anti-Sirtuin 5 (SIRT5) Anticorps

SIRT5 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. De plus, nous expédions Sirtuin 5 Protéines (20) et Sirtuin 5 Kits (19) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
SIRT5 23408 Q9NXA8
SIRT5 68346 Q8K2C6
SIRT5 306840 Q68FX9
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Top anti-Sirtuin 5 Anticorps sur anticorps-enligne.fr

Showing 10 out of 194 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB WB Suggested Anti-SIRT5 Antibody Titration:  0.2-1 ug/ml  Positive Control:  HepG2 cell lysate Human Spermatophore 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-SIRT5 Antibody Titration:  5.0ug/ml  ELISA Titer:  1:62500  Positive Control:  Human heart Lanes:   Lane1: Untransfected HEK293T lysate Lane2: mSIRT5-FLAG transfected HEK293T lysate  Primary Antibody Dilution:   1:200  Secondary Antibody:   ProteinA-HRP  Secondary Antibody Dilution:   1:5000  Gene Name:   SIRT5  Submitted by:   Anonymous  There is BioGPS gene expression data showing that SIRT5 is expressed in HEK293T 100 μL Connectez-vous pour afficher 2 to 3 Days
$229.00
Détails
Humain Lapin Inconjugué WB 100 μg Connectez-vous pour afficher 2 to 3 Days
$245.00
Détails
Humain Lapin Inconjugué IHC, IHC (p), WB Immunohistochemistry-Paraffin: SIRT5 Antibody [NBP1-86013] - Staining of human adrenal gland shows strong granular staining of the cytioplasm in cortical cells. Western Blot: SIRT5 Antibody [NBP1-86013] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY415885) 0.1 mL Connectez-vous pour afficher 10 to 13 Days
$491.63
Détails
Humain Souris Inconjugué FACS, WB 100 μL Connectez-vous pour afficher 7 to 9 Days
$507.83
Détails
Humain Souris Inconjugué FACS, IF, IHC, IHC (p), WB 100 μL Connectez-vous pour afficher 7 to 9 Days
$507.83
Détails
Humain Souris Inconjugué FACS, IF, IHC, IHC (p), WB 100 μL Connectez-vous pour afficher 7 to 9 Days
$507.83
Détails
Humain Souris Inconjugué FACS, IF, WB 100 μL Connectez-vous pour afficher 7 to 9 Days
$522.50
Détails
Boeuf (Vache) Lapin Inconjugué IHC, IHC (p), WB Human Small Intestine, Muscularis Mucosa: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Vessels: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Connectez-vous pour afficher 11 to 14 Days
$727.83
Détails

SIRT5 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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anti-Sirtuin 5 Anticorps mieux référencés

  1. Human Polyclonal SIRT5 Primary Antibody pour IHC (fro), IF (p) - ABIN1387080 : Takumida, Takumida, Anniko: Localization of sirtuins in the mouse inner ear. dans Acta oto-laryngologica 2014 (PubMed)

  2. Human Polyclonal SIRT5 Primary Antibody pour IHC (p), WB - ABIN390180 : Wang, Yi, Li, Cai, He, Ni, Zhou, Cheng, Jin, Fan, Qiu: Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection. dans BMC cancer 2014 (PubMed)

  3. Human Polyclonal SIRT5 Primary Antibody pour WB - ABIN252349 : Alhazzazi, Kamarajan, Joo, Huang, Verdin, DSilva, Kapila: Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. dans Cancer 2011 (PubMed)

  4. Cow (Bovine) Polyclonal SIRT5 Primary Antibody pour WB - ABIN2778619 : Mahlknecht, Ho, Letzel, Voelter-Mahlknecht: Assignment of the NAD-dependent deacetylase sirtuin 5 gene (SIRT5) to human chromosome band 6p23 by in situ hybridization. dans Cytogenetic and genome research 2006 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal SIRT5 Primary Antibody pour IHC, IHC (p) - ABIN4353920 : Lv, Liu, Cheng, Yu, Xiong, Hu, Tang, Zeng, Sang: SUN2 exerts tumor suppressor functions by suppressing the Warburg effect in lung cancer. dans Scientific reports 2015 (PubMed)

Plus d’anticorps contre Sirtuin 5 partenaires d’interaction

Human Sirtuin 5 (SIRT5) interaction partners

  1. In this study, we summarize biological functions of SIRT5 reported in normal tissues and in cancer and discuss potential mechanisms whereby SIRT5 may impact tumorigenesis, particularly focusing on its reported roles in metabolic reprogramming. Finally, we review current efforts to target SIRT5 pharmacologically

  2. The roles of the CDK2 (Montrer CDK2 Anticorps)/SIRT5 axis in gastric cancer.

  3. SIRT5 gene has an important regulatory role in liver carcinogenesis, and may function as a novel potential therapeutic target for HCC (Montrer FAM126A Anticorps).

  4. This study showed that SIRT5 supports the anaplerotic entry of glutamine (Montrer GFPT1 Anticorps) into the TCA cycle in malignant phenotypes of CRC (Montrer CALR Anticorps) via activating GLUD1 (Montrer GLUD1 Anticorps).

  5. Results show that SIRT5 binds to, desuccinylates and inhibits PKM2 activity. Increased levels of reactive oxygen species (ROS) decreases succinylation and activity of PKM2 by increasing its binding to SIRT5. Moreover, inhibition of SIRT5 suppresses tumor cell proliferation through desuccinylation of PKM2 K498.

  6. The function of the three mitochondrial sirtuins (SIRT3 (Montrer SIRT3 Anticorps), SIRT4 (Montrer SIRT4 Anticorps), SIRT5) and their role in disease are reviewed.

  7. Our study uncovers a SIRT5-dependent mechanism that regulates cellular NADPH (Montrer NQO1 Anticorps) homeostasis and redox potential by promoting IDH2 (Montrer IDH2 Anticorps) desuccinylation and G6PD (Montrer G6PD Anticorps) deglutarylation.

  8. Results demonstrated presence of endogenous SIRT5 in mitochondria of cultured SH-EP cells, identified down-regulation of cellular oxidative stress by SIRT5 as one of the possible mechanisms mediating the anti-apoptotic effect of SIRT5 in SH-EP cells.

  9. Data (including data from studies using knockout mice) suggest that SIRT5 is targeted to protein complexes on the inner mitochondrial membrane via affinity for cardiolipin to promote respiratory chain function, particularly Complex I and Complex II; SIRT5 expression is observed in inner mitochondrial membrane of periportal hepatocytes.

  10. a side chain-to-side chain cyclic pentapeptide harboring a central N(epsilon)-carboxyethyl-thiocarbamoyl-lysine residue behaved as a strong and selective (versus human SIRT1 (Montrer SIRT1 Anticorps)/2/3/6) inhibitor against human SIRT5-catalyzed deacylation reaction.

Mouse (Murine) Sirtuin 5 (SIRT5) interaction partners

  1. Data indicate that sirtuin 5 (SIRT5) is an important mitochondrial enzyme for protection against metabolic and ischemic stress following protein kinase C epsilon (PKCepsilon (Montrer PRKCE Anticorps)) activation in the brain.

  2. findings reveal a key role for SIRT5 in maintaining cardiac oxidative metabolism under pressure overload to ensure survival

  3. Deletion of Sirt5 in starved mouse embryonic fibroblasts increased levels of mitochondrial dynamics leading to mitochondrial accumulation of the pro-fission Drp1 (Montrer CRMP1 Anticorps) and to mitochondrial fragmentation.

  4. Our study uncovers a SIRT5-dependent mechanism that regulates cellular NADPH (Montrer FDXR Anticorps) homeostasis and redox potential by promoting IDH2 (Montrer IDH2 Anticorps) desuccinylation and G6PD (Montrer G6PD Anticorps) deglutarylation.

  5. Data (including data from studies using knockout mice) suggest that SIRT5 is targeted to protein complexes on the inner mitochondrial membrane via affinity for cardiolipin to promote respiratory chain function, particularly Complex I and Complex II; SIRT5 expression is observed in inner mitochondrial membrane of periportal hepatocytes.

  6. Data show that peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) overexpression significantly increased the expression of sirtuin 3 (SIRT3 (Montrer SIRT3 Anticorps)) and sirtuin 5 (SIRT5).

  7. In the cochlea, the expression of SIRT1 (Montrer SIRT1 Anticorps), 3, and 5 (both mRNA and protein) was decreased in the old mice

  8. These findings establish that regulating heart metabolism and function is a major physiological function of lysine succinylation and SIRT5.

  9. Myocardial ischemic reperfusion injury in Sirt5-/- heart is restored to wild-type levels by pretreatment with dimethyl malonate, a competitive inhibitor of succinate dehydrogenase (SDH (Montrer SDHA Anticorps)), implicating alteration in SDH (Montrer SDS Anticorps) activity as causative of the injury.

  10. SIRT5 has a role in cellular metabolism with a multiple enzymatic activities

Cow (Bovine) Sirtuin 5 (SIRT5) interaction partners

  1. Association analysis of individual SIRT5 SNPs and haplotype combinations reveal that the 4 loci are significantly associated with some body measurement and ultrasound traits in Qinchuan cattle.

Sirtuin 5 (SIRT5) profil antigène

Profil protéine

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants.

Gene names and symbols associated with anti-Sirtuin 5 (SIRT5) Anticorps

  • sirtuin 5 (SIRT5) anticorps
  • sirtuin 5 (Sirt5) anticorps
  • sirtuin 5 (sirt5) anticorps
  • sirtuin 5 L homeolog (sirt5.L) anticorps
  • sirtuin 5 (CC1G_00083) anticorps
  • 0610012J09Rik anticorps
  • 1500032M05Rik anticorps
  • AV001953 anticorps
  • sir2l5 anticorps
  • SIRT5 anticorps
  • sirt5-a anticorps
  • zgc:92288 anticorps

Protein level used designations for anti-Sirtuin 5 (SIRT5) Anticorps

NAD-dependent deacetylase sirtuin-5 , NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial , NAD-dependent protein deacylase sirtuin-5, mitochondrial , SIR2-like protein 5 , regulatory protein SIR2 homolog 5 , silent mating type information regulation 2, S.cerevisiae, homolog 5 , sir2-like 5 , sirtuin type 5 , Regulatory protein SIR2 homolog 5 , NAD-dependent lysine demalonylase and desuccinylase sirtuin-5A, mitochondrial , NAD-dependent protein deacylase sirtuin-5A, mitochondrial , regulatory protein SIR2 homolog 5-a , sirtuin (silent mating type information regulation 2 homolog) 5 , sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) , sirtuin 5 , nad-dependent deacetylase sirtuin-5

GENE ID SPECIES
23408 Homo sapiens
68346 Mus musculus
306840 Rattus norvegicus
420834 Gallus gallus
436878 Danio rerio
478726 Canis lupus familiaris
496346 Xenopus laevis
507347 Bos taurus
700855 Macaca mulatta
747069 Pan troglodytes
6013501 Coprinopsis cinerea okayama7130
100125966 Sus scrofa
100170199 Xenopus (Silurana) tropicalis
100173543 Pongo abelii
100528250 Ictalurus punctatus
100718110 Cavia porcellus
100339154 Oryctolagus cuniculus
100860989 Capra hircus
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