anti-Sirtuin 5 (SIRT5) Anticorps

SIRT5 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. De plus, nous expédions Sirtuin 5 Protéines (20) et Sirtuin 5 Kits (14) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
SIRT5 23408 Q9NXA8
SIRT5 68346 Q8K2C6
SIRT5 306840 Q68FX9
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Top anti-Sirtuin 5 Anticorps sur anticorps-enligne.fr

Showing 10 out of 188 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB 100 μL 2 to 3 Days
$319.00
Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB WB Suggested Anti-SIRT5 Antibody Titration:  0.2-1 ug/ml  Positive Control:  HepG2 cell lysate Human Spermatophore 100 μL 2 to 3 Days
$319.00
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-SIRT5 Antibody Titration:  5.0ug/ml  ELISA Titer:  1:62500  Positive Control:  Human heart Lanes:   Lane1: Untransfected HEK293T lysate Lane2: mSIRT5-FLAG transfected HEK293T lysate  Primary Antibody Dilution:   1:200  Secondary Antibody:   ProteinA-HRP  Secondary Antibody Dilution:   1:5000  Gene Name:   SIRT5  Submitted by:   Anonymous  There is BioGPS gene expression data showing that SIRT5 is expressed in HEK293T 100 μL 2 to 3 Days
$229.00
Détails
Humain Lapin Inconjugué WB 100 μg 2 to 3 Days
$245.00
Détails
Humain Souris Inconjugué FACS, IF, IHC, IHC (p), WB 100 μL 11 to 14 Days
$522.50
Détails
Humain Souris Inconjugué FACS, IF, IHC, IHC (p), WB 100 μL 11 to 14 Days
$522.50
Détails
Humain Souris Inconjugué FACS, WB 100 μL 11 to 14 Days
$522.50
Détails
Humain Souris Inconjugué FACS, IF, WB 100 μL 11 to 14 Days
$522.50
Détails
Boeuf (Vache) Lapin Inconjugué IHC, IHC (p), WB Human Small Intestine, Muscularis Mucosa: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Vessels: Formalin-Fixed, Paraffin-Embedded (FFPE) 100 μL 11 to 14 Days
$727.83
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB 0.4 mL 6 to 8 Days
$484.00
Détails

anti-Sirtuin 5 Anticorps mieux référencés

  1. Human Polyclonal SIRT5 Primary Antibody pour IHC (p), ELISA - ABIN545749 : Frye: Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. dans Biochemical and biophysical research communications 1999 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal SIRT5 Primary Antibody pour WB - ABIN252349 : Alhazzazi, Kamarajan, Joo, Huang, Verdin, DSilva, Kapila: Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. dans Cancer 2011 (PubMed)

  3. Human Polyclonal SIRT5 Primary Antibody pour IHC (fro), IF (p) - ABIN1387080 : Takumida, Takumida, Anniko: Localization of sirtuins in the mouse inner ear. dans Acta oto-laryngologica 2014 (PubMed)

  4. Human Polyclonal SIRT5 Primary Antibody pour IHC, IHC (p) - ABIN4353920 : Lv, Liu, Cheng, Yu, Xiong, Hu, Tang, Zeng, Sang: SUN2 exerts tumor suppressor functions by suppressing the Warburg effect in lung cancer. dans Scientific reports 2015 (PubMed)

  5. Cow (Bovine) Polyclonal SIRT5 Primary Antibody pour WB - ABIN2778619 : Mahlknecht, Ho, Letzel, Voelter-Mahlknecht: Assignment of the NAD-dependent deacetylase sirtuin 5 gene (SIRT5) to human chromosome band 6p23 by in situ hybridization. dans Cytogenetic and genome research 2006 (PubMed)
    Show all 2 Pubmed References

Plus d’anticorps contre Sirtuin 5 partenaires d’interaction

Human Sirtuin 5 (SIRT5) interaction partners

  1. study thus uncovers an important role of SIRT5 in regulating cellular energy metabolism and AMPK activation in response to energy stress.

  2. findings illustrate the molecular mechanism underlying the sequence-selective desuccinylase activity of Sirt5 and provide insights for further studies of the biological functions associated with histone succinylation and Sirt5.

  3. mitochondrial dysfunction-mediated the fall in angiogenic capacity due to deficient CXCR4/JAK2/SIRT5 signaling of late EPCs is, at least in part, related to the capillary rarefaction in hypertension, providing the novel insight into the potential of late EPC mitochondria as a novel target for the treatment of hypertension-related loss of microvascular density

  4. Sirt5 inhibitors in combination with chemotherapeutic agents and/or cetuximab may represent a therapeutic strategy for colorectal cancer patients harboring wild-type Kras.

  5. Our study reveals a novel role of SIRT5 in inhibiting peroxisome-induced oxidative stress, in liver protection, and in suppressing hepatocellular carcinoma development.

  6. Hepatic overexpression of SIRT5 ameliorated the metabolic abnormalities of ob/ob mice, probably through demalonylating and desuccinylating proteins in the main metabolic pathways. SIRT5 and related acylation might be potential targets for metabolic disorders.

  7. SIRT5 plays pivotal roles in cardiac physiology and stress responses and is involved in the regulation of numerous aspects of myocardial energy metabolism. SIRT5 is implicated in neoplasia, as both a tumor promoter and suppressor in a context-specific manner, and may serve a protective function in the setting of neurodegenerative disorders.

  8. In human beings, SIRT5 gene encodes for four SIRT5 protein isoforms, namely SIRT5iso1, SIRT5iso2, SIRT5iso3, and SIRT5iso4. SIRT5(iso1-3) were mitochondria-localized, while SIRT5(iso4) localized mainly in cytoplasm. SIRT5(iso2-4) had little deacylase activity comparing with SIRT5(iso1).

  9. miR-299-3p suppresses migration, invasion and proliferation of Hepatocellular carcinoma cells via directly targeting SIRT5

  10. High SIRT5 expression is associated with Cancer Cell Proliferation.

  11. The DNA variants and SNPs identified in acute Myocardial infection (AMI) patients may change SIRT5 level by affecting activity of SIRT5 gene promoter, contributing to the AMI development as a risk factor.

  12. In this study, we summarize biological functions of SIRT5 reported in normal tissues and in cancer and discuss potential mechanisms whereby SIRT5 may impact tumorigenesis, particularly focusing on its reported roles in metabolic reprogramming. Finally, we review current efforts to target SIRT5 pharmacologically

  13. The roles of the CDK2/SIRT5 axis in gastric cancer.

  14. SIRT5 gene has an important regulatory role in liver carcinogenesis, and may function as a novel potential therapeutic target for HCC.

  15. This study showed that SIRT5 supports the anaplerotic entry of glutamine into the TCA cycle in malignant phenotypes of CRC via activating GLUD1.

  16. Results show that SIRT5 binds to, desuccinylates and inhibits PKM2 activity. Increased levels of reactive oxygen species (ROS) decreases succinylation and activity of PKM2 by increasing its binding to SIRT5. Moreover, inhibition of SIRT5 suppresses tumor cell proliferation through desuccinylation of PKM2 K498.

  17. The function of the three mitochondrial sirtuins (SIRT3, SIRT4, SIRT5) and their role in disease are reviewed.

  18. Our study uncovers a SIRT5-dependent mechanism that regulates cellular NADPH homeostasis and redox potential by promoting IDH2 desuccinylation and G6PD deglutarylation.

  19. Results demonstrated presence of endogenous SIRT5 in mitochondria of cultured SH-EP cells, identified down-regulation of cellular oxidative stress by SIRT5 as one of the possible mechanisms mediating the anti-apoptotic effect of SIRT5 in SH-EP cells.

  20. Data (including data from studies using knockout mice) suggest that SIRT5 is targeted to protein complexes on the inner mitochondrial membrane via affinity for cardiolipin to promote respiratory chain function, particularly Complex I and Complex II; SIRT5 expression is observed in inner mitochondrial membrane of periportal hepatocytes.

Mouse (Murine) Sirtuin 5 (SIRT5) interaction partners

  1. study thus uncovers an important role of SIRT5 in regulating cellular energy metabolism and AMPK activation in response to energy stress.

  2. Massspectrometry-based quantification of succinylationreveals that Sirt5 regulates the key thermogenic pro-tein in BAT, UCP1. Mutation of the two succinylatedlysines in UCP1 to acyl-mimetic glutamine and gluta-mic acid significantly decreases its stability andactivity.

  3. SIRT5 deficiency does not affect immune cell development, cytokine production and proliferation by macrophages and splenocytes exposed to microbial and immunological stimuli.

  4. Both diabetic rats and mice demonstrated significantly weakened SIRT5 expression in the pancreas, compared to wild-type animals, implying a possible correlation between SIRT5 and pancreatic beta cell function.

  5. Our study reveals a novel role of SIRT5 in inhibiting peroxisome-induced oxidative stress, in liver protection, and in suppressing hepatocellular carcinoma development.

  6. It confirms the role of Sirt5 as an important demalonylase and desuccinylase enzyme in vivo, but questions the relevance of physiological changes in mitochondrial protein acylation levels in the regulation of cellular metabolism.

  7. Loss of SIRT5 expression is associated with cardiac hypertrophy.

  8. Data indicate that sirtuin 5 (SIRT5) is an important mitochondrial enzyme for protection against metabolic and ischemic stress following protein kinase C epsilon (PKCepsilon) activation in the brain.

  9. findings reveal a key role for SIRT5 in maintaining cardiac oxidative metabolism under pressure overload to ensure survival

  10. Deletion of Sirt5 in starved mouse embryonic fibroblasts increased levels of mitochondrial dynamics leading to mitochondrial accumulation of the pro-fission Drp1 and to mitochondrial fragmentation.

  11. Our study uncovers a SIRT5-dependent mechanism that regulates cellular NADPH homeostasis and redox potential by promoting IDH2 desuccinylation and G6PD deglutarylation.

  12. Data (including data from studies using knockout mice) suggest that SIRT5 is targeted to protein complexes on the inner mitochondrial membrane via affinity for cardiolipin to promote respiratory chain function, particularly Complex I and Complex II; SIRT5 expression is observed in inner mitochondrial membrane of periportal hepatocytes.

  13. Data show that peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) overexpression significantly increased the expression of sirtuin 3 (SIRT3) and sirtuin 5 (SIRT5).

  14. In the cochlea, the expression of SIRT1, 3, and 5 (both mRNA and protein) was decreased in the old mice

  15. These findings establish that regulating heart metabolism and function is a major physiological function of lysine succinylation and SIRT5.

  16. Myocardial ischemic reperfusion injury in Sirt5-/- heart is restored to wild-type levels by pretreatment with dimethyl malonate, a competitive inhibitor of succinate dehydrogenase (SDH), implicating alteration in SDH activity as causative of the injury.

  17. SIRT5 has a role in cellular metabolism with a multiple enzymatic activities

  18. SIRT3 and SIRT5 regulate the enzyme activity and cardiolipin binding of very long-chain acyl-CoA dehydrogenase

  19. Pathway analysis identified glycolysis as the top SIRT5-regulated pathway. Importantly, glycolytic flux was diminished in primary hepatocytes from Sirt5(-/-) compared to WT mice.

  20. Data indicated that SIRT5 ameliorates MPTP-induced nigrostriatal dopaminergic degeneration via preserving mitochondrial antioxidant capacity.

Cow (Bovine) Sirtuin 5 (SIRT5) interaction partners

  1. We further analyzed the regulatory elements in the SIRT5 promoter region of -239/-18bp using the Genomatix suite. Two motifs as TF binding sites for E2F4 and KLF6, which contained two methylation sites, were identified in this region (Fig. 1B). Additionally, we found that the methylation level of CpG in the SIRT5 promoter in differentiation adipocytes was enhanced compared to that present in undifferentiation adipocytes

  2. Association analysis of individual SIRT5 SNPs and haplotype combinations reveal that the 4 loci are significantly associated with some body measurement and ultrasound traits in Qinchuan cattle.

Sirtuin 5 (SIRT5) profil antigène

Profil protéine

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants.

Gene names and symbols associated with anti-Sirtuin 5 (SIRT5) Anticorps

  • sirtuin 5 (SIRT5) anticorps
  • sirtuin 5 (Sirt5) anticorps
  • sirtuin 5 (sirt5) anticorps
  • sirtuin 5 L homeolog (sirt5.L) anticorps
  • sirtuin 5 (CC1G_00083) anticorps
  • 0610012J09Rik anticorps
  • 1500032M05Rik anticorps
  • AV001953 anticorps
  • sir2l5 anticorps
  • SIRT5 anticorps
  • sirt5-a anticorps
  • zgc:92288 anticorps

Protein level used designations for anti-Sirtuin 5 (SIRT5) Anticorps

NAD-dependent deacetylase sirtuin-5 , NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial , NAD-dependent protein deacylase sirtuin-5, mitochondrial , SIR2-like protein 5 , regulatory protein SIR2 homolog 5 , silent mating type information regulation 2, S.cerevisiae, homolog 5 , sir2-like 5 , sirtuin type 5 , Regulatory protein SIR2 homolog 5 , NAD-dependent lysine demalonylase and desuccinylase sirtuin-5A, mitochondrial , NAD-dependent protein deacylase sirtuin-5A, mitochondrial , regulatory protein SIR2 homolog 5-a , sirtuin (silent mating type information regulation 2 homolog) 5 , sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) , sirtuin 5 , nad-dependent deacetylase sirtuin-5

GENE ID SPECIES
23408 Homo sapiens
68346 Mus musculus
306840 Rattus norvegicus
420834 Gallus gallus
436878 Danio rerio
478726 Canis lupus familiaris
496346 Xenopus laevis
507347 Bos taurus
700855 Macaca mulatta
747069 Pan troglodytes
6013501 Coprinopsis cinerea okayama7130
100125966 Sus scrofa
100170199 Xenopus (Silurana) tropicalis
100173543 Pongo abelii
100528250 Ictalurus punctatus
100718110 Cavia porcellus
100339154 Oryctolagus cuniculus
100860989 Capra hircus
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