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Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control.
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cloning and characterization of tumor necrosis factor receptor 1 (TNF-R1 (Montrer TNFRSF1A Protéines))-associated ubiquitous scaffolding and signaling protein (TRUSS)
TRUSS is a novel substrate of E3 ligase Skp2.
The latent classification method of analysis showed that the TRPC4AP H1 haplotype was characteristic of Alzheimer's patients, with ages-of-onset between 66 and 80 years.
These findings suggest that TNF-R1 (Montrer TNFRSF1A Protéines), TRUSS, and TRPC4 (Montrer TRPC4 Protéines) augment Ca(2 (Montrer CA2 Protéines)+) loading of endoplasmic reticulum Ca(2 (Montrer CA2 Protéines)+) stores in the context of m1AchR stimulation
TRPC4AP/TRUSS binds specifically to the Myc (Montrer MYC Protéines) C terminus and promotes its ubiquitination and destruction through the recognition of evolutionarily conserved domains in the Myc (Montrer MYC Protéines) N terminus
results suggest that TRPC4AP is involved with the disease in these late-onset Alzheimer's families
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.
short transient receptor potential channel 4-associated protein
, transient receptor potential cation channel, subfamily C, member 4 associated protein
, TRPC4-associated protein
, TRPC4-associated protein-like
, short transient receptor potential channel 4-associated protein-like
, TNF-receptor ubiquitous scaffolding/signaling protein
, Trp4-associated protein TAP1
, rabex-5/Rin2-interacting protein
, transient receptor protein 4, associated protein
, trpc4-associated protein
, TRP4-associated protein
, short transient receptor potential channel 4 associated protein
, tumor necrosis factor receptor-associated ubiquitous scaffolding and signaling protein