SMAD Specific E3 Ubiquitin Protein Ligase 2 Protéines (SMURF2)

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. De plus, nous expédions SMURF2 Anticorps (82) et SMURF2 Kits (6) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
SMURF2 64750 Q9HAU4
SMURF2 66313 A2A5Z6
Rat SMURF2 SMURF2 303614  
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Showing 3 out of 3 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$814.00
Détails

SMURF2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) partenaires d'interaction

Rhesus Monkey SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) interaction partners

  1. results provide the evidence that Smurf2 may play specific roles in glandular secretion, trophoblastic cell invasion, and placentation through mediating the expression of the related proteins of TGF-beta (Montrer TGFB1 Protéines) signaling pathway during early pregnancy

Human SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) interaction partners

  1. Nedd8 (Montrer NEDD8 Protéines) binding to Smurf plays important roles in the regulation of cell migration and the BMP and TGFbeta (Montrer TGFB1 Protéines) signaling pathways.

  2. High SMURF2 expression is associated with breast cancer progression.

  3. Smurf2, an E3 ubiquitin ligase (Montrer MUL1 Protéines), interacts with PDE4B (Montrer PDE4B Protéines) and attenuates liver fibrosis through miR (Montrer MLXIP Protéines)-132 mediated CTGF (Montrer CTGF Protéines) inhibition.

  4. Low SMURF2 expression is associated with breast cancer organoid invasiveness.

  5. Results identified Smurf2 as an essential regulator of Topo IIalpha, providing novel insights into its control and into the suggested tumor-suppressor functions of Smurf2.

  6. found that phospho-AIMP2 (Montrer AIMP2 Protéines) dissociated from the multi-tRNA synthetase complex and translocated to the nucleus, where it bound to Smurf2

  7. Ectopic expression of human Smurf2 driven by the Col2a1 (Montrer COL2A1 Protéines) promoter accelerated disc degeneration in Col2a1 (Montrer COL2A1 Protéines)-Smurf2 transgenic mice, and that higher levels of connective tissue growth factor (Montrer CTGF Protéines) protein and mRNA were present in Col2a1 (Montrer COL2A1 Protéines)-Smurf2 transgenic discs, indicate that Smurf2 accelerates disc degeneration via upregulation of connective tissue growth factor (Montrer CTGF Protéines).

  8. data suggest for the first time that the choice of binding partners for SMURF2 can sustain or repress TGFbeta (Montrer TGFB1 Protéines) signaling, and RNF11 (Montrer RNF11 Protéines) may promote TGFbeta (Montrer TGFB1 Protéines)-induced cell migration.

  9. Neddylation of Smurf1 (Montrer SMURF1 Protéines) activates its ubiquitin ligase activity and Smurf2 exerts Nedd8 (Montrer NEDD8 Protéines) ligase activity. This study provided new clues of Smurf2 activation regulation.

  10. The Smurf2 acts in a sumoylation-regulated manner to suppress TGFbeta (Montrer TGFB1 Protéines)-induced Epithelial-mesenchymal transition.

Mouse (Murine) SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) interaction partners

  1. Results identified Smurf2 as an essential regulator of Topo IIalpha, providing novel insights into its control and into the suggested tumor-suppressor functions of Smurf2.

  2. Young Smurf2-deficient mice develop milder osteoarthritis in knee articular cartilage compared to WT mice after surgical destabilization of the medial meniscus.

  3. TAT (Montrer TAT Protéines) fused to WW2/WW3 of Smurf2 could interfere with TGF-beta (Montrer TGFB1 Protéines) signaling and reduce ArgI gene expression.

  4. Smurf-mediated endocytosis of Patched1 (Montrer PTCH1 Protéines) is required in sonic hedgehog (Montrer SHH Protéines) signal reception

  5. Data indicate that TNF receptor associated factor 4 (TRAF4 (Montrer TRAF4 Protéines)) recruited the E3-ligase SMURF2, to degrade the IL-25R-inhibitory molecule DAZ associated protein 2 (DAZAP2 (Montrer DAZAP2 Protéines)).

  6. Expression of Smurf2 was increased with age and in response to regenerative stress during serial transplantation, our findings suggest that Smurf2 plays an important role in regulating HSC (Montrer FUT1 Protéines) self-renewal and aging.

  7. Akt (Montrer AKT1 Protéines) regulates osteoblast differentiation by enhancing the protein stability and transcriptional activity of Runx2 (Montrer RUNX2 Protéines) through regulation of degradation of Smurf2.

  8. that Smurf2 is an important nonredundant negative regulator of virus-triggered type I IFN signaling by targeting VISA (Montrer MAVS Protéines) for K48-linked ubiquitination and degradation.

  9. Smurf2 mediates ubiquitination and degradation of YY1 (Montrer YY1 Protéines), a key germinal centre transcription factor.

  10. Smurf2 deficiency increased the susceptibility of mice to spontaneous tumorigenesis, most notably B-cell lymphoma

Xenopus laevis SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) interaction partners

  1. Data demonstrate that Smurf1 (Montrer SMURF1 Protéines) and Smurf2 have overlapping and distinct functionalities during early frog embryogenesis; collectively, they regulate ectodermal and mesodermal induction and patterning to ensure normal development of Xenopus embryos.

Profil protéine SMURF2

Profil protéine

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level (By similarity).

Gene names and symbols associated with SMURF2

  • SMAD specific E3 ubiquitin protein ligase 2 (SMURF2)
  • SMAD specific E3 ubiquitin protein ligase 2 (smurf2)
  • SMAD specific E3 ubiquitin protein ligase 2 (Smurf2)
  • SMAD specific E3 ubiquitin protein ligase 2 S homeolog (smurf2.S)
  • 2810411E22Rik Protéine
  • AI558114 Protéine
  • AI649275 Protéine
  • RGD1310067 Protéine
  • SMURF2 Protéine
  • wu:fb82a11 Protéine
  • wu:fc41c02 Protéine

Protein level used designations for SMURF2

SMAD specific E3 ubiquitin protein ligase 2 , E3 ubiquitin-protein ligase SMURF2-like , e3 ubiquitin-protein ligase SMURF2-like , E3 ubiquitin ligase SMURF2 , E3 ubiquitin-protein ligase SMURF2 , SMAD ubiquitination regulatory factor 2 , SMAD-specific E3 ubiquitin-protein ligase 2 , hSMURF2 , E3 ubiquitin ligase Smurf2

GENE ID SPECIES
100064082 Equus caballus
100230714 Taeniopygia guttata
454761 Pan troglodytes
480470 Canis lupus familiaris
717902 Macaca mulatta
100038194 Xenopus (Silurana) tropicalis
100358121 Oryctolagus cuniculus
100374187 Saccoglossus kowalevskii
100386392 Callithrix jacchus
100459970 Pongo abelii
100473715 Ailuropoda melanoleuca
100603634 Nomascus leucogenys
64750 Homo sapiens
66313 Mus musculus
303614 Rattus norvegicus
427809 Gallus gallus
540826 Bos taurus
398372 Xenopus laevis
563633 Danio rerio
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