Montrer WAPAL Anticorps), which, in turn, results in its retention on chromosome cores to promote loss of cohesion at the end of prophase I in mammals.
Reduction in ADD1 (Montrer ADD1 Anticorps) protein in NEK1 mutant mice is associated with hyperphosphorylation of ADD1 (Montrer ADD1 Anticorps), thereby preventing the interaction with MYO10 (Montrer MYO10 Anticorps) during meiotic spindle formation
Nek1 is detectable in all murine tissues but its expression in wild type and kat2J heterozygous kidneys decrease as the kidneys mature. In the embryonic kidney, Nek1 expression is most prominent in cells that will become podocytes and proximal tubules.
results demonstrate that Nek1 is important for proper checkpoint control and characterize for the first time a DNA damage response that does not directly involve one of the known upstream mediator kinases, ATM or ATR
data suggest that TAZ (Montrer TAZ Anticorps) and Nek1 constitute a negative feedback loop linked through phosphorylation and ubiquitination and that the interaction of Nek1 and TAZ (Montrer TAZ Anticorps) maintain polycystin 2 (Montrer PKD2 Anticorps) at the level needed for proper ciliogenesis
NEK1 is required for the maintenance of genome stability by acting at multiple junctures, including control of chromosome stability
Nek1 may function as a kinase early in the DNA damage response pathway.
Murine NIMA-related kinase, Nek1, is larger than previously reported, and that the full-length protein conserves the structural hallmarks of NIMA
Nek1 links cell cycle progression and the primary cilium cycle.
we propose that Nek1 plays a role in centrosome integrity, affecting both ciliogenesis and centrosome stability
Following DNA damage, addition of the TLK1 (Montrer TLK1 Anticorps) inhibitor, THD, or overexpression of NEK1-T141A mutant impaired ATR (Montrer ANTXR1 Anticorps) and Chk1 (Montrer CHEK1 Anticorps) activation, indicating the existence of a TLK1 (Montrer TLK1 Anticorps)>NEK1>ATR (Montrer ANTXR1 Anticorps)>Chk1 (Montrer CHEK1 Anticorps) pathway. Indeed, overexpression of the NEK1-T141A mutant resulted in an altered cell cycle response after exposure of cells to oxidative stress, including bypass of G1 arrest and implementation of an intra S-phase checkpoint.
This study shown that the NEK1 is a novel in patient with familial amyotrophic lateral sclerosis.
Mutation in NEK1 gene is associated with amyotrophic lateral sclerosis.
Nek1 phosphorylates Rad54 (Montrer ATRX Anticorps) and regulates Rad51 (Montrer RAD51 Anticorps) removal to orchestrate homologous recombination and replication fork stability.
Compound heterozygous variants in NEK1 were identified in two brothers with Mohr syndrome. The nonsense variant c.1226G>A, p.(Trp409*), results in nonsense-associated alternative splicing. Ciliation in patient fibroblasts is drastically reduced.
The skeletal phenotype of our patient was milder than those of previously reported cases with NEK1 mutations and those with axial SMD harboring C21orf2 (Montrer C21orf2 Anticorps) mutations. Phenotypes associated with NEK1 mutations are variable and the phenotype-genotype corelation in skeletal ciliopathies is challenging
Nek1 overexpression in gliomas was correlated with the proliferation marker (Ki-67 (Montrer MKI67 Anticorps)), tumor grade, Karnofsky performance scale (KPS) and more importantly, patients' poor survival. Further studies showed that Nek1 expression level was also increased in multiple glioma cell lines (U251-MG, U87-MG, U118, H4 and U373).
C21ORF2 (Montrer C21orf2 Anticorps) functions in the same pathway as NEK1 in DNA damage repair.
Nek1 may facilitate S-phase progression by interacting with Ku80 (Montrer XRCC5 Anticorps) and regulating chromatin loading of replication factors.
Nek1 may suppress cilia by phosphorylating pVHL (Montrer VHL Anticorps), which is critical to microtubule stabilization and ciliary stability.
The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene.
NIMA-related kinase 1
, NY-REN-55 antigen
, Nek1 serine/threonine- and tyrosine-specific protein kinase
, kidney, anemia and testis
, never in mitosis A-related kinase 1
, nimA-related protein kinase 1
, serine/threonine-protein kinase Nek1
, NIMA (never in mitosis gene a)-related kinase 1
, protein-serine/threonine kinase
, renal carcinoma antigen NY-REN-55
, NIMA (never in mitosis gene a)-related expressed kinase 1