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The protein encoded by SKAP2 belongs to the src family kinases. De plus, nous expédions SKAP2 Protéines (12) et et beaucoup plus de produits pour cette protéine.
Showing 10 out of 79 products:
Human Polyclonal SKAP2 Primary Antibody pour ELISA, WB - ABIN258262
Takahashi, Yamashita, Nagano, Nakamura, Ohmori, Avraham, Avraham, Yasuda, Matsumoto: Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation. dans The Journal of biological chemistry 2003
Skap2 is essential to activate the beta2 integrins, and loss of Skap2 function is sufficient to cause a leukocyte adhesion deficiency (LAD (Montrer ITGB2 Anticorps))-like phenotype in mice.
Macrophages assemble the appropriate motile machinery to infiltrate tumors and promote disease progression, and implicate SKAP2 as an attractive candidate for therapeutically targeting TAMs.
RA70/Scap2 may be necessary for RA-induced neuronal differentiation from the posterior neuroectoderm.
a novel role of SKAP-Hom and its phosphorylation in the regulation of cellular motility.
integrin activation by the ADAP (Montrer APP Anticorps)-SKAP55 (Montrer SKAP1 Anticorps)-signaling module controls the stability and duration of T cell-dendritic cell contacts during the progressive phases necessary for optimal T cell activation.
Sirpalpha is not exclusively immunoinhibitory, and illuminate previously unexplained observations implicating Skap2 and Sirpalpha in mouse models of inflammatory disease.
These results revealed an essential role for HSF4-mediated SKAP2 expression in the regulation of actin reorganization during lens differentiation.
M-CSF receptor induces tyrosine phosphorylation of SKAP55R adaptor and its association with actin
SKAP-HOM is required for proper activation of the immune system, likely by regulating the cross-talk between immunoreceptors and integrins.
A signaling module comprising the cytosolic adapter proteins ADAP (Montrer APP Anticorps) and SKAP55 (Montrer SKAP1 Anticorps) is involved in TCR-mediated inside-out signaling and, the interaction between ADAP (Montrer APP Anticorps) and SKAP55 (Montrer SKAP1 Anticorps) is mandatory for integrin activation.
Skap2 is necessary for macrophage migration, chemotaxis, global actin reorganization and local actin reorganization upon integrin engagement.
SKAP2 expression levels in NSCLC tissues could be a powerful biomarker of poor prognosis. Therefore, SKAP2 is a promising candidate molecular target for Non-small cell lung cancer treatment.
results suggest that SKAP2 negatively regulates cell migration and tumor invasion in fibroblasts and glioblastoma cells by suppressing actin assembly induced by the WAVE2 (Montrer WASF2 Anticorps)-cortactin (Montrer CTTN Anticorps) complex
analysis of substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp (Montrer PTPN22 Anticorps)) and identification of Src kinase (Montrer CSK Anticorps)-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp (Montrer PTPN22 Anticorps) substrate
cloning & characterization of an adaptor protein that functions as a downstream target for RAFTK & plays a role in alpha-synuclein phosphorylation
studies provide insights into the molecular mechanism ofrelated adhesion focal tyrosine kinase (Montrer TXK Anticorps) (RAFTK (Montrer PTK2B Anticorps)) autophosphorylation and the specific role of Src (Montrer SRC Anticorps) in the regulation of RAFTK (Montrer PTK2B Anticorps) activation
Overexpression of SKAP2 is associated with the development of pancreatic ductal adenocarcinoma
The protein encoded by this gene belongs to the src family kinases. This protein is similar to the src kinase associated phosphoprotein 1. It is an adaptor protein that is thought to play an essential role in the src signaling pathway in various cells. It inhibits PTK2B/RAFTK activity and regulates alpha-synuclein phosphorylation.
src kinase-associated phosphoprotein 2-B
, SRC kinase associated phosphoprotein 2
, SKAP55 homolog
, SKAP55 homologue
, Src-associated adaptor protein
, pyk2/RAFTK-associated protein
, src family-associated phosphoprotein 2
, src kinase-associated phosphoprotein 2
, src kinase-associated phosphoprotein 55-related protein
, src-associated adapter protein with PH and SH3 domains
, Fyn-associated phosphoprotein SKAP55 homologue
, Pyk2/RAFTK-associated protein
, retinoic acid-induced protein 70
, src family associated phosphoprotein 2
, src kinase-associated phosphoprotein of 55-related protein
, src-associated adaptor protein
, Src kinase-associated phosphoprotein 2