PPP4C Protéines

Profil protéine

Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.

Gene names and symbols associated with PPP4C

• protein phosphatase 4 catalytic subunit (ppp4c) anticorps
• protein phosphatase 4, catalytic subunit a (ppp4ca) anticorps
• protein phosphatase 4 catalytic subunit (PPP4C) anticorps
• protein phosphatase 4, catalytic subunit (Ppp4c) anticorps
• protein phosphatase 4 catalytic subunit S homeolog (ppp4c.S) anticorps

• 1110002D08Rik anticorps
• AU016079 anticorps
• gc:56413 anticorps
• MGC75928 anticorps
• PP4 anticorps
• Afficher tous les alias de synonymes
• PP4C anticorps
• PP4C-A anticorps
• PPH3 anticorps
• PPP4 anticorps
• ppp4c anticorps
• Ppx anticorps
• wu:fd05e08 anticorps
• zgc:56413 anticorps

Protein level used designations for PPP4C

protein phosphatase 4, catalytic subunit , catalytic subunit , serine/threonine-protein phosphatase 4 catalytic subunit A , PP-X , protein phosphatase 4 (formerly X), catalytic subunit , protein phosphatase X, catalytic subunit , serine/threonine-protein phosphatase 4 catalytic subunit , PP4C , pp4 , protein phosphatase X