Transient Receptor Potential Cation Channel, Subfamily C, Member 4 Associated Protein Protéines (TRPC4AP)

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control.

afficher tous les protéines Gène GeneID UniProt
Souris TRPC4AP TRPC4AP 56407 Q9JLV2
Humain TRPC4AP TRPC4AP 26133 Q8TEL6
Rat TRPC4AP TRPC4AP 362247  
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$12,127.90
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Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$12,127.90
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Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
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Plus protéines pour Transient Receptor Potential Cation Channel, Subfamily C, Member 4 Associated Protein (TRPC4AP) partenaires d'interaction

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily C, Member 4 Associated Protein (TRPC4AP) interaction partners

  1. cloning and characterization of tumor necrosis factor receptor 1 (TNF-R1 (Montrer TNFRSF1A Protéines))-associated ubiquitous scaffolding and signaling protein (TRUSS)

Human Transient Receptor Potential Cation Channel, Subfamily C, Member 4 Associated Protein (TRPC4AP) interaction partners

  1. TRUSS is a novel substrate of E3 ligase Skp2.

  2. The latent classification method of analysis showed that the TRPC4AP H1 haplotype was characteristic of Alzheimer's patients, with ages-of-onset between 66 and 80 years.

  3. These findings suggest that TNF-R1 (Montrer TNFRSF1A Protéines), TRUSS, and TRPC4 (Montrer TRPC4 Protéines) augment Ca(2 (Montrer CA2 Protéines)+) loading of endoplasmic reticulum Ca(2 (Montrer CA2 Protéines)+) stores in the context of m1AchR stimulation

  4. TRPC4AP/TRUSS binds specifically to the Myc (Montrer MYC Protéines) C terminus and promotes its ubiquitination and destruction through the recognition of evolutionarily conserved domains in the Myc (Montrer MYC Protéines) N terminus

  5. results suggest that TRPC4AP is involved with the disease in these late-onset Alzheimer's families

Profil protéine Transient Receptor Potential Cation Channel, Subfamily C, Member 4 Associated Protein (TRPC4AP)

Profil protéine

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.

Gene names and symbols associated with TRPC4AP

  • transient receptor potential cation channel subfamily C member 4 associated protein (TRPC4AP)
  • transient receptor potential cation channel, subfamily C, member 4 associated protein L homeolog (trpc4ap.L)
  • transient receptor potential cation channel, subfamily C, member 4 associated protein (trpc4ap)
  • transient receptor potential cation channel subfamily C member 4 associated protein (trpc4ap)
  • transient receptor potential cation channel, subfamily C, member 4 associated protein (Trpc4ap)
  • 4833429F06Rik Protéine
  • C20orf188 Protéine
  • D2Ertd113e Protéine
  • mFLJ00177 Protéine
  • MGC130977 Protéine
  • TRPC4AP Protéine
  • TRRP4AP Protéine
  • TRUSS Protéine

Protein level used designations for TRPC4AP

short transient receptor potential channel 4-associated protein , transient receptor potential cation channel, subfamily C, member 4 associated protein , TRPC4-associated protein , TRPC4-associated protein-like , short transient receptor potential channel 4-associated protein-like , TNF-receptor ubiquitous scaffolding/signaling protein , Trp4-associated protein TAP1 , rabex-5/Rin2-interacting protein , transient receptor protein 4, associated protein , trpc4-associated protein , TRP4-associated protein , short transient receptor potential channel 4 associated protein , tumor necrosis factor receptor-associated ubiquitous scaffolding and signaling protein

GENE ID SPECIES
428134 Gallus gallus
458196 Pan troglodytes
532834 Bos taurus
712164 Macaca mulatta
734909 Xenopus laevis
100145210 Xenopus (Silurana) tropicalis
100345322 Oryctolagus cuniculus
100449842 Pongo abelii
100543270 Meleagris gallopavo
100561242 Anolis carolinensis
100069434 Equus caballus
100396278 Callithrix jacchus
100469662 Ailuropoda melanoleuca
56407 Mus musculus
26133 Homo sapiens
477207 Canis lupus familiaris
362247 Rattus norvegicus
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