Protein Phosphatase 4, Catalytic Subunit Protéines (PPP4C)

Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. De plus, nous expédions PPP4C Anticorps (130) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
PPP4C 5531 P60510
PPP4C 56420 P97470
PPP4C 171366 Q5BJ92
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Top PPP4C Protéines sur anticorps-enligne.fr

Showing 10 out of 13 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,749.58
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,749.58
Détails
Escherichia coli (E. coli) Humain His tag 100 μg Connectez-vous pour afficher 13 to 16 Days
$400.00
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
Escherichia coli (E. coli) Humain His tag Validation with Western Blot 50 μg Connectez-vous pour afficher 11 Days
$291.50
Détails
Levure Boeuf (Vache) His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,816.00
Détails
Levure Lapin His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,816.00
Détails
Levure Orang-Utan His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,816.00
Détails
Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,816.00
Détails
Levure Yeast His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,821.50
Détails

PPP4C Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Plus protéines pour Protein Phosphatase 4, Catalytic Subunit (PPP4C) partenaires d'interaction

Zebrafish Protein Phosphatase 4, Catalytic Subunit (PPP4C) interaction partners

  1. Protein phosphatase 4 cooperates with Smads to promote BMP signaling in dorsoventral patterning of zebrafish embryos

Human Protein Phosphatase 4, Catalytic Subunit (PPP4C) interaction partners

  1. PP4 regulates breast cancer cell survival and identifies a novel PP4c-PEA15 signalling axis in the control of breast cancer cell survival.

  2. Knockdown of Alpha4 preferentially impacts the expression of PP4c and PP6c compared to expression levels of PP2Ac.

  3. Data show that protein phosphatase 4 catalytic subunit (PP4C) knockdown decreases glioma cell proliferation.

  4. mutual regulatory mechanisms exist between PP4 and SAF-A. Interactions between PP4 and SAF-A played a role in prometaphase/metaphase transition.

  5. These data suggested a potential role of PP4C in tumor progression.

  6. Stathmin plays an essential role of in Merkel cell polyomavirus small tumor antigen-mediated microtubule destabilization and cell motility and this process is regulated by cellular phosphatase catalytic subunit of protein phosphatase 4.

  7. PP4 and Wip1 are differentially required to counteract the p53-dependent cell cycle arrest in G1 and G2, by antagonizing early or late p53-mediated responses, respectively

  8. Results show PP4C as a fostriecin-sensitive phosphatase and demonstrate that the suppression of PP4C triggers mitotic slippage/apoptosis.

  9. Data indicate that the major phosphatase responsible for dephosphorylation of of BAF Ser-4 to be protein phosphatase 4 catalytic subunit.

  10. Recombinant gamma-tubulin can be phosphorylated by Cdk1-cyclin B or Brsk1 and dephosphorylated by Ppp4c-R2-R3A in vitro.

  11. PP4c is a key regulator of cortical development that changes the orientation of progenitor division responsible for the transition between symmetric and asymmetric cell division.

  12. Overexpression of PP4C is associated with poor prognosis in patients with stage II pancreatic ductal adenocarcinoma.

  13. PP4R1 and PP4c Cooperate to Catalyze IKK Dephosphorylation

  14. PP4C and KAP1 are in the same epistasis group, and PP4 is involved in NHEJ-mediated DSB repair, possibly through regulating the phosphorylation status of KAP1.

  15. The authors devised a novel proteomic strategy for systematic identification of proteins dephosphorylated by PP4C and identified KRAB-domain-associated protein 1 (KAP-1) as a substrate.

  16. PP4R2, a regulatory subunit of PP4, mediates the DNA damage-dependent association between RPA2 and the PP4C catalytic subunit.

  17. Protein phosphatase 4 interacts with the Survival of Motor Neurons complex and enhances the temporal localisation of snRNPs

  18. protein phosphatase 4 has a role in NF-kappaB p65 Thr dephosphorylation

  19. IRS-4 is subject to regulation by TNF-alpha, and PP4 mediates TNF-alpha-induced degradation of IRS-4

  20. PP4 is a positive regulator for HPK1 and the HPK1-JNK signaling pathway

Mouse (Murine) Protein Phosphatase 4, Catalytic Subunit (PPP4C) interaction partners

  1. LCMT-1 homozygous knock-out MEFs exhibited hyperphosphorylation of HDAC3, a reported target of the methylation-dependent PP4R1-PP4c complex. Collectively, our data suggest that LCMT-1 coordinately regulates the carboxyl methylation of PP2A-related phosphatases and, consequently, their holoenzyme assembly and function.

  2. T cell-specific ablation of PP4 resulted in defective adaptive immunity, impaired T cell homeostatic expansion, and inefficient T cell proliferation.

  3. Data show that protein phosphatase 4 (PP4) is an important regulator in inflammatory related insulin resistance.

  4. Thus, serine/threonine phosphatase PP4 functions as a novel feedback negative regulator of RNA virus-triggered innate immunity.

  5. Taken together, our results establish a novel role for PP4 in CSR, and reveal crucial functions for PP4 in the maintenance of genomic stability, GC formation, and B cell-mediated immune responses.

  6. PP4 overexpression was observed to lead to a decreased pACC1Ser79/ACC1 ratio and subsequently an increased intracellular triglyceride content in mouse primary hepatocytes.

  7. Mammalian SMEK/PP4C proteins are involved in the regulation of hepatic glucose metabolism through dephosphorylation of CRTC2.

  8. Protein phosphatase 4 has a role in apoptosis.

  9. PP4 is essential for thymocyte development and pre-TCR signaling

  10. PP4 negatively regulated LPS-induced and TRAF6-mediated NF-kappaB activation by inhibiting the ubiquitination of TRAF6.

Profil protéine PPP4C

Profil protéine

Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.

Gene names and symbols associated with PPP4C

  • protein phosphatase 4 catalytic subunit (ppp4c)
  • protein phosphatase 4, catalytic subunit a (ppp4ca)
  • protein phosphatase 4 catalytic subunit (PPP4C)
  • protein phosphatase 4, catalytic subunit (Ppp4c)
  • protein phosphatase 4 catalytic subunit S homeolog (ppp4c.S)
  • 1110002D08Rik Protéine
  • AU016079 Protéine
  • gc:56413 Protéine
  • MGC75928 Protéine
  • PP4 Protéine
  • PP4C Protéine
  • PP4C-A Protéine
  • PPH3 Protéine
  • PPP4 Protéine
  • ppp4c Protéine
  • Ppx Protéine
  • wu:fd05e08 Protéine
  • zgc:56413 Protéine

Protein level used designations for PPP4C

protein phosphatase 4, catalytic subunit , catalytic subunit , serine/threonine-protein phosphatase 4 catalytic subunit A , PP-X , protein phosphatase 4 (formerly X), catalytic subunit , protein phosphatase X, catalytic subunit , serine/threonine-protein phosphatase 4 catalytic subunit , PP4C , pp4 , protein phosphatase X

GENE ID SPECIES
394540 Xenopus (Silurana) tropicalis
100003080 Danio rerio
5531 Homo sapiens
540398 Bos taurus
56420 Mus musculus
171366 Rattus norvegicus
489947 Canis lupus familiaris
100009163 Oryctolagus cuniculus
432334 Xenopus laevis
100173513 Pongo abelii
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