anti-Protein Tyrosine Phosphatase Type IVA, Member 3 (PTP4A3) Anticorps

The protein encoded by PTP4A3 belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). De plus, nous expédions PTP4A3 Protéines (11) et PTP4A3 Kits (7) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
PTP4A3 11156 O75365
PTP4A3 19245 Q9D658
PTP4A3 362930  
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Top anti-PTP4A3 Anticorps sur anticorps-enligne.fr

Showing 10 out of 85 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-PTP4A3 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  293T cell lysate PTP4A3 is supported by BioGPS gene expression data to be expressed in HEK293T 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-PTP4A3 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  ACHN cell lysate WB Suggested Anti-PTP4A3  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: ACHN cell lysate 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué EIA, WB 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$484.00
Détails
Humain Lapin Inconjugué WB Western blot analysis of PTP4A3 C-term (ABIN392855) in MCF-7 and 293 cell line lysates (35 µg/lane). PTP4A3 (arrow) was detected using the purified polyclonal antibody. 400 μL Connectez-vous pour afficher 10 to 11 Days
$385.00
Détails
Poulet Lapin Inconjugué WB 50 μg Connectez-vous pour afficher 11 to 14 Days
$551.83
Détails
Chien Lapin Inconjugué WB 50 μg Connectez-vous pour afficher 11 to 14 Days
$551.83
Détails
Humain Lapin Inconjugué ELISA, IHC, WB Western blot analysis of Hepg2 whole cell lysates, using PTP4A3 Antibody. The lane on the left is treated with the antigen-specific peptide. Western blot analysis of extracts from rat heart ,rat spleen and rat brain, using PTP4A3 Antibody. 100 μL Connectez-vous pour afficher 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué EIA, WB 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$484.00
Détails
Humain Souris Inconjugué WB The monoclonal antibody anti-PRL3 (ABIN387832) is used in Western blot to detect PRL3 in 293 cells transfected with PRL3. 400 μL Connectez-vous pour afficher 10 to 11 Days
$385.00
Détails
Humain Lapin Inconjugué WB Western blot analysis of PRL3 Antibody (ABIN392854) in mouse heart tissue lysates (35 µg/lane). PRL3 (arrow) was detected using the purified polyclonal antibody. 400 μL Connectez-vous pour afficher 10 to 11 Days
$385.00
Détails

anti-PTP4A3 Anticorps mieux référencés

  1. Human Polyclonal PTP4A3 Primary Antibody pour ELISA - ABIN545046 : Bardelli, Saha, Sager, Romans, Xin, Markowitz, Lengauer, Velculescu, Kinzler, Vogelstein: PRL-3 expression in metastatic cancers. dans Clinical cancer research : an official journal of the American Association for Cancer Research 2003 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal PTP4A3 Primary Antibody pour ELISA - ABIN545045 : Kim, Song, Jee, Sheen, Lee, Lee, Ro, Cho, Lee, Yamazaki, Jeon, Cheong: Structure of human PRL-3, the phosphatase associated with cancer metastasis. dans FEBS letters 2004 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal PTP4A3 Primary Antibody pour ELISA, WB - ABIN564844 : Fromont, Godet, Peyret, Irani, Celhay, Rozet, Cathelineau, Cussenot: 8q24 amplification is associated with Myc expression and prostate cancer progression and is an independent predictor of recurrence after radical prostatectomy. dans Human pathology 2013 (PubMed)

Plus d’anticorps contre PTP4A3 partenaires d’interaction

Human Protein Tyrosine Phosphatase Type IVA, Member 3 (PTP4A3) interaction partners

  1. Here, we identified Leo1 as a direct and specific substrate of PRL-3. Serine-dephosphorylated form of Leo1 binds directly to beta-catenin, promoting the nuclear accumulation of beta-catenin and transactivation of TCF/LEF downstream target genes such as cyclin D1 and c-myc

  2. PRL3 has magnesium-sensitive phosphatase activity with ATP and other nucleotides.

  3. PRL-3 promotes glioblastoma progression by enhancing MMP7 through the ERK and JNK pathways.

  4. The expression of PRL-3 was significantly increased in HCC tissues and cells at both protein and mRNA levels (P<0.01 for all). Furthermore, the up-regulation of PRL-3 was positively correlated with hepatic vascular invasion (P=0.019), lymph node metastasis (P=0.012), and TNM stage (P=0.001).

  5. PRL-3 may be a reliable biomarker for early prostate cancer detection and may provide a predictive indicator of tumor progression

  6. The proliferation and invasion of colorectal cancer cells were enhanced significantly by PRL-3 through improving glycolysis.

  7. We conclude that PRL-3 is an important regulatory factor for breast cancer cell proliferation and invasion. Loss of PRL-3 function induces an antimetastatic gene expression profile in breast cancer cells. Due to its role in tumor growth and metastasis, PRL-3 emerges as a new therapeutic target in breast cancer therapy.

  8. Since high PRL-3 expression also correlates with poor prognosis in other cancers and functional studies in PC support these findings, PRL-3 emerges as a potential treatment target in PC

  9. Data show that phosphatase of regenerating liver-3 (PRL-3a) is an important mediator of growth factor signaling in MM cells and hence possibly a good target for treatment of MM.

  10. Data suggest that phosphatase of regenerating liver-3 (PRL-3)might play a tumor suppressor role in lung cancer, distinct from other cancers, by inhibiting epithelial-mesenchymal transition (EMT)-related pathways.

  11. A novel role of PRL-3 in tumor development through its adverse impact on telomere homeostasis.

  12. our result indicated that PRL-3 promotes protein phosphorylation by acting as an 'activator kinase' and consequently regulates cytokine secretion.

  13. The disruption of epithelial architecture by PRL-3 revealed here is a newly recognized mechanism for PRL-3-promoted cancer progression.

  14. This study suggests PRL-3 and SFKs are key mediators of the IL6-driven signaling events.

  15. Regulation of PTP4A3 expression is altered in specific subgroups of acute leukemias and this is likely brought about by expression of the aberrant ETV6-RUNX1 and BCR-ABL1 fusion genes.

  16. PRL-3 engages the focal adhesion pathway in trip0le-negative breast cancer cells as a key mechanism for promoting TNBC cell migration and invasion.

  17. PTP4A3 regulated glioblastoma multiforme via miR-137-mediated Akt/mTOR signaling pathway.

  18. Studies suggest that transcriptional, translational, or posttranslational regulation might be involved in the aberrant expression of phosphatase of regenerating liver (PRL)-3.

  19. we observed that PRL-3 regulated the clustering of integrin beta1 in FAs on collagen I but not on fibronectin. This work identifies PRL-3 as a new regulator of cell adhesion structures to the extracellular matrix, and further supports PRL-3 as a key actor of metastasis in uveal melanoma, of which molecular mechanisms are still poorly understood

  20. PTP4A3 may play a role in bladder cancer oncogenesis and is a predictive marker of metastasis. PTP4A3 overexpression represents an independent prognosticator for BC, suggesting its potential theranostic value.

Zebrafish Protein Tyrosine Phosphatase Type IVA, Member 3 (PTP4A3) interaction partners

  1. Results uncovered that aberrant overexpression of PRL-3 could initiate chordoma in early development.

Xenopus laevis Protein Tyrosine Phosphatase Type IVA, Member 3 (PTP4A3) interaction partners

  1. Data show that protein-tyrosine phosphatase PRP4A3 (prl3) and van gogh like1 (vangl1) are Necessary Components in prohibitin1 (phb1) dependent neural crest specification.

  2. PTP4A3 is required for cephalic neural crest migration in vivo during embryonic development.

Mouse (Murine) Protein Tyrosine Phosphatase Type IVA, Member 3 (PTP4A3) interaction partners

  1. our results suggest that the Prl3b1-cre mice line provides a unique resource to understand testicular germ-cell development

  2. Results demonstrate that Ptp4a3 contributes to the malignant phenotype of tumor-initiating cells.

  3. PRL-3 protein was significantly reduced in mouse STAT3-knockout liver cells compared with STAT3-wild type counterparts, and ectopic expression of STAT3 in these cells led to a pronounced increase in PRL-3 protein.

  4. Data indicate that Mycobacterium tuberculosis T cell stimulatory epitope (MT) is a potentially effective molecular adjuvant in preparation of monoclonal antibody (mAb) specific for phosphatase of regenerating liver-3 (PRL-3).

  5. These findings strongly support a role for PTP4A3 as an important contributor to endothelial cell function and as a multimodal target for cancer therapy and mitigating VEGF-regulated angiogenesis.

  6. the first definitive evidence implicating Ptp4a3 in colon tumorigenesis

  7. role of PTP4A3 in acute myeloid leukemia

  8. PTP4A3 was identified as a novel negative regulator of LPS-induced LITAF/TNF-alpha production.

  9. PRL-3 was highly expressed in metastatic melanoma B16-BL6 cells but not in its lowly metastatic parental cell line, B16 cells

  10. PRL-3-expressing cells rapidly induce metastatic tumor formation in lung

  11. expression is associated with gastric cancer metastases

  12. PRL-3 was shown to be expressed in the total mouse bone marrow fraction and more intensely in the Ter119-positive (pre-erythrocyte) fraction but not in the CD61-positive (megakaryocyte)fraction.

  13. Results suggest that Prl-3 plays a critical role in promoting the process of sponatneous metastasis and tumor growth initiation, and that inhibiting Prl-3 will improve melanoma therapy.

  14. Results identify Prl-3 (phosphatase of regenerating liver-3) as a p53-inducible gene, and demonstrate that Prl-3 is an important cell-cycle regulator.

PTP4A3 profil antigène

Profil protéine

The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist.

Gene names and symbols associated with PTP4A3

  • protein tyrosine phosphatase type IVA, member 3 (PTP4A3) anticorps
  • protein tyrosine phosphatase type IVA, member 3 (ptp4a3) anticorps
  • protein tyrosine phosphatase type IVA, member 3 L homeolog (ptp4a3.L) anticorps
  • protein tyrosine phosphatase 4a3 (Ptp4a3) anticorps
  • protein tyrosine phosphatase type IVA, member 3 (Ptp4a3) anticorps
  • AV088979 anticorps
  • pPtp4a3 anticorps
  • Prl-3 anticorps
  • PRL-R anticorps
  • prl3 anticorps
  • PTP4A3 anticorps
  • ptpcaax3 anticorps
  • wu:fc54b05 anticorps
  • wu:fv52d11 anticorps
  • zgc:77109 anticorps

Protein level used designations for PTP4A3

potentially prenylated protein tyrosine phosphatase , protein tyrosine phosphatase type IVA 3 , protein-tyrosine phosphatase 4a3 , protein-tyrosine phosphatase of regenerating liver 3 , PRL-3 , fc54b05 , fv52d11 , xPRL-3 , protein tyrosine phosphatase type IVA, member 3 , protein tyrosine phosphatase 4a3

GENE ID SPECIES
11156 Homo sapiens
406460 Danio rerio
432351 Xenopus laevis
606961 Canis lupus familiaris
737820 Pan troglodytes
768713 Gallus gallus
100137722 Bos taurus
100216017 Xenopus (Silurana) tropicalis
100342107 Oryctolagus cuniculus
19245 Mus musculus
362930 Rattus norvegicus
100724863 Cavia porcellus
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