anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) Anticorps

The protein encoded by TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. De plus, nous expédions TRPM2 Protéines (6) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
TRPM2 7226 O94759
TRPM2 294329  
TRPM2 28240  
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Top anti-TRPM2 Anticorps sur anticorps-enligne.fr

Showing 10 out of 108 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB 100 μL Connectez-vous pour afficher 2 to 3 Days
$319.00
Détails
Souris Lapin Inconjugué ICC, IHC (fro), IF, IHC, WB Staining of rat hippocampus using ABIN259658. TRPM2 is stained red, GFAP is stained green and nuclei staining is blue. Photo courtesy of Dr. Ji-Zhong Bai, The University of Auckland, New Zealand. 0.1 mL Connectez-vous pour afficher 7 to 9 Days
$446.35
Détails
Humain Lapin Inconjugué ICC, IF, IP, WB Western Blot: TRPM2 Antibody [ABIN153041] - Membrane Prep (50 ug) from Jurkat cells. Antibody: Affinity purified rabbit anti-TRPM2 antibody used for WB at 2 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Connectez-vous pour afficher 7 to 9 Days
$559.35
Détails
Humain Lapin Inconjugué IHC (p), IHC, WB Western Blot: TRPM2 Antibody [NBP1-33416] - Sample (30 ug of whole cell lysate) A: Hep G2 7. 5% SDS PAGE, antibody diluted at 1:500. Immunohistochemistry-Paraffin: TRPM2 Antibody [NBP1-33416] - Paraffin-embedded MDAMB468 xenograft, using antibody at 1:100 dilution. 100 μL Connectez-vous pour afficher 8 to 11 Days
$516.98
Détails
Humain Lapin Inconjugué ICC, IHC (fro), IF, IP, IHC, WB Western Blot: TRPM2 Antibody  - Samples: Membrane Prep (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from Jurkat cells. Antibodies: Affinity purified rabbit anti-TRPM2 antibody (lot was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds. Western Blot: TRPM2 Antibody  - Samples: Jurkat Membrane Prep (50, 15, 5 ug). Antibody: Affinity purified rabbit anti-TRPM2 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Connectez-vous pour afficher 7 to 9 Days
$559.35
Détails
Humain Chèvre Inconjugué IHC, IHC (p) Brain, cortex, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Pancreas, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Connectez-vous pour afficher 11 to 14 Days
$484.00
Détails
Cobaye Lapin Inconjugué IHC, IHC (p), WB Brain, cortex, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Heart, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Connectez-vous pour afficher 11 to 14 Days
$727.83
Détails
Souris Lapin Inconjugué ICC, IF, WB Detection of TRPM2 in mouse brain membrane lysates using ABIN259771. Immunocytochemistry/Immunofluorescence: TRPM2 Antibody [ABIN2597714] - TRPM2 antibody was tested in Neuro2A cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). 0.1 mL Connectez-vous pour afficher 7 to 9 Days
$418.10
Détails
Humain Lapin Inconjugué ELISA, IHC, WB Western blot analysis of TRPM2 using K562 whole cell lysates Western blot analysis of extracts from mouse brain, using TRPM2 Antibody. 100 μL Connectez-vous pour afficher 11 to 12 Days
$390.77
Détails
Humain Chèvre Inconjugué IHC (p) Immunohistochemistry-Paraffin: TRPM2 Antibody  - Analysis of anti-TRPM2 antibody with human brain, cortex at concentration 3.75 ug/ml. Immunohistochemistry-Paraffin: TRPM2 Antibody  - Analysis of anti-TRPM2 antibody with human pancreas at concentration 3.75 ug/ml. 0.05 mg Connectez-vous pour afficher 10 to 13 Days
$559.35
Détails

anti-TRPM2 Anticorps mieux référencés

  1. Mouse (Murine) Polyclonal TRPM2 Primary Antibody pour ICC, IHC (fro) - ABIN259658 : Bai, Lipski: Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture. dans Neurotoxicology 2010 (PubMed)
    Show all 8 Pubmed References

  2. Human Polyclonal TRPM2 Primary Antibody pour ICC, IHC (fro) - ABIN153042 : Partida-Sanchez, Gasser, Fliegert, Siebrands, Dammermann, Shi, Mousseau, Sumoza-Toledo, Bhagat, Walseth, Guse, Lund: Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the CD38 enzyme reaction. dans Journal of immunology (Baltimore, Md. : 1950) 2007 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal TRPM2 Primary Antibody pour ICC, IF - ABIN153041 : Moreau, Kirchberger, Swarbrick, Bartlett, Fliegert, Yorgan, Bauche, Harneit, Guse, Potter: Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists. dans Journal of medicinal chemistry 2013 (PubMed)
    Show all 3 Pubmed References

  4. Polyclonal TRPM2 Primary Antibody pour WB - ABIN540252 : Zhang, Chu, Tong, Cheung, Conrad, Masker, Miller: A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death. dans The Journal of biological chemistry 2003 (PubMed)
    Show all 2 Pubmed References

  5. Mouse (Murine) Polyclonal TRPM2 Primary Antibody pour ICC, IF - ABIN4362934 : Rah, Kwak, Chung, Kim: ADP-ribose/TRPM2-mediated Ca2+ signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells. dans Scientific reports 2015 (PubMed)

Plus d’anticorps contre TRPM2 partenaires d’interaction

Human Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. Cell culture, animal models, and patient samples established that TRPM2 expression/function is important for dopaminergic neuronal survival and is increased in neurotoxin models that mimic Parkinson's Disease.

  2. These findings explain the molecular mechanism of concerted TRPM2 gating by adenosine diphosphate (ADP)-ribose and Ca(2+) and provide insights into the gating mechanism of other TRP channels.

  3. Data suggest that TRPM2 plays roles in viability of gastric cancer cell line and in survival of gastric cancer patients; TRPM2 appears to regulate autophagy, mitophagy (mitochondrial degradation), and apoptosis; TRPM2 modulates autophagy through a c-Jun N-terminal kinase (JNK)-dependent mechanism.

  4. TRPM2 overexpression in a PDAC cell line (PANC1) promoted cell proliferation, invasion and metastatic ability. TRPM2 represents a potential therapeutic target and prognostic marker for patients with PDAC.

  5. The expression of TRPM2-AS was higher in most HCC tissues and was significantly correlated with tumor size, AJCC stage, tumor differentiation, and the prognosis of HCC patients. Interfering TRPM2-AS expression using siRNA significantly inhibited cell proliferation and promoted cell apoptosis in two HCC cell lines.

  6. Results reveal a novel, potentially druggable signalling pathway for FFA-induced beta-cell death. The cascade involves NOX-2-dependent production of ROS, activation of TRPM2 channels, rise in mitochondrial Zn(2+), Drp-1 recruitment and abnormal mitochondrial fission.

  7. TRPM2 is essential for the survival and migration of squamous cell cancer cells.

  8. Results provide compelling evidence to support a role for nitrosative stress in linking the TRPM2 turnover with the disturbance of autophagy in brain pericyte injury.

  9. oxidative stress activates the TRPM2-Ca(2+)-CAMK2 cascade to phosphorylate BECN1 resulting in autophagy inhibition

  10. We conclude from these studies that inhibition of ROS production, and the subsequent abrogation of TRPM2-mediated Ca(2+) influx, is the primary mechanism underlying RE-1's inhibitory effect on LNs-induced inflammasome activation.

  11. oxidative stress activated the TRPM2-CaMKII cascade to further induce intracellular ROS production, which led to mitochondria fragmentation and loss of mitochondrial membrane potential

  12. The work summarized here shows that TRPM2 channels protect cardiac myocytes from ischaemia-reperfusion injury and tumour cells from doxorubicin toxicity, and demonstrates that the mechanisms involve preservation of mitochondrial bioenergetics and modulation of ROS

  13. Activation of TRPM2 channels, however, caused intracellular release of not only Ca(2+) but also of Zn(2+) Intriguingly, elevation of intracellular Zn(2+) faithfully reproduced all of the effects of H2O2, whereas Ca(2+) showed opposite effects. Interestingly, H2O2 caused increased trafficking of Zn(2+)-enriched lysosomes to the leading edge of migrating cells, presumably to impart polarisation of Zn(2+) location.

  14. neutrophils sense reactive oxygen species via the TRPM2 channel to arrest migration at their target site.

  15. The inhibitory function of oxidant sensing by TRPM2 requires the oxidation of Cys549, which then induces TRMP2 binding to formyl peptide receptor 1 (FPR1) and subsequent FPR1 internalization and signaling inhibition

  16. findings demonstrate the important function of TRPM2 in modulation of cell survival through mitochondrial ROS, and the potential of targeted inhibition of TRPM2 as a therapeutic approach to reduce cellular bioenergetics, tumor growth, and enhance susceptibility to chemotherapeutic agents.

  17. Study demonstrate that PRL is necessary for the survival of (retinal pigment epithelium) RPE under normal and advancing age conditions and, identified SIRT2 and TRPM2 as molecular targets for the antioxidant and antiapoptotic actions of PRL in the RPE.

  18. TRPM2 has a role in the DNA damage response of T cell leukemia cells in a BCL-2 dependent manner

  19. Data show that HEK293 cells expressing low levels of receptor potential melastatin 2 (TRPM2) channel were more susceptible to silica nanoparticles (NPs) than those expressing high levels of TRPM2.

  20. This is expected to provide a basis for inhibiting TRPM2 for the improved treatment of breast cancer, which potentially includes treating breast tumors that are resistant to chemotherapy due to their evasion of apoptosis.

Zebrafish Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. cryo-electron microscopy structures of the zebrafish TRPM2 in the apo resting (closed) state and in the ADP-ribose/Ca(2+)-bound active (open) state, in which the characteristic NUDT9-H domains hang underneath the MHR1/2 domain; results provide an insight into the mechanism of activation of the TRPM channel family and define a framework for the development of therapeutic agents to treat neurodegenerative diseases

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. TRPM2 is a key agent in stress-induced depression and a possible target for treating depression.

  2. Cell culture, animal models, and patient samples established that TRPM2 expression/function is important for dopaminergic neuronal survival and is increased in neurotoxin models that mimic Parkinson's Disease.

  3. TRPM2 plays an important role in bacterial clearance in neutrophils, possibly by regulating elastase release

  4. Tumor cell-expressed transient receptor potential channel, melastatin subfamily type 2 (TRPM2) regulates neutrophil chemoattraction via chemokine CXCL2 (CXCL2).

  5. Results demonstrate a critical role for the TRPM2 channel in Abeta42-induced microglial activation and generation of TNF-alpha: PKC/NOX-mediated generation of ROS and activation of PARP-1 are required for Abeta42-induced TRPM2 channel activation and, furthermore, the PYK2/MEK/ERK signaling pathway as a positive feedback mechanism downstream of TRPM2 channel activation facilitates further activation of PARP-1 and TRPM2 ...

  6. Results reveal a novel, potentially druggable signalling pathway for FFA-induced beta-cell death. The cascade involves NOX-2-dependent production of ROS, activation of TRPM2 channels, rise in mitochondrial Zn(2+), Drp-1 recruitment and abnormal mitochondrial fission.

  7. High TRPM2 to trigger lysosomal membrane permeabilization and Zn(2+)-mediated mitochondrial fission.

  8. Trpm2 might promote hyperinflammation in Down Syndrome.

  9. Studied the role of transient receptor potential melastatin 2 (TRPM2) in activating caspase-1 and caspase-1-dependent pyroptosis in mouse BMDMs. Found TRPM2 knockout caused higher caspase-1 activation and pyrotopsis.

  10. Transient receptor potential melastatin-2 (TRPM2) in pituitary nerve terminals plays a role in oxytocin release. Temperature- enhanced oxytocin release by CD38 and TRPM2. TRPM2 might be involved in the process of CD38-regulated oxytocin release.

  11. this study shows that TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection

  12. Overexpression of TRPM2 channel prevented neutrophil transendothelial migration and vascular injury.

  13. These findings of this study suggest that TRPM2 channels play an essential role in mediating hypoxic-ischemic brain injury in neonatal mice.

  14. TRPM2 regulates phagosomal acidification, and is essential for the bacterial killing function of macrophages.

  15. Lysophosphatidylcholine induces intracellular Ca(2+) influx and increases phosphorylation of p38 MAPK via TRPM2, which in turn activates microglia.

  16. The current study demonstrated that a physiological concentration of adrenaline attenuates insulin release via coupling of alpha2A-adrenoceptor to cAMP/TRPM2 signaling.

  17. Trpm2 does not seem to play a major role in myeloid leukemogenesis. Additionally, loss of Trpm2 does not augment the cytotoxicity of standard AML chemotherapeutic agents.

  18. TRPM2 channels contribute to visceral nociception in response to noxious stimuli under normal conditions and visceral hypersensitivity in pathological conditions.

  19. this study demonstrates that the ion channel TRPM] is a temperature sensor in a subpopulation of hypothalamic neurons.

  20. Data show that macrophages from young mice showed lower transient receptor potential melastatin 2 (TRPM2) expression than those from senescent mice and had lower viability after silica nanoparticles (NPs) exposure than those from senescent ones.

TRPM2 profil antigène

Profil protéine

The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Gene names and symbols associated with TRPM2

  • transient receptor potential cation channel subfamily M member 2 (TRPM2) anticorps
  • transient receptor potential cation channel, subfamily M, member 2 (Trpm2) anticorps
  • transient receptor potential cation channel, subfamily M, member 2 (trpm2) anticorps
  • transient receptor potential cation channel subfamily C member 7 (TRPC7) anticorps
  • transient receptor potential cation channel subfamily M member 2 (trpm2) anticorps
  • transient receptor potential cation channel subfamily M member 2 (Trpm2) anticorps
  • 9830168K16Rik anticorps
  • C79133 anticorps
  • EREG1 anticorps
  • KNP3 anticorps
  • LTRPC2 anticorps
  • NUDT9H anticorps
  • NUDT9L1 anticorps
  • si:ch73-263b18.1 anticorps
  • Trp7 anticorps
  • TRPC7 anticorps
  • TRPM2 anticorps
  • Trpm2-predicted anticorps
  • Trrp7 anticorps

Protein level used designations for TRPM2

LTrpC-2 , estrogen-responsive element-associated gene 1 protein , long transient receptor potential channel 2 , transient receptor potential cation channel subfamily M member 2 , transient receptor potential channel 7 , transient receptor potential melastatin family 2 , transient receptor potential cation channel, subfamily M, member 2 , transient receptor potential cation channel, subfamily C, member 7 , transient receptor potential cation channel, subfamily C, member 7-like , transient receptor potential cation channel subfamily M member 2-like , transient receptor protein 7

GENE ID SPECIES
7226 Homo sapiens
294329 Rattus norvegicus
424835 Gallus gallus
470101 Pan troglodytes
508029 Bos taurus
799412 Danio rerio
100056810 Equus caballus
100083361 Ornithorhynchus anatinus
100124999 Xenopus (Silurana) tropicalis
100341596 Oryctolagus cuniculus
100479364 Ailuropoda melanoleuca
100556895 Anolis carolinensis
28240 Mus musculus
100720314 Cavia porcellus
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