Use your antibodies-online credentials, if available.
Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. De plus, nous expédions SMURF2 Anticorps (82) et SMURF2 Kits (6) et beaucoup plus de produits pour cette protéine.
Showing 3 out of 3 products:
results provide the evidence that Smurf2 may play specific roles in glandular secretion, trophoblastic cell invasion, and placentation through mediating the expression of the related proteins of TGF-beta (Montrer TGFB1 Protéines) signaling pathway during early pregnancy
Nedd8 (Montrer NEDD8 Protéines) binding to Smurf plays important roles in the regulation of cell migration and the BMP and TGFbeta (Montrer TGFB1 Protéines) signaling pathways.
High SMURF2 expression is associated with breast cancer progression.
Smurf2, an E3 ubiquitin ligase (Montrer MUL1 Protéines), interacts with PDE4B (Montrer PDE4B Protéines) and attenuates liver fibrosis through miR (Montrer MLXIP Protéines)-132 mediated CTGF (Montrer CTGF Protéines) inhibition.
Low SMURF2 expression is associated with breast cancer organoid invasiveness.
Results identified Smurf2 as an essential regulator of Topo IIalpha, providing novel insights into its control and into the suggested tumor-suppressor functions of Smurf2.
found that phospho-AIMP2 (Montrer AIMP2 Protéines) dissociated from the multi-tRNA synthetase complex and translocated to the nucleus, where it bound to Smurf2
Ectopic expression of human Smurf2 driven by the Col2a1 (Montrer COL2A1 Protéines) promoter accelerated disc degeneration in Col2a1 (Montrer COL2A1 Protéines)-Smurf2 transgenic mice, and that higher levels of connective tissue growth factor (Montrer CTGF Protéines) protein and mRNA were present in Col2a1 (Montrer COL2A1 Protéines)-Smurf2 transgenic discs, indicate that Smurf2 accelerates disc degeneration via upregulation of connective tissue growth factor (Montrer CTGF Protéines).
data suggest for the first time that the choice of binding partners for SMURF2 can sustain or repress TGFbeta (Montrer TGFB1 Protéines) signaling, and RNF11 (Montrer RNF11 Protéines) may promote TGFbeta (Montrer TGFB1 Protéines)-induced cell migration.
Neddylation of Smurf1 (Montrer SMURF1 Protéines) activates its ubiquitin ligase activity and Smurf2 exerts Nedd8 (Montrer NEDD8 Protéines) ligase activity. This study provided new clues of Smurf2 activation regulation.
The Smurf2 acts in a sumoylation-regulated manner to suppress TGFbeta (Montrer TGFB1 Protéines)-induced Epithelial-mesenchymal transition.
Young Smurf2-deficient mice develop milder osteoarthritis in knee articular cartilage compared to WT mice after surgical destabilization of the medial meniscus.
TAT (Montrer TAT Protéines) fused to WW2/WW3 of Smurf2 could interfere with TGF-beta (Montrer TGFB1 Protéines) signaling and reduce ArgI gene expression.
Smurf-mediated endocytosis of Patched1 (Montrer PTCH1 Protéines) is required in sonic hedgehog (Montrer SHH Protéines) signal reception
Data indicate that TNF receptor associated factor 4 (TRAF4 (Montrer TRAF4 Protéines)) recruited the E3-ligase SMURF2, to degrade the IL-25R-inhibitory molecule DAZ associated protein 2 (DAZAP2 (Montrer DAZAP2 Protéines)).
Expression of Smurf2 was increased with age and in response to regenerative stress during serial transplantation, our findings suggest that Smurf2 plays an important role in regulating HSC (Montrer FUT1 Protéines) self-renewal and aging.
Akt (Montrer AKT1 Protéines) regulates osteoblast differentiation by enhancing the protein stability and transcriptional activity of Runx2 (Montrer RUNX2 Protéines) through regulation of degradation of Smurf2.
that Smurf2 is an important nonredundant negative regulator of virus-triggered type I IFN signaling by targeting VISA (Montrer MAVS Protéines) for K48-linked ubiquitination and degradation.
Smurf2 mediates ubiquitination and degradation of YY1 (Montrer YY1 Protéines), a key germinal centre transcription factor.
Smurf2 deficiency increased the susceptibility of mice to spontaneous tumorigenesis, most notably B-cell lymphoma
Data demonstrate that Smurf1 (Montrer SMURF1 Protéines) and Smurf2 have overlapping and distinct functionalities during early frog embryogenesis; collectively, they regulate ectodermal and mesodermal induction and patterning to ensure normal development of Xenopus embryos.
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level (By similarity).
SMAD specific E3 ubiquitin protein ligase 2
, E3 ubiquitin-protein ligase SMURF2-like
, e3 ubiquitin-protein ligase SMURF2-like
, E3 ubiquitin ligase SMURF2
, E3 ubiquitin-protein ligase SMURF2
, SMAD ubiquitination regulatory factor 2
, SMAD-specific E3 ubiquitin-protein ligase 2
, E3 ubiquitin ligase Smurf2