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Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. De plus, nous expédions Perilipin 3 Anticorps (197) et Perilipin 3 Kits (6) et beaucoup plus de produits pour cette protéine.
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These data suggest that Plin3 acts as an intrinsic protective factor preventing futile beige adipocyte formation by limiting lipid metabolism and thermogenic gene expression.
our studies demonstrate that the lipid droplets (LDs) scaffold protein (Montrer HOMER1 Protéines), PLIN3, is essential for HCV core-induced hepatic steatosis and provide new insights into the pathogenesis of HCV.
Postprandial triglyceride rich lipoproteins may be involved in atherosclerotic plaque formation through the regulation of perilipin-2 (Montrer PLIN2 Protéines) and perilipin-3 proteins in macrophages.
Collectively these data suggest that whereas perilipin 1 (Montrer PLIN1 Protéines) potently suppresses basal lipolysis in adipocytes, perilipins 2 and 3 facilitate higher rates of basal lipolysis
Data indicate that PLIN2 (Montrer PLIN2 Protéines) and PLIN3 may participate in acute lipid droplet formation in mammalian testes.
These findings show that TIP47 affects hepatic lipid and glucose metabolism and may be a target for the treatment of nonalcoholic fatty liver and related metabolic disorders.
Overexpression of tail interacting protein of 47 kDa (TIP47), but not i (Montrer SQSTM1 Protéines)ts truncated form (t-TIP47) protected NIH3T3 cells from hydrogen-peroxide-induced cell death, prevented the hydrogen-peroxide-induced mitochondrial depolarization.
the non-lipid droplet pools of S3-12 (Montrer PLIN4 Protéines), adipophilin (Montrer PLIN2 Protéines), and TIP47 constitute a ready reservoir of coat proteins to permit rapid packaging of newly synthesized triacylglycerol and to maximize energy storage during nutrient excess
Adipophilin (Montrer PLIN2 Protéines) and TIP47 are expressed in LDs of vitamin A-storing hepatic stellate cells and additionally in lipid droplets of steatotic hepatocytes.
Data establish an important role for Tip47 proteins as surfactant at the LD surface, packaging lipids in smaller units and restricting access of lipases and thus preventing insulin (Montrer INS Protéines) resistance.
we found a DPP9 (Montrer DPP9 Protéines)-PPP6R3 (Montrer PPP6R3 Protéines) fusion transcript in one tumor showing a matching genomic 11;19-translocation. Another tumor had a rearrangement of DPP9 (Montrer DPP9 Protéines) with PLIN3. Both rearrangements were associated with diminished expression of the 3' end of DPP9 (Montrer DPP9 Protéines) corresponding to the breakpoints identified by RNA-seq.
Conserved amphipathic helices mediate lipid droplet targeting of PLIN1 (Montrer PLIN1 Protéines), PLIN2 (Montrer PLIN2 Protéines), and PLIN3.
PLIN3 functions are intertwined with the lipogenic pathways implicated in sebaceous lipogenesis, such as desaturation and triglyceride synthesis.
Differential expression of PLIN3 and brefeldin A sensitivity may explain differential lipid oxidation efficiency in skeletal muscle among healthy lean, sedentary, and T2 diabetic males.
Results indicate that microRNAs miR (Montrer MLXIP Protéines)-148a and miR (Montrer MLXIP Protéines)-30a, regulate Tail interacting protein of 47 kDa (TIP47) expression and lipid droplets (LD) in hepatitis C virus infected cells.
Following exercise training, perilipin 3 protein expression was increased in the adipose tissue of women with polycystic ovary syndrome.
Skeletal muscle perilipin 3 and coatomer (Montrer ARCN1 Protéines) proteins are increased following exercise and are associated with fat oxidation.
Rab9 (Montrer RAB9A Protéines)-complexed TIP47 plays an essential role for the proper release of hepatitis C viral particles.
PLIN3 is associated with the synthesis and secretion of PGE2
PLIN3 expression in cumulus cells and oocytes during in vitro maturation.
This work describes the cloning and sequencing of porcine PLIN (Montrer PLIN1 Protéines) and M6PRBP1 cDNAs, the chromosome mapping of these two genes, as well as the expression pattern of porcine PAT genes.
Adipophilin (Montrer PLIN2 Protéines) and TIP47 are expressed in lipid droplets of vitamin A-storing hepatic stellate cells and additionally in lipid droplets of steatotic hepatocytes.
Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.
cargo selection protein TIP47
, mannose-6-phosphate receptor binding protein 1
, mannose-6-phosphate receptor-binding protein 1
, 47 kDa MPR-binding protein
, placental protein 17
, tail-interacting protein, 47 kD
, perilipin 3
, 47 kDa tail interaction protein
, mannose 6 phosphate receptor binding protein 1
, Mannose-6-phosphate receptor-binding protein 1