Proteolipid Protein 1 Protéines (PLP1)

PLP1 encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system.

afficher tous les protéines Gène GeneID UniProt
Humain PLP1 PLP1 5354 P60201
Rat PLP1 PLP1 24943 P60203
Souris PLP1 PLP1 18823 P60202
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
Cellules d'insectes Humain Inconjugué „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 50 to 55 Days
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
Escherichia coli (E. coli) Humain His tag   100 μg Connectez-vous pour afficher 15 to 18 Days
Synthetic Humain Inconjugué   50 μg Connectez-vous pour afficher 3 to 4 Days

Plus protéines pour Proteolipid Protein 1 (PLP1) partenaires d'interaction

Human Proteolipid Protein 1 (PLP1) interaction partners

  1. Authors investigated the disease progression in mouse models carrying PLP1 point mutations previously found in patients displaying clinical features of multiple sclerosis. These mouse models show loss-of-function of PLP1 associated with neuroinflammation.

  2. Review focusing on sequences in hPLP1 intron 1 DNA deemed important for hPLP1 gene activity as well as a couple of "human-specific" supplementary exons within the first intron which are utilized to generate novel splice variants, and the potential role that these sequences may play in PLP1-linked disorders.

  3. it seems that the epitopes of some microorganisms mimicking PLP such as PLP58-74 might have a potential role in the initiation of Multiple Sclerosis.

  4. Human induced pluripotent stem cells-derived oligodendrocytes from 12 individuals with Pelizaeus-Merzbacher and identified individual and shared defects in PLP1 mRNA expression and splicing, oligodendrocyte progenitor development, and oligodendrocyte morphology and capacity for myelination.

  5. report a novel mutation of the PLP1 gene in two siblings with Pelizaeus-Merzbacher disease associated with a rare and protean neuroimaging finding of optic nerve enlargement

  6. Identification and functional study of novel PLP1 mutations in Chinese patients with Pelizaeus-Merzbacher disease. We identified PLP1 mutations in seven male patients with PMD.

  7. In major depressive disorder there was a significantly reduced expression of PLP1 mRNA.

  8. Study investigated 17 unrelated Pelizaeus-Merzbacher disease subjects with copy number gains at the PLP1 locus including triplication and quadruplication of specific genomic intervals-16/17 were found to have a duplication-inverted triplication-duplication rearrangement product.

  9. Myelin proteolipid protein is critical to regulating oligodendrocyte progenitor cell migration.

  10. PLP1 splicing mutations may result in a wide variety of disease phenotypes through a combination of multiple molecular pathogenic mechanisms.

Mouse (Murine) Proteolipid Protein 1 (PLP1) interaction partners

  1. This study demonstrated that Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2.

  2. The rumpshaker missense mutation in the Plp1 gene gives rise to subcortical myoclonus

  3. axonal mitochondria, smooth endoplasmic reticulum, and microtubules were characterized in rodent optic nerves where PLP (Montrer C3 Protéines) is replaced by the peripheral nerve myelin protein, P0.

  4. The observations collectively support the idea that GST-pi (Montrer GSTP1 Protéines)(Nuc (Montrer SREBF2 Protéines))/DM-20 mRNA-expressing cells are the progeny of NG2 (Montrer Vcan Protéines)-positive OPCs rather than a novel type of oligodendrocyte-lineage progenitor cells and that DM-20 mRNA expression is dynamically regulated during differentiation of OPCs into oligodendrocytes.

  5. In the absence of P0, thus, PLP (Montrer C3 Protéines) also contributes to myelination by Schwann cells and to the preservation of peripheral axons

  6. while PLP (Montrer C3 Protéines) can co-exist with P0 in peripheral nervous system(PNS) myelin, PLP (Montrer C3 Protéines) cannot replace P0 as the major structural protein of PNS myelin.

  7. Both extracellular and intracellular epitopes of PLP (Montrer C3 Protéines) contribute to the pathogenesis of MP4-induced experimental autoimmune encephalomyelitis already in the setting of intact myelin.

  8. The insertion of native PLP (Montrer C3 Protéines) into Olg mitochondria of animals with PLP1/Plp1 regulates extracellular pH and adenosine triphosphate.

  9. This study shows for the first time that Plp (Montrer C3 Protéines)-null mice exhibit severe early-onset thermal hyperalgesia that is not associated with changes in thermal allodynic behavior.

  10. A novel mechanism sheds light on the immune regulation by which sulfatide-reactive type II natural killer (NK)T cells suppress inflammatory class II histocompatibility-restricted pathogenic CD4 (Montrer CD4 Protéines)+ T cell responses in a T cell-mediated autoimmune disease.

Profil protéine Proteolipid Protein 1 (PLP1)

Profil protéine

This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.

Gene names and symbols associated with Proteolipid Protein 1 Protéines (PLP1)

  • proteolipid protein 1 (PLP1)
  • proteolipid protein 1 (Plp1)
  • proteolipid protein 1 (plp1)
  • proteolipid protein (myelin) 1 (Plp1)
  • myelin proteolipid protein (Tsp_11640)
  • myelin proteolipid protein (plp)
  • proteolipid protein 1 L homeolog (plp1.L)
  • proteolipid protein 1a (plp1a)
  • DKFZp459O081 Protéine
  • DKFZp459O113 Protéine
  • DM20 Protéine
  • DMalpha2c Protéine
  • GPM6C Protéine
  • hld1 Protéine
  • jimpy Protéine
  • jp Protéine
  • mmpl Protéine
  • msd Protéine
  • plp Protéine
  • PLP/DM20 Protéine
  • plp1 Protéine
  • plp1a Protéine
  • pmd Protéine
  • rsh Protéine
  • spg2 Protéine
  • wu:fc27f01 Protéine
  • wu:fj36d03 Protéine
  • wu:fj42d08 Protéine
  • zgc:110499 Protéine

Protein level used designations for Proteolipid Protein 1 Protéines (PLP1)

lipophilin , major myelin proteolipid protein , myelin proteolipid protein , Proteolipid protein (Pelizaeus-Merzbacher disease spastic paraplegia 2 uncomplicated) , Proteolipid protein (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated) , proteolipid protein (myelin) 1 , proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated) , proteolipid protein, lipophilin , proteolipid protein 1 , myelin synthesis deficiency , rump shaker , PLP , PLP-A , lipophilin-A , myelin proteolipid protein (PLP) , myelin proteolipid protein A , proteolipid protein 1 a , DMalpha1 , etID60288.14

5354 Homo sapiens
24943 Rattus norvegicus
281410 Bos taurus
397029 Sus scrofa
465785 Pan troglodytes
481002 Canis lupus familiaris
613099 Xenopus (Silurana) tropicalis
100009169 Oryctolagus cuniculus
100173486 Pongo abelii
100174736 Pongo abelii
18823 Mus musculus
396214 Gallus gallus
10903177 Trichinella spiralis
100136749 Oncorhynchus mykiss
398334 Xenopus laevis
100220245 Taeniopygia guttata
64264 Danio rerio
100714212 Cavia porcellus
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