SMAD Specific E3 Ubiquitin Protein Ligase 2 Protéines (SMURF2)

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. De plus, nous expédions SMURF2 Anticorps (85) et SMURF2 Kits (6) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
SMURF2 64750 Q9HAU4
SMURF2 66313 A2A5Z6
Rat SMURF2 SMURF2 303614  
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Showing 3 out of 3 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
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Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
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HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher 11 Days
$814.00
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SMURF2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) partenaires d'interaction

Rhesus Monkey SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) interaction partners

  1. results provide the evidence that Smurf2 may play specific roles in glandular secretion, trophoblastic cell invasion, and placentation through mediating the expression of the related proteins of TGF-beta signaling pathway during early pregnancy

Human SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) interaction partners

  1. Nedd8 binding to Smurf plays important roles in the regulation of cell migration and the BMP and TGFbeta signaling pathways.

  2. High SMURF2 expression is associated with breast cancer progression.

  3. Smurf2, an E3 ubiquitin ligase, interacts with PDE4B and attenuates liver fibrosis through miR-132 mediated CTGF inhibition.

  4. Low SMURF2 expression is associated with breast cancer organoid invasiveness.

  5. Results identified Smurf2 as an essential regulator of Topo IIalpha, providing novel insights into its control and into the suggested tumor-suppressor functions of Smurf2.

  6. found that phospho-AIMP2 dissociated from the multi-tRNA synthetase complex and translocated to the nucleus, where it bound to Smurf2

  7. Ectopic expression of human Smurf2 driven by the Col2a1 promoter accelerated disc degeneration in Col2a1-Smurf2 transgenic mice, and that higher levels of connective tissue growth factor protein and mRNA were present in Col2a1-Smurf2 transgenic discs, indicate that Smurf2 accelerates disc degeneration via upregulation of connective tissue growth factor.

  8. data suggest for the first time that the choice of binding partners for SMURF2 can sustain or repress TGFbeta signaling, and RNF11 may promote TGFbeta-induced cell migration.

  9. Neddylation of Smurf1 activates its ubiquitin ligase activity and Smurf2 exerts Nedd8 ligase activity. This study provided new clues of Smurf2 activation regulation.

  10. The Smurf2 acts in a sumoylation-regulated manner to suppress TGFbeta-induced Epithelial-mesenchymal transition.

  11. the findings of this study demonstrate that the downregulation of SnoN expression in hRPTECs under high-glucose conditions is mediated by the increased expression of Smurf2 through the TGF-b1/Smad signaling pathway.

  12. SMURF2 is a critical target of USP15 in the TGF-beta signaling pathway.

  13. Data show that miR15b mediates SMURF2 expression in pancreatic cancer and suggest miR15b as an oncogene by promoting epithelial-mesenchymal transition and SMURF2 as a tumor suppressor gene which expression is inhibited by miR15b in pancreatic cancer.

  14. Methylation by PRMT1 may regulate Smurf2 stability and control TGF-beta signaling.

  15. Studies on Smurf2 and Nedd4 show that the C2 domain has the potential to regulate E3 activity by maintaining the HECT domain in a low-activity state where its ability for transthiolation and noncovalent Ubiquitin binding are impaired.

  16. Results suggest that elevated transcription and expression levels of ubiquitin ligase E3s WWP1, Smurf1 and Smurf2 genes may be the mechanisms of occurrence, development and metastasis of prostate cancer.

  17. miR-424 regulates the myofibroblast differentiation during epithelial-to-mesenchymal transition by potentiating the TGF-beta signaling pathway, likely through Smurf2.

  18. The SMURF2:UBCH5 complex is critical in maintaining KRAS protein stability.

  19. These results suggest a novel regulatory mechanism for YY1 function by Smurf2.

  20. Provide evidence of posttranscriptional downregulation of Smurf2 in triple-negative breast cancers, and demonstrate that the loss of RB function is involved in microRNA-mediated interference with Smurf2 translation.

Mouse (Murine) SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) interaction partners

  1. Data suggest that Smad-specific E3 ubiquitin ligase 2 (SMURF2)-mediated SMAD3 protein (SMAD3) monoubiquitination interferes with the formation of a SMAD3-vitamin D receptor (VDR) complex.

  2. Results identified Smurf2 as an essential regulator of Topo IIalpha, providing novel insights into its control and into the suggested tumor-suppressor functions of Smurf2.

  3. Young Smurf2-deficient mice develop milder osteoarthritis in knee articular cartilage compared to WT mice after surgical destabilization of the medial meniscus.

  4. TAT fused to WW2/WW3 of Smurf2 could interfere with TGF-beta signaling and reduce ArgI gene expression.

  5. Smurf-mediated endocytosis of Patched1 is required in sonic hedgehog signal reception

  6. Data indicate that TNF receptor associated factor 4 (TRAF4) recruited the E3-ligase SMURF2, to degrade the IL-25R-inhibitory molecule DAZ associated protein 2 (DAZAP2).

  7. Expression of Smurf2 was increased with age and in response to regenerative stress during serial transplantation, our findings suggest that Smurf2 plays an important role in regulating HSC self-renewal and aging.

  8. Akt regulates osteoblast differentiation by enhancing the protein stability and transcriptional activity of Runx2 through regulation of degradation of Smurf2.

  9. that Smurf2 is an important nonredundant negative regulator of virus-triggered type I IFN signaling by targeting VISA for K48-linked ubiquitination and degradation.

  10. Smurf2 mediates ubiquitination and degradation of YY1, a key germinal centre transcription factor.

  11. Smurf2 deficiency increased the susceptibility of mice to spontaneous tumorigenesis, most notably B-cell lymphoma

  12. T cell-specific DeltaE2Smurf2 degrades wild-type Smurf2 and controls intestinal tumor growth in mice by up-regulating TGF-beta receptor type II, reducing proliferation and production of proinflammatory cytokines.

  13. Smurf2 induces multiple mono-ubiquitination of Smad3 in vivo. Phosphorylation of T179, immediately upstream of the Smad3 PY motif, enhances Smurf2 and Smad3 interaction and Smad3 ubiquitination.

  14. Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts.

  15. AIMP1 negatively regulates TGF-beta signaling via stabilization of Smurf2.

  16. Smurf2-transgenic mice spontaneously develop an osteoarthritis-like phenotype that correlates with decreased TGFbeta signaling and increased pSmad3 degradation

  17. Inhibition of PI3K or mTOR reduced the level of Rap1B, which acts downstream of Rheb and mTOR. The ubiquitin E3 ligase Smurf2 mediates the restriction of Rap1B by initiating its degradation.

  18. Mice mutant for Smurf1 and Smurf2 display planar cell polarity defects in the cochlea and convergence and extension movements defects that include a failure to close the neural tube.

  19. E3 ubiquitin-protein ligase constitutive photomorphogenesis protein 1 is needed for COP1 for degradation via the ubiquitin-proteasome pathway.

Xenopus laevis SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) interaction partners

  1. Data demonstrate that Smurf1 and Smurf2 have overlapping and distinct functionalities during early frog embryogenesis; collectively, they regulate ectodermal and mesodermal induction and patterning to ensure normal development of Xenopus embryos.

Profil protéine SMURF2

Profil protéine

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level (By similarity).

Gene names and symbols associated with SMURF2

  • SMAD specific E3 ubiquitin protein ligase 2 (SMURF2)
  • SMAD specific E3 ubiquitin protein ligase 2 (smurf2)
  • SMAD specific E3 ubiquitin protein ligase 2 (Smurf2)
  • SMAD specific E3 ubiquitin protein ligase 2 S homeolog (smurf2.S)
  • 2810411E22Rik Protéine
  • AI558114 Protéine
  • AI649275 Protéine
  • RGD1310067 Protéine
  • SMURF2 Protéine
  • wu:fb82a11 Protéine
  • wu:fc41c02 Protéine

Protein level used designations for SMURF2

SMAD specific E3 ubiquitin protein ligase 2 , E3 ubiquitin-protein ligase SMURF2-like , e3 ubiquitin-protein ligase SMURF2-like , E3 ubiquitin ligase SMURF2 , E3 ubiquitin-protein ligase SMURF2 , SMAD ubiquitination regulatory factor 2 , SMAD-specific E3 ubiquitin-protein ligase 2 , hSMURF2 , E3 ubiquitin ligase Smurf2

GENE ID SPECIES
100064082 Equus caballus
100230714 Taeniopygia guttata
454761 Pan troglodytes
480470 Canis lupus familiaris
717902 Macaca mulatta
100038194 Xenopus (Silurana) tropicalis
100358121 Oryctolagus cuniculus
100374187 Saccoglossus kowalevskii
100386392 Callithrix jacchus
100459970 Pongo abelii
100473715 Ailuropoda melanoleuca
100603634 Nomascus leucogenys
64750 Homo sapiens
66313 Mus musculus
303614 Rattus norvegicus
427809 Gallus gallus
540826 Bos taurus
398372 Xenopus laevis
563633 Danio rerio
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