Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) Kits ELISA

SIGLEC5 encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. De plus, nous expédions SIGLEC5 Anticorps (119) et SIGLEC5 Protéines (18) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
SIGLEC5 8778 O15389
Anti-Rat SIGLEC5 SIGLEC5 292843  
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Humain 3 pg/mL 6.9-5000 pg/mL 96 Tests 3 to 4 Days
  96 Tests 21 to 31 Days
Humain 3 pg/mL 6.9 pg/mL - 5000 pg/mL   96 Tests 5 to 8 Days

SIGLEC5 Kits ELISA mieux référencés

  1. Human SIGLEC5 Kit ELISA pour Sandwich ELISA - ABIN625088 : Wu, Ding, Han, Arriens, Wei, Han, Pedroza, Jiang, Anolik, Petri, Sanz, Saxena, Mohan: Antibody-Array-Based Proteomic Screening of Serum Markers in Systemic Lupus Erythematosus: A Discovery Study. dans Journal of proteome research 2016 (PubMed)

Plus Kits ELISA pour SIGLEC5 partenaires d'interaction

Human Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) interaction partners

  1. Plasma Siglec-5 levels are implicated as an early diagnostic marker of CLI in T2DM patients and it may become a target for the prevention or treatment of CLI in diabetes.

  2. PSGL1 and Siglec-5 are in close proximity at the leukocyte surface.SPSGL1 is a ligand for Siglec-5 and interacts with Siglec-5 ectodomain.Siglec-5 plays a role in PSGL1-mediated leukocyte rolling and the inflammatory response in general.

  3. An unbiased screen revealed Hsp70 as a ligand for Siglec-5 and Siglec-14. Hsp70 stimulation through Siglec-5 delivers an anti-inflammatory signal, while stimulation through Siglec-14 is pro-inflammatory.

  4. Data indicate that the Siglec-5/14 genotype influences neutrophil responses to group B Streptococcus.

  5. we found that secretory IgA is taken up by M cells via the Dectin-1 receptor, with the possible involvement of Siglec-5 acting as a co-receptor.

  6. These studies demonstrate the Siglec5 carbohydrate recognition domain alone is sufficient for binding sialylated carbohydrates and provide a foundation for further investigation of Siglec5 structure and function.

  7. Siglec-5 expression protects T cells from HIV-1- and apoptosis-induced cell death and contributes to the different outcomes of HIV-1 infection in humans and chimpanzees.

  8. Human Siglec-5 inhibitory receptor and immunoglobulin A (IgA) have separate binding sites in streptococcal beta protein.

  9. Siglec-5 expression correlates with lack of proliferation in a subset of human cells, and is upregulated by activation of chimpanzee but not human lymphocytes.

  10. expression of Siglec-5 on cells of the myelomonocytic lineage and alteration of its expression by inflammatory stimuli suggest a role for this protein in cell/cell interactions following microbial exposure.

  11. Siglec-5 can be classified as an inhibitory receptor with the potential to mediate SHP-1 and/or SHP-2-dependent signaling in the absence of tyrosine phosphorylation.

  12. Siglecs-5 did not interact with sulfate derivatives of LacNAc and sulfated oligosaccharides containing sialic acid.

  13. The expression levels of Siglec-5 were high or detectable in bone marrow plasma from AML patients and serum from normal donors.

  14. Siglec-14 and Siglec-5 appear to be the first glycan binding paired receptors. Near-complete sequence identity of the amino-terminal part of human Siglec-14 and Siglec-5 indicates partial gene conversion between SIGLEC14 and SIGLEC5.

  15. Siglec-5 is identified as a receptor for alpha-1-acid glycoprotein (AGP) 1 in human neutrophils.

  16. Structural implications of SIGLEC5-mediated sialoglycan recognition are reported.

  17. Group B Streptococcus beta protein binding to Siglec-5 functions to impair leukocyte phagocytosis, oxidative burst, and extracellular trap production, promoting bacterial survival.

SIGLEC5 profil antigène

Antigen Summary

This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.

Gene names and symbols associated with SIGLEC5

  • sialic acid binding Ig like lectin 5 (SIGLEC5) anticorps
  • sialic acid-binding Ig-like lectin 5 (LOC100597560) anticorps
  • sialic acid binding Ig-like lectin 5 (Siglec5) anticorps
  • CD33L2 anticorps
  • CD170 anticorps
  • OB-BP2 anticorps
  • OBBP2 anticorps
  • SIGLEC-5 anticorps

Protein level used designations for SIGLEC5

CD33 antigen-like 2 , OB-binding protein 2 , obesity-binding protein 2 , sialic acid-binding Ig-like lectin 5 , sialic acid-binding immunoglobulin-like lectin 5 , sialic acid binding Ig-like lectin 5

8778 Homo sapiens
100597560 Nomascus leucogenys
292843 Rattus norvegicus
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