RAD17 Homolog (S. Pombe) Protéines (RAD17)

The protein encoded by RAD17 is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. De plus, nous expédions RAD17 Homolog (S. Pombe) Anticorps (193) et RAD17 Homolog (S. Pombe) Kits (4) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
RAD17 5884 O75943
RAD17 19356 Q6NXW6
Rat RAD17 RAD17 310034  
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Top RAD17 Homolog (S. Pombe) Protéines sur anticorps-enligne.fr

Showing 3 out of 4 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,797.11
Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,797.11
Détails
Wheat germ Humain GST tag 2 μg Connectez-vous pour afficher 11 to 12 Days
$338.33
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RAD17 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour RAD17 Homolog (S. Pombe) (RAD17) partenaires d'interaction

Arabidopsis thaliana RAD17 Homolog (S. Pombe) (RAD17) interaction partners

  1. a mutant Rad17 pathway is associated with a general deregulation of DNA repair, which seems to be correlated with a deficiency in non-homologous double strand break repair.

Human RAD17 Homolog (S. Pombe) (RAD17) interaction partners

  1. The Rad17 C-terminal tail is a molecular switch that regulates the 9-1-1 interaction and the ATR pathway.

  2. These data indicate that the interaction with the 9-1-1 complex is not required for Rad17 protein to be an efficient substrate for the UV-induced phosphorylation. Our data also raise the possibility that the 9-1-1 complex plays a negative regulatory role in the Rad17 phosphorylation. We also show that the nucleotide-binding activity of Rad17 is required for its nuclear localization.

  3. In a Japanese population, the variant allele of hRAD17 is significantly associated with a decreased risk of Colorectal Cancer among light smokers and rectal cancer patients and with an increased risk of Colorectal Cancer among heavy smokers.

  4. Authors show that BRCA1 and RAD17 genes, whose derived proteins play a pivotal role in DNA damage repair, are transcriptional targets of gain-of-function mutant p53 (Montrer TP53 Protéines) proteins.

  5. USP20 (Montrer USP20 Protéines) and Rad17 interact, and that this interaction is enhanced by UV exposure. We show that USP20 (Montrer USP20 Protéines) regulation of Rad17 is at the protein level in a proteasome-dependent manner. USP20 (Montrer USP20 Protéines) depletion results in poor activation of Chk1 (Montrer CHEK1 Protéines) protein by phosphorylation

  6. These data suggest that v-Src (Montrer SRC Protéines) attenuates ATR (Montrer ANTXR1 Protéines)-Chk1 (Montrer CHEK1 Protéines) signaling through the inhibition of Rad17-Rad9 (Montrer RAD9A Protéines) interaction.

  7. Rad17 is phosphorylated by ATM (Montrer ATM Protéines) at Thr622 resulting in a direct interaction of Rad17 with NBS1 (Montrer NBN Protéines), facilitating recruitment of MRE11 (Montrer MRE11A Protéines), RAD50 (Montrer RAD50 Protéines) and ATM (Montrer ATM Protéines) to the DNA double-strand breaks.

  8. Our data suggest RAD17 as a novel target protein for gemcitabine combination therapy supplementing or complementing inhibition of CHK1 (Montrer CHEK1 Protéines).

  9. Knockdown of Rad17 with two independent siRNAs significantly reduced Chk1 (Montrer CHEK1 Protéines) phosphorylation and substantial RPA32 (Montrer RPA2 Protéines) Ser33 phosphorylation.

  10. Data indicate that regulation of Rad17 turnover is through the Cdh1 (Montrer CDH1 Protéines)/anaphase-promoting complex pathway in breast cancer cells.

Mouse (Murine) RAD17 Homolog (S. Pombe) (RAD17) interaction partners

  1. targeted deletion of an N-terminal part of mRad17, the mouse homolog of the Schizosaccharomyces pombe Rad17 checkpoint clamp-loader component, resulted in embryonic lethality during early/mid-gestation

Profil protéine RAD17 Homolog (S. Pombe) (RAD17)

Profil protéine

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.

Gene names and symbols associated with RAD17

  • RAD17 checkpoint clamp loader component (RAD17)
  • RAD17 checkpoint clamp loader component (rad17)
  • Rad17p (RAD17)
  • RADIATION SENSITIVE 17 (ATRAD17)
  • RAD17 checkpoint clamp loader component (Rad17)
  • 9430035O09Rik Protéine
  • CCYC Protéine
  • HRAD17 Protéine
  • K2A18.21 Protéine
  • K2A18_21 Protéine
  • MmRad24 Protéine
  • R24L Protéine
  • RAD17 Protéine
  • RAD17SP Protéine
  • RAD24 Protéine
  • RADIATION SENSITIVE 17 Protéine
  • zgc:91969 Protéine

Protein level used designations for RAD17

RAD17 homolog (S. pombe) , cell cycle checkpoint protein RAD17-like , cell cycle checkpoint protein RAD17 , Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins , Rad17p , RAD17 homolog , Cell cycle checkpoint protein RAD17 , RAD1 homolog , RF-C activator 1 homolog , RF-C/activator 1 homolog , Rad17-like protein , cell cycle checkpoint protein (RAD17)

GENE ID SPECIES
100081629 Ornithorhynchus anatinus
100339735 Oryctolagus cuniculus
100385537 Callithrix jacchus
100464145 Ailuropoda melanoleuca
436934 Danio rerio
854550 Saccharomyces cerevisiae S288c
100190842 Pongo abelii
836745 Arabidopsis thaliana
5884 Homo sapiens
19356 Mus musculus
478088 Canis lupus familiaris
513600 Bos taurus
310034 Rattus norvegicus
100065769 Equus caballus
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