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OSBPL5 encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. De plus, nous expédions Oxysterol Binding Protein-Like 5 Protéines (4) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal OSBPL5 Primary Antibody pour ELISA, WB - ABIN188711
Higashimoto, Soejima, Yatsuki, Joh, Uchiyama, Obata, Ono, Wang, Xin, Zhu, Masuko, Ishino, Hatada, Jinno, Iwasaka, Katsuki, Mukai: Characterization and imprinting status of OBPH1/Obph1 gene: implications for an extended imprinting domain in human and mouse. dans Genomics 2002
Show all 2 Pubmed References
imprinting status of four cattle genes (Tssc4 (Montrer TSSC4 Anticorps),Nap1l4 (Montrer NAP1L4 Anticorps), Phlda2 (Montrer PHLDA2 Anticorps) and Osbpl5) in seven types of tissues, were assessed in cattle.
ORP5/8 are endoplasmic reticulum (ER) membrane proteins implicated in lipid trafficking that localize to ER-plasma membrane (PM) contacts and maintain membrane homeostasis. Here the authors show that PtdIns(4,5)P 2 plays a critical role in the targeting and function of ORP5/8 at the PM.
mammalian ORP5 and ORP8 (Montrer OSBPL8 Anticorps) proteins localize to ER-mitochondrial MCS (Montrer SMCP Anticorps), in addition to ER-PM contact sites.
Results show that OSBPL5 and CALU (Montrer CALU Anticorps) were expressed at higher levels in the lung tissues of metastasis-positive cases than that in the metastasis-negative cases suggesting they can promote invasiveness of lung cancer cells.
ORP5 and ORP8 (Montrer OSBPL8 Anticorps) could mediate PI4P/phosphatidylserine (PS) countertransport between the endoplasmic reticulum (ER) and the plasma membrane (PM), thus delivering PI4P to the ER-localized PI4P phosphatase Sac1 (Montrer SACM1L Anticorps) for degradation and PS from the ER to the PM.
ORP5 may cooperate with NPC1 (Montrer NPC1 Anticorps) to mediate the exit of cholesterol from endosomes/lysosomes.
OBPH1/Obph1 gene is imprinted, with preferential expression from the maternal allele in human and mouse.
Telomeric NAP1L4 (Montrer NAP1L4 Anticorps) and OSBPL5 of the KCNQ1 (Montrer KCNQ1 Anticorps) cluster, and the DECORIN (Montrer DCN Anticorps) gene are not imprinted in human trophoblast stem cells.
OSBPL5 is relatd to invasion and poor prognosis in pancreatic cancer.
OSBP (Montrer OSBP Anticorps) regulates hepatic TG metabolism and suggest the involvement of OSBP (Montrer OSBP Anticorps) in the insulin (Montrer INS Anticorps) signaling pathways that control hepatic lipogenesis.
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. This gene has been shown to be imprinted, with preferential expression from the maternal allele only in placenta. Transcript variants encoding different isoforms have been identified.
oxysterol binding protein-like 5
, oxysterol-binding protein-related protein 5-like
, OSBP-related protein 5
, oxysterol-binding protein homolog 1
, oxysterol-binding protein homologue 1
, oxysterol-binding protein-related protein 5
, oxysterol binding protein 2
, oxysterol binding protein homolog 1
, oxysterol-binding protein-like protein 5