anti-NIMA-Related Kinase 1 (NEK1) Anticorps

The protein encoded by NEK1 is a serine/threonine kinase involved in cell cycle regulation. De plus, nous expédions NEK1 Protéines (6) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
NEK1 18004 P51954
NEK1 4750 Q96PY6
NEK1 290705  
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Top anti-NEK1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 40 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Hamster Lapin Inconjugué IHC (p), WB The anti-NEK1 Pab (ABIN392648) is used in Western blot to detect NEK1 in CHO cell lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Connectez-vous pour afficher 10 to 11 Days
$385.00
Détails
Hamster Lapin Inconjugué EIA, IHC (p), WB 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$484.00
Détails
Humain Lapin Inconjugué IHC (p), WB Western Blot at 1:500 dilution + human fetal kidney lysate Lysates/proteins at 20 ug per lane. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. BC = breast carcinoma; HC = hepatocarcinoma. 400 μL Connectez-vous pour afficher 2 to 3 Days
$515.63
Détails
Humain Lapin Inconjugué WB Western Blot: NEK1 Antibody [NBP2-36534] - Samples: Whole cell lysate (50 ug) from HeLa, 293T, Jurkat, mouse TCMK-1, and mouse NIH3T3 cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-NEK1 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 seconds. Western Blot: NEK1 Antibody [NBP2-36534] - Whole cell lysate (50 ug) from HeLa, 293T, and Jurkat cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit antiNEK1 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Connectez-vous pour afficher 7 to 9 Days
$559.35
Détails
Humain Lapin Inconjugué ELISA, WB   100 μL Connectez-vous pour afficher 16 Days
$335.04
Détails
Humain Lapin Inconjugué IF, IHC (p) Immunofluorescent staining of human cell line U-251 MG with NEK1 polyclonal antibody  at 1-4 ug/mL dilution shows positivity in nuclear membrane. Immunohistochemical staining of human breast with NEK1 polyclonal antibody  shows strong cytoplasmic and membranous positivity in glandular cells. 100 μL Connectez-vous pour afficher 11 to 12 Days
$577.33
Détails
Humain Lapin Alexa Fluor 488 IF (p)   100 μL Connectez-vous pour afficher 14 to 21 Days
$428.45
Détails
Humain Lapin HRP IHC (p), WB   100 μL Connectez-vous pour afficher 14 to 21 Days
$428.45
Détails
Humain Lapin Cy7 IF (p)   100 μL Connectez-vous pour afficher 14 to 21 Days
$428.45
Détails
Humain Lapin Cy3 IF (p)   100 μL Connectez-vous pour afficher 14 to 21 Days
$428.45
Détails

anti-NEK1 Anticorps mieux référencés

  1. Hamster Polyclonal NEK1 Primary Antibody pour IHC (p), ELISA - ABIN544240 : Letwin, Mizzen, Motro, Ben-David, Bernstein, Pawson: A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells. dans The EMBO journal 1992 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal NEK1 Primary Antibody pour IF (p), IHC (p) - ABIN872417 : Yeo, Becherel, Luff, Graham, Richard, Lavin: Senataxin controls meiotic silencing through ATR activation and chromatin remodeling. dans Cell discovery 2016 (PubMed)

Plus d’anticorps contre NEK1 partenaires d’interaction

Mouse (Murine) NIMA-Related Kinase 1 (NEK1) interaction partners

  1. NEK1 phosphorylates PP1gamma, leading to the dephosphorylation of WAPL, which, in turn, results in its retention on chromosome cores to promote loss of cohesion at the end of prophase I in mammals.

  2. Reduction in ADD1 protein in NEK1 mutant mice is associated with hyperphosphorylation of ADD1, thereby preventing the interaction with MYO10 during meiotic spindle formation

  3. Nek1 is detectable in all murine tissues but its expression in wild type and kat2J heterozygous kidneys decrease as the kidneys mature. In the embryonic kidney, Nek1 expression is most prominent in cells that will become podocytes and proximal tubules.

  4. results demonstrate that Nek1 is important for proper checkpoint control and characterize for the first time a DNA damage response that does not directly involve one of the known upstream mediator kinases, ATM or ATR

  5. data suggest that TAZ and Nek1 constitute a negative feedback loop linked through phosphorylation and ubiquitination and that the interaction of Nek1 and TAZ maintain polycystin 2 at the level needed for proper ciliogenesis

  6. NEK1 is required for the maintenance of genome stability by acting at multiple junctures, including control of chromosome stability

  7. Nek1 may function as a kinase early in the DNA damage response pathway.

  8. Murine NIMA-related kinase, Nek1, is larger than previously reported, and that the full-length protein conserves the structural hallmarks of NIMA

  9. Nek1 links cell cycle progression and the primary cilium cycle.

  10. we propose that Nek1 plays a role in centrosome integrity, affecting both ciliogenesis and centrosome stability

  11. These data show that Nek1 is important for efficient DNA damage checkpoint control and for proper DNA damage repair.

  12. NEK1 is a candidate to transduce messages from the ciliary-basal body region to the regulation of nuclear gene expression.

Human NIMA-Related Kinase 1 (NEK1) interaction partners

  1. NEK1 kinase domain structure and its dynamic protein interactome after exposure to cisplatin have been reported.

  2. We provide novel evidence for association of NEK1 with ALS in Chinese, reporting variants in these genes not previously found in Europeans.

  3. NEK1 variants may modify disease presentation of driving mutations.

  4. Following DNA damage, addition of the TLK1 inhibitor, THD, or overexpression of NEK1-T141A mutant impaired ATR and Chk1 activation, indicating the existence of a TLK1>NEK1>ATR>Chk1 pathway. Indeed, overexpression of the NEK1-T141A mutant resulted in an altered cell cycle response after exposure of cells to oxidative stress, including bypass of G1 arrest and implementation of an intra S-phase checkpoint.

  5. This study shown that the NEK1 is a novel in patient with familial amyotrophic lateral sclerosis.

  6. Mutation in NEK1 gene is associated with amyotrophic lateral sclerosis.

  7. Nek1 phosphorylates Rad54 and regulates Rad51 removal to orchestrate homologous recombination and replication fork stability.

  8. Compound heterozygous variants in NEK1 were identified in two brothers with Mohr syndrome. The nonsense variant c.1226G>A, p.(Trp409*), results in nonsense-associated alternative splicing. Ciliation in patient fibroblasts is drastically reduced.

  9. The skeletal phenotype of our patient was milder than those of previously reported cases with NEK1 mutations and those with axial SMD harboring C21orf2 mutations. Phenotypes associated with NEK1 mutations are variable and the phenotype-genotype corelation in skeletal ciliopathies is challenging

  10. Nek1 overexpression in gliomas was correlated with the proliferation marker (Ki-67), tumor grade, Karnofsky performance scale (KPS) and more importantly, patients' poor survival. Further studies showed that Nek1 expression level was also increased in multiple glioma cell lines (U251-MG, U87-MG, U118, H4 and U373).

  11. C21ORF2 functions in the same pathway as NEK1 in DNA damage repair.

  12. Nek1 may facilitate S-phase progression by interacting with Ku80 and regulating chromatin loading of replication factors.

  13. Nek1 may suppress cilia by phosphorylating pVHL, which is critical to microtubule stabilization and ciliary stability.

  14. as an ATR-associated kinase, Nek1 enhances the stability and activity of ATR-ATRIP before DNA damage, priming ATR-ATRIP for a robust DNA damage response

  15. The present case provides evidence for a correlation of NEK1 mutation with short rib-polydactyly syndrome type II (Majewski.

  16. This study confirms that NEK1 is one gene causing SRP type II but also reports mutations in DYNC2H1, expanding the phenotypic spectrum of DYNC2H1 mutations.

  17. results demonstrate that Nek1 is important for proper checkpoint control and characterize for the first time a DNA damage response that does not directly involve one of the known upstream mediator kinases, ATM or ATR

  18. absence of functional full-length NEK1 severely reduces cilia number and alters ciliar morphology in vivo.

  19. Nek1 is involved in the beginning of the cellular response to genotoxic stress and plays an important role in preventing cell death induced by DNA damage.

  20. Data report that NEK1 and CLASP2 colocalize with FEZ1 in a perinuclear region in mammalian cells, and observed that coiled-coil interactions occur between FEZ1/CLASP2 and FEZ1/NEK1 in vitro.

NEK1 profil antigène

Profil protéine

The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with NEK1

  • NIMA (never in mitosis gene a)-related expressed kinase 1 (Nek1) anticorps
  • NIMA related kinase 1 (NEK1) anticorps
  • NIMA-related kinase 1 (Nek1) anticorps
  • NIMA-related serine/threonine kinase 1 (NEK1) anticorps
  • ATNEK1 anticorps
  • D8Ertd790e anticorps
  • F20D21.32 anticorps
  • F20D21_32 anticorps
  • kat anticorps
  • NIMA-RELATED KINASE1 anticorps
  • NIMA-related serine/threonine kinase 1 anticorps
  • NY-REN-55 anticorps
  • SRPS2 anticorps
  • SRPS2A anticorps

Protein level used designations for NEK1

NIMA-related kinase 1 , NY-REN-55 antigen , Nek1 serine/threonine- and tyrosine-specific protein kinase , kidney, anemia and testis , never in mitosis A-related kinase 1 , nimA-related protein kinase 1 , serine/threonine-protein kinase Nek1 , NIMA (never in mitosis gene a)-related kinase 1 , protein-serine/threonine kinase , renal carcinoma antigen NY-REN-55 , NIMA (never in mitosis gene a)-related expressed kinase 1

GENE ID SPECIES
18004 Mus musculus
486058 Canis lupus familiaris
4750 Homo sapiens
534671 Bos taurus
290705 Rattus norvegicus
841893 Arabidopsis thaliana
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