anti-Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) Anticorps

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. De plus, nous expédions SIGLEC8 Kits (20) et SIGLEC8 Protéines (7) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
SIGLEC8 27181 Q9NYZ4
SIGLEC8    
SIGLEC8    
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Top anti-SIGLEC8 Anticorps sur anticorps-enligne.fr

Showing 10 out of 76 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Chèvre Inconjugué ELISA, WB ABIN308467 (0.3µg/ml) staining of MOLT4 lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Connectez-vous pour afficher 6 to 7 Days
$429.62
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$390.50
Détails
Humain Chèvre Inconjugué ELISA, WB 100 μg Connectez-vous pour afficher 7 to 9 Days
$610.50
Détails
Humain Lapin Inconjugué IHC (p), WB SIGLEC8 Antibody (N-term) (ABIN658485) western blot analysis in HepG2 cell line lysates (35 µg/lane). This demonstrates the SIGLEC8 antibody detected the SIGLEC8 protein (arrow). 400 μL Connectez-vous pour afficher 10 to 11 Days
$335.50
Détails
Humain Lapin Inconjugué IHC (p), WB The anti-Siglec8 C-term Pab (ABIN388420) is used in Western blot to detect Siglec8 in mouse liver tissue lysate (lnae 1) and in HL60 cell lysate (lane 2). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Connectez-vous pour afficher 10 to 11 Days
$335.50
Détails
Humain Souris PE FACS Detection of Siglec-8 in Human Blood Granulocytes by Flow Cytometry. Human peripheral blood granulocytes were stained with Rat Anti-Human CCR3 APC-conjugated Monoclonal Antibody. 100 Tests Connectez-vous pour afficher 8 to 9 Days
$369.15
Détails
Humain Souris Alexa Fluor 700 FACS Detection of Siglec-8 in Human Blood Granulocytes by Flow Cytometry. Human peripheral blood granulocytes were stained with Rat Anti-Human CCR3 PE-conjugated Monoclonal Antibody. 100 Tests Connectez-vous pour afficher 8 to 9 Days
$387.55
Détails
Humain Souris Alexa Fluor 488 FACS Detection of Siglec-8 in Human Blood Granulocytes by Flow Cytometry. Human peripheral blood granulocytes were stained with Rat Anti-Human CCR3 APC-conjugated Monoclonal Antibody. 100 Tests Connectez-vous pour afficher 8 to 9 Days
$393.30
Détails
Humain Souris APC FACS Detection of Siglec-8 in Human Blood Granulocytes by Flow Cytometry. Human peripheral blood granulocytes were stained with Rat Anti-Human CCR3 PE-conjugated Monoclonal Antibody. 100 Tests Connectez-vous pour afficher 8 to 9 Days
$416.30
Détails
Humain Souris PerCP FACS Detection of Siglec-8 in Human Blood Granulocytes by Flow Cytometry. Human peripheral blood granulocytes were stained with Rat Anti-Human CCR3 Fluorescein-conjugated Monoclonal Antibody. 100 Tests Connectez-vous pour afficher 8 to 9 Days
$422.05
Détails

anti-SIGLEC8 Anticorps mieux référencés

  1. Human Polyclonal SIGLEC8 Primary Antibody pour ELISA, WB - ABIN449557 : Nutku, Aizawa, Hudson, Bochner: Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis. dans Blood 2003 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal SIGLEC8 Primary Antibody pour ELISA, WB - ABIN565353 : von Gunten, Vogel, Schaub, Stadler, Miescher, Crocker, Simon: Intravenous immunoglobulin preparations contain anti-Siglec-8 autoantibodies. dans The Journal of allergy and clinical immunology 2007 (PubMed)

Plus d’anticorps contre SIGLEC8 partenaires d’interaction

Human Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) interaction partners

  1. In differentiating ,eosinophils, SIGLEC-8 messenger RNA and protein were markedly down-regulated in parallel with OLIG2 (Montrer OLIG2 Anticorps) by an OLIG2 (Montrer OLIG2 Anticorps) small interfering RNA or a short hairpin RNA. An E-box in the first intron was found to stimulate SIGLEC-8 gene transcription and to bind OLIG2 (Montrer OLIG2 Anticorps).

  2. miR (Montrer MLXIP Anticorps)-215 acts in concert with the host gene IARS2 to affect neuron migration and proliferation through the target gene SIGLEC-8.

  3. Our study suggested that intratumoral Siglec-8 expression was an independent prognostic factor for overall survival of patients with gastric cancer

  4. Ligands for Siglec-8 and Siglec-9 may regulate the function of eosinophils, mast cells, neutrophils, and other cells in sinus mucosa.

  5. Inflammation results in up-regulation of immuneinhibitory Siglec-8 and Siglec-9 sialoglycan ligands on human airways.

  6. Siglec-8 expression is sensitive to tiotropium and formoterol, indicating that it may be involved in COPD (Montrer ARCN1 Anticorps) pathogenesis and may influence COPD (Montrer ARCN1 Anticorps) phenotyping

  7. In activated eosinophils ligation of Siglec-8 leads to ROS (Montrer ROS1 Anticorps)-dependent enhancement of IL-5 (Montrer IL5 Anticorps)-induced ERK (Montrer EPHB2 Anticorps) phosphorylation, which results in a novel mode of biochemically regulated eosinophil cell death.

  8. Engagement of Siglec-8 on blood eosinophils results in caspase (Montrer CASP3 Anticorps)- and mitochondria-dependent apoptosis.

  9. Eosinophils primed by IL-33 (Montrer IL33 Anticorps) and/or IL-5 (Montrer IL5 Anticorps) in vivo would be expected to display enhanced susceptibility to undergoing Siglec-8-induced apoptosis.

  10. The Siglec-8 gene may be a susceptibility locus for asthma.

SIGLEC8 profil antigène

Profil protéine

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM\\\\; MIM 603492) that mediates an association with SLAM-associated protein (SAP\\\\; MIM 300490) (summarized by Foussias et al., 2000

Gene names and symbols associated with SIGLEC8

  • sialic acid binding Ig like lectin 8 (SIGLEC8) anticorps
  • sialic acid-binding Ig-like lectin 8 (LOC506364) anticorps
  • SAF2 anticorps
  • SIGLEC-8 anticorps
  • SIGLEC8 anticorps
  • SIGLEC8L anticorps

Protein level used designations for SIGLEC8

CDw329 , SAF-2 , sialic acid-binding Ig-like lectin 8 , sialoadhesin family member 2 , sialic acid binding Ig-like lectin 8

GENE ID SPECIES
27181 Homo sapiens
456249 Pan troglodytes
506364 Bos taurus
100595640 Nomascus leucogenys
Fournisseurs de qualité sélectionnés pour anti-SIGLEC8 (SIGLEC8) Anticorps
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