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This intronless gene belongs to a family of RAS-related genes. De plus, nous expédions RAP2B Protéines (8) et et beaucoup plus de produits pour cette protéine.
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Rap2B was overexpressed in cervical cancer tissues and cell lines and knockdown of Rap2B inhibited cervical cancer cell proliferation, migration, and invasion in vitro and suppressed cervical cancer cell growth and metastasis in vivo
these results revealed that Rap2B promotes renal cell carcinoma (Montrer MOK Anticorps) angiogenesis via phosphoinositide 3-kinase/AKT (Montrer AKT1 Anticorps)/vascular endothelial growth factor (Montrer VEGF Anticorps) signaling pathway, which suggests that Rap2B is a novel therapeutic target for renal cell carcinoma (Montrer MOK Anticorps) anti-angiogenesis therapy.
our results suggested that Rap2b may be a potential therapeutic target for lung cancer.
knockdown of Rap2B inhibits the proliferation and invasion in HCC (Montrer FAM126A Anticorps) cells. These findings reveal that Rap2B plays an important role in the regulation of HCC (Montrer FAM126A Anticorps) progression.
miR (Montrer MLXIP Anticorps)-194 is inversely correlated with RAP2B.
Western blot analysis uncovered that elevated Rap2B leads to increased phosphorylation levels of FAK (Montrer PTK2 Anticorps), suggesting that FAK (Montrer PTK2 Anticorps)-dependent pathway might be responsible for the effect of Rap2B on PCa (Montrer FLVCR1 Anticorps) cells migration and invasion.
Expression and DNA methylation (Montrer HELLS Anticorps) status of the Rap2B gene in human bronchial epithelial cells treated by cigarette smoke condensate
Our collective findings provide preliminary evidence that miR (Montrer MLXIP Anticorps)-342-3p acts as a tumor suppressor in small cell lung cancer through repression of RAP2B.
Rap2B itself is not necessary for p53 (Montrer TP53 Anticorps)-dependent cell cycle arrest.
Data indicate that rap (Montrer LRPAP1 Anticorps) GTP-binding protein (Montrer HCAR3 Anticorps) Rap2B expression is significantly increased in suprarenal epithelioma and Rap2B can promote the cell migration and invasion abilities, suggesting a target for the treatment of suprarenal epithelioma.
Taken together, these findings shed light on Rap2B as a therapeutic target for breast cancer.
the putative Rap2 (Montrer RAP2A Anticorps) binding site of the RPIPx (Montrer RUFY3 Anticorps) RUN domain interacts with the extended segment in a segment-swapping manner
This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated.
RAP2B, member of RAS oncogene family
, ras-related protein Rap-2b
, ras-dva small GTPase
, ras-like small GTPase
, small GTP binding protein