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The protein encoded by RAD17 is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. De plus, nous expédions RAD17 Homolog (S. Pombe) Anticorps (193) et RAD17 Homolog (S. Pombe) Kits (4) et beaucoup plus de produits pour cette protéine.
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a mutant Rad17 pathway is associated with a general deregulation of DNA repair, which seems to be correlated with a deficiency in non-homologous double strand break repair.
The Rad17 C-terminal tail is a molecular switch that regulates the 9-1-1 interaction and the ATR pathway.
These data indicate that the interaction with the 9-1-1 complex is not required for Rad17 protein to be an efficient substrate for the UV-induced phosphorylation. Our data also raise the possibility that the 9-1-1 complex plays a negative regulatory role in the Rad17 phosphorylation. We also show that the nucleotide-binding activity of Rad17 is required for its nuclear localization.
In a Japanese population, the variant allele of hRAD17 is significantly associated with a decreased risk of Colorectal Cancer among light smokers and rectal cancer patients and with an increased risk of Colorectal Cancer among heavy smokers.
Authors show that BRCA1 and RAD17 genes, whose derived proteins play a pivotal role in DNA damage repair, are transcriptional targets of gain-of-function mutant p53 (Montrer TP53 Protéines) proteins.
USP20 (Montrer USP20 Protéines) and Rad17 interact, and that this interaction is enhanced by UV exposure. We show that USP20 (Montrer USP20 Protéines) regulation of Rad17 is at the protein level in a proteasome-dependent manner. USP20 (Montrer USP20 Protéines) depletion results in poor activation of Chk1 (Montrer CHEK1 Protéines) protein by phosphorylation
These data suggest that v-Src (Montrer SRC Protéines) attenuates ATR (Montrer ANTXR1 Protéines)-Chk1 (Montrer CHEK1 Protéines) signaling through the inhibition of Rad17-Rad9 (Montrer RAD9A Protéines) interaction.
Rad17 is phosphorylated by ATM (Montrer ATM Protéines) at Thr622 resulting in a direct interaction of Rad17 with NBS1 (Montrer NBN Protéines), facilitating recruitment of MRE11 (Montrer MRE11A Protéines), RAD50 (Montrer RAD50 Protéines) and ATM (Montrer ATM Protéines) to the DNA double-strand breaks.
Our data suggest RAD17 as a novel target protein for gemcitabine combination therapy supplementing or complementing inhibition of CHK1 (Montrer CHEK1 Protéines).
Knockdown of Rad17 with two independent siRNAs significantly reduced Chk1 (Montrer CHEK1 Protéines) phosphorylation and substantial RPA32 (Montrer RPA2 Protéines) Ser33 phosphorylation.
Data indicate that regulation of Rad17 turnover is through the Cdh1 (Montrer CDH1 Protéines)/anaphase-promoting complex pathway in breast cancer cells.
targeted deletion of an N-terminal part of mRad17, the mouse homolog of the Schizosaccharomyces pombe Rad17 checkpoint clamp-loader component, resulted in embryonic lethality during early/mid-gestation
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.
RAD17 homolog (S. pombe)
, cell cycle checkpoint protein RAD17-like
, cell cycle checkpoint protein RAD17
, Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins
, RAD17 homolog
, Cell cycle checkpoint protein RAD17
, RAD1 homolog
, RF-C activator 1 homolog
, RF-C/activator 1 homolog
, Rad17-like protein
, cell cycle checkpoint protein (RAD17)