anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) Anticorps

The protein encoded by TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. De plus, nous expédions TRPM2 Protéines (6) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
TRPM2 7226 O94759
TRPM2 294329  
TRPM2 28240  
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Top anti-TRPM2 Anticorps sur anticorps-enligne.fr

Showing 10 out of 95 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Souris Lapin Inconjugué ICC, IHC (fro), IF, IHC, WB Staining of rat hippocampus using ABIN259658. TRPM2 is stained red, GFAP is stained green and nuclei staining is blue. Photo courtesy of Dr. Ji-Zhong Bai, The University of Auckland, New Zealand. 0.1 mL Connectez-vous pour afficher 7 to 9 Days
$444.19
Détails
Humain Lapin Inconjugué IHC (p), WB Anti-TRPM2 antibody, IHC(P) IHC(P): Rat Brain Tissue Anti-TRPM2 antibody, Western blotting Lane 1: Rat Brain Tissue Lysate Lane 2: Mouse Brain Tissue Lysate Lane 3: Mouse Liver Tissue Lysate Lane 4: JURKAT Cell Lysate Lane 5: HELA Cell Lysate Lane 6: A549 Cell Lysate 100 μg Connectez-vous pour afficher 4 to 6 Days
$240.00
Détails
Humain Lapin Inconjugué ICC, IHC (fro), IF, IP, IHC, WB Western Blot: TRPM2 Antibody  - Samples: Membrane Prep (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from Jurkat cells. Antibodies: Affinity purified rabbit anti-TRPM2 antibody (lot was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds. Western Blot: TRPM2 Antibody  - Samples: Jurkat Membrane Prep (50, 15, 5 ug). Antibody: Affinity purified rabbit anti-TRPM2 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Connectez-vous pour afficher 7 to 9 Days
$556.31
Détails
Humain Lapin Inconjugué ICC, IF, IP, WB Western Blot: TRPM2 Antibody [ABIN153041] - Membrane Prep (50 ug) from Jurkat cells. Antibody: Affinity purified rabbit anti-TRPM2 antibody used for WB at 2 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Connectez-vous pour afficher 7 to 9 Days
$556.31
Détails
Humain Chèvre Inconjugué IHC (p) Brain, cortex, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Pancreas, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Connectez-vous pour afficher 7 to 9 Days
$484.00
Détails
Cobaye Lapin Inconjugué IHC (p), WB Brain, cortex, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Heart, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Connectez-vous pour afficher 7 to 9 Days
$727.83
Détails
Souris Lapin Inconjugué ICC, IF, WB Detection of TRPM2 in mouse brain membrane lysates using ABIN259771. Immunocytochemistry/Immunofluorescence: TRPM2 Antibody [ABIN2597714] - TRPM2 antibody was tested in Neuro2A cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). 0.1 mL Connectez-vous pour afficher 7 to 9 Days
$415.44
Détails
Humain Lapin Inconjugué IHC (p), IHC, WB Western Blot: TRPM2 Antibody [NBP1-33416] - Sample (30 ug of whole cell lysate) A: Hep G2 7. 5% SDS PAGE, antibody diluted at 1:500. Immunohistochemistry-Paraffin: TRPM2 Antibody [NBP1-33416] - Paraffin-embedded MDAMB468 xenograft, using antibody at 1:100 dilution. 100 μL Connectez-vous pour afficher 7 to 9 Days
$514.63
Détails
Humain Chèvre Inconjugué IHC (p) Brain, cortex, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Pancreas, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Connectez-vous pour afficher 6 to 8 Days
$368.50
Détails

TRPM2 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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anti-TRPM2 Anticorps mieux référencés

  1. Mouse (Murine) Polyclonal TRPM2 Primary Antibody pour ICC, IHC (fro) - ABIN259658 : Bai, Lipski: Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture. dans Neurotoxicology 2010 (PubMed)
    Show all 8 Pubmed References

  2. Human Polyclonal TRPM2 Primary Antibody pour ICC, IHC (fro) - ABIN153042 : Partida-Sanchez, Gasser, Fliegert, Siebrands, Dammermann, Shi, Mousseau, Sumoza-Toledo, Bhagat, Walseth, Guse, Lund: Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the CD38 enzyme reaction. dans Journal of immunology (Baltimore, Md. : 1950) 2007 (PubMed)
    Show all 4 Pubmed References

  3. Polyclonal TRPM2 Primary Antibody pour WB - ABIN540252 : Zhang, Chu, Tong, Cheung, Conrad, Masker, Miller: A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death. dans The Journal of biological chemistry 2003 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal TRPM2 Primary Antibody pour ICC, IF - ABIN153041 : Moreau, Kirchberger, Swarbrick, Bartlett, Fliegert, Yorgan, Bauche, Harneit, Guse, Potter: Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists. dans Journal of medicinal chemistry 2013 (PubMed)
    Show all 2 Pubmed References

  5. Mouse (Murine) Polyclonal TRPM2 Primary Antibody pour ICC, IF - ABIN4362934 : Rah, Kwak, Chung, Kim: ADP-ribose/TRPM2-mediated Ca2+ signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells. dans Scientific reports 2015 (PubMed)

Plus d’anticorps contre TRPM2 partenaires d’interaction

Human Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. oxidative stress activates the TRPM2 (Montrer CLU Anticorps)-Ca(2 (Montrer CA2 Anticorps)+)-CAMK2 (Montrer CAMK2B Anticorps) cascade to phosphorylate BECN1 (Montrer BECN1 Anticorps) resulting in autophagy inhibition

  2. We conclude from these studies that inhibition of ROS (Montrer ROS1 Anticorps) production, and the subsequent abrogation of TRPM2 (Montrer CLU Anticorps)-mediated Ca(2 (Montrer CA2 Anticorps)+) influx, is the primary mechanism underlying RE-1's inhibitory effect on LNs-induced inflammasome activation.

  3. oxidative stress activated the TRPM2 (Montrer CLU Anticorps)-CaMKII (Montrer CAMK2G Anticorps) cascade to further induce intracellular ROS (Montrer ROS1 Anticorps) production, which led to mitochondria fragmentation and loss of mitochondrial membrane potential

  4. The work summarized here shows that TRPM2 (Montrer CLU Anticorps) channels protect cardiac myocytes from ischaemia-reperfusion injury and tumour cells from doxorubicin toxicity, and demonstrates that the mechanisms involve preservation of mitochondrial bioenergetics and modulation of ROS (Montrer ROS1 Anticorps)

  5. Activation of TRPM2 (Montrer CLU Anticorps) channels, however, caused intracellular release of not only Ca(2 (Montrer CA2 Anticorps)+) but also of Zn(2+) Intriguingly, elevation of intracellular Zn(2+) faithfully reproduced all of the effects of H2O2, whereas Ca(2 (Montrer CA2 Anticorps)+) showed opposite effects. Interestingly, H2O2 caused increased trafficking of Zn(2+)-enriched lysosomes to the leading edge of migrating cells, presumably to impart polarisation of Zn(2+) location.

  6. neutrophils sense reactive oxygen species via the TRPM2 (Montrer CLU Anticorps) channel to arrest migration at their target site.

  7. The inhibitory function of oxidant sensing by TRPM2 (Montrer CLU Anticorps) requires the oxidation of Cys549, which then induces TRMP2 binding to formyl peptide receptor 1 (FPR1 (Montrer FPR1 Anticorps)) and subsequent FPR1 (Montrer FPR1 Anticorps) internalization and signaling inhibition

  8. findings demonstrate the important function of TRPM2 (Montrer CLU Anticorps) in modulation of cell survival through mitochondrial ROS (Montrer ROS1 Anticorps), and the potential of targeted inhibition of TRPM2 (Montrer CLU Anticorps) as a therapeutic approach to reduce cellular bioenergetics, tumor growth, and enhance susceptibility to chemotherapeutic agents.

  9. Study demonstrate that PRL (Montrer PRL Anticorps) is necessary for the survival of (retinal pigment epithelium) RPE (Montrer RPE Anticorps) under normal and advancing age conditions and, identified SIRT2 (Montrer SIRT2 Anticorps) and TRPM2 (Montrer CLU Anticorps) as molecular targets for the antioxidant and antiapoptotic actions of PRL (Montrer PRL Anticorps) in the RPE (Montrer RPE Anticorps).

  10. TRPM2 (Montrer CLU Anticorps) has a role in the DNA damage response of T cell leukemia cells in a BCL-2 (Montrer BCL2 Anticorps) dependent manner

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. Studied the role of transient receptor potential melastatin 2 (Montrer TRPM3 Anticorps) (TRPM2) in activating caspase-1 (Montrer CASP1 Anticorps) and caspase-1 (Montrer CASP1 Anticorps)-dependent pyroptosis in mouse BMDMs. Found TRPM2 knockout caused higher caspase-1 (Montrer CASP1 Anticorps) activation and pyrotopsis.

  2. Transient receptor potential melastatin-2 (TRPM2) in pituitary nerve terminals plays a role in oxytocin release. Temperature- enhanced oxytocin release by CD38 and TRPM2. TRPM2 might be involved in the process of CD38-regulated oxytocin release.

  3. this study shows that TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection

  4. Overexpression of TRPM2 channel prevented neutrophil transendothelial migration and vascular injury.

  5. These findings of this study suggest that TRPM2 channels play an essential role in mediating hypoxic-ischemic brain injury in neonatal mice.

  6. TRPM2 regulates phagosomal acidification, and is essential for the bacterial killing function of macrophages.

  7. Lysophosphatidylcholine induces intracellular Ca(2 (Montrer CA2 Anticorps)+) influx and increases phosphorylation of p38 MAPK (Montrer MAPK14 Anticorps) via TRPM2, which in turn activates microglia.

  8. The current study demonstrated that a physiological concentration of adrenaline attenuates insulin (Montrer INS Anticorps) release via coupling of alpha2A-adrenoceptor to cAMP/TRPM2 signaling.

  9. Trpm2 does not seem to play a major role in myeloid leukemogenesis. Additionally, loss of Trpm2 does not augment the cytotoxicity of standard AML (Montrer RUNX1 Anticorps) chemotherapeutic agents.

  10. TRPM2 channels contribute to visceral nociception in response to noxious stimuli under normal conditions and visceral hypersensitivity in pathological conditions.

Pig (Porcine) Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. Study determined the sequence of pig TRPC1 and TRPC3-7 channels and found pig TRPC cDNAs resemble their human homologs more than the others .

  2. heteromeric cation channels comprised of the TRPP2 mutant and the TRPC3 (Montrer TRPC3 Anticorps) or TRPC7 protein induce enhanced receptor-activated Ca(2 (Montrer CA2 Anticorps)+) influx that may lead to dysregulated cell growth in ADPKD

TRPM2 profil antigène

Profil protéine

The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Gene names and symbols associated with TRPM2

  • transient receptor potential cation channel subfamily M member 2 (TRPM2) anticorps
  • transient receptor potential cation channel, subfamily M, member 2 (Trpm2) anticorps
  • transient receptor potential cation channel subfamily C member 6 (TRPC6) anticorps
  • transient receptor potential cation channel, subfamily M, member 2 (trpm2) anticorps
  • transient receptor potential cation channel subfamily C member 7 (TRPC7) anticorps
  • short transient receptor potential channel 7 (LOC100443123) anticorps
  • short transient receptor potential channel 7 (LOC100539776) anticorps
  • transient receptor potential cation channel subfamily M member 2 (trpm2) anticorps
  • transient receptor potential cation channel subfamily M member 2 (Trpm2) anticorps
  • 9830168K16Rik anticorps
  • C79133 anticorps
  • EREG1 anticorps
  • KNP3 anticorps
  • LTRPC2 anticorps
  • NUDT9H anticorps
  • NUDT9L1 anticorps
  • si:ch73-263b18.1 anticorps
  • Trp7 anticorps
  • TRPC7 anticorps
  • TRPM2 anticorps
  • Trpm2-predicted anticorps
  • Trrp7 anticorps

Protein level used designations for TRPM2

LTrpC-2 , estrogen-responsive element-associated gene 1 protein , long transient receptor potential channel 2 , transient receptor potential cation channel subfamily M member 2 , transient receptor potential channel 7 , transient receptor potential melastatin family 2 , transient receptor potential cation channel, subfamily M, member 2 , transient receptor potential cation channel, subfamily C, member 7 , transient receptor potential cation channel, subfamily C, member 7-like , short transient receptor potential channel 7-like , transient receptor potential cation channel subfamily M member 2-like , transient receptor protein 7 , transient receptor potential channel subfamily C member 7

GENE ID SPECIES
7226 Homo sapiens
294329 Rattus norvegicus
424835 Gallus gallus
470101 Pan troglodytes
508029 Bos taurus
703611 Macaca mulatta
799412 Danio rerio
100056810 Equus caballus
100083361 Ornithorhynchus anatinus
100124999 Xenopus (Silurana) tropicalis
100341596 Oryctolagus cuniculus
100443123 Pongo abelii
100479298 Ailuropoda melanoleuca
100479364 Ailuropoda melanoleuca
100539776 Meleagris gallopavo
100556895 Anolis carolinensis
28240 Mus musculus
100271727 Sus scrofa
100720314 Cavia porcellus
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