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SPEN encodes a hormone inducible transcriptional repressor.
Showing 10 out of 21 products:
Human Polyclonal SPEN Primary Antibody pour ELISA - ABIN251251
Hiriart, Gruffat, Buisson, Mikaelian, Keppler, Meresse, Mercher, Bernard, Sergeant, Manet: Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export. dans The Journal of biological chemistry 2005
Human Polyclonal SPEN Primary Antibody pour ICC, IF - ABIN4355627
McHugh, Chen, Chow, Surka, Tran, McDonel, Pandya-Jones, Blanco, Burghard, Moradian, Sweredoski, Shishkin, Su, Lander, Hess, Plath, Guttman: The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3. dans Nature 2015
This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator\; this binding can modulate the activity of both liganded and nonliganded steroid receptors.
Msx2 interacting nuclear target (MINT) homolog
, SMART/HDAC1 associated repressor protein
, SMART/HDAC1-associated repressor protein
, msx2-interacting protein
, nuclear receptor transcription cofactor
, spen homolog, transcriptional regulator (Drosophila)
, Msx2 interacting nuclear target protein