anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 7 (TRPM7) Anticorps

The protein encoded by TRPM7 is both an ion channel and a serine/threonine protein kinase. De plus, nous expédions TRPM7 Protéines (7) et TRPM7 Kits (6) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
TRPM7 54822 Q96QT4
TRPM7 58800 Q923J1
TRPM7 679906  
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Top anti-TRPM7 Anticorps sur anticorps-enligne.fr

Showing 10 out of 196 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Souris Chèvre Inconjugué IHC, ELISA ABIN184611 staining (1 ug/ml) of Human Brain (hippocampus) lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg 6 to 7 Days
$429.87
Détails
Chien Chèvre Inconjugué EIA, IHC (p)   0.1 mg 11 Days
$478.50
Détails
Humain Lapin Inconjugué IHC (p), WB IHC-P Image TRPM7 antibody [C3], C-term detects TRPM7 protein at cytosol on human normal liver by immunohistochemical analysis. Sample: Paraffin-embedded human normal liver. TRPM7 antibody [C3], C-term , dilution: 1:250. WB Image Sample (30 ug of whole cell lysate) A: HCT116 5% SDS PAGE antibody diluted at 1:1000 100 μL 3 to 4 Days
$466.18
Détails
Humain Souris Inconjugué AA, ICC, IF, IHC, WB TrpM7 (S74 25), Human hippocampus. 100 μg 3 to 4 Days
$453.70
Détails
Humain Souris Inconjugué ICC, IHC, IHC (p), IP, WB Anti-TRPM7 antibody IHC staining of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN962067 concentration 10 ug/ml. 50 μg 11 to 14 Days
$639.83
Détails
Humain Souris FITC AA, ICC, IF, IHC, WB Western Blot analysis of Human Cell lysates showing detection of TrpM7 protein using Mouse Anti-TrpM7 Monoclonal Antibody, Clone S74-25 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-TrpM7 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. Immunohistochemistry analysis using Mouse Anti-TrpM7 Monoclonal Antibody, Clone S74-25 . Tissue: Brain Slice. Species: Mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-TrpM7 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Localization: Nuclear staining of both neurons and glia. 100 μg 3 to 4 Days
$504.40
Détails
Humain Souris APC AA, ICC, IF, IHC, WB Immunohistochemistry analysis using Mouse Anti-TrpM7 Monoclonal Antibody, Clone S74-25 . Tissue: Brain Slice. Species: Mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-TrpM7 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Localization: Nuclear staining of both neurons and glia. Immunohistochemistry analysis using Mouse Anti-TrpM7 Monoclonal Antibody, Clone S74-25 . Tissue: hippocampus. Species: Human. Fixation: Bouin's Fixative and paraffin-embedded. Primary Antibody: Mouse Anti-TrpM7 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. 100 μg 3 to 4 Days
$513.50
Détails
Humain Souris PerCP AA, ICC, IF, IHC, WB Immunohistochemistry analysis using Mouse Anti-TrpM7 Monoclonal Antibody, Clone S74-25 . Tissue: hippocampus. Species: Human. Fixation: Bouin's Fixative and paraffin-embedded. Primary Antibody: Mouse Anti-TrpM7 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Western Blot analysis of Human Cell lysates showing detection of TrpM7 protein using Mouse Anti-TrpM7 Monoclonal Antibody, Clone S74-25 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-TrpM7 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg 3 to 4 Days
$513.50
Détails
Humain Souris Atto 488 AA, ICC, IF, IHC, WB Immunohistochemistry analysis using Mouse Anti-TrpM7 Monoclonal Antibody, Clone S74-25 . Tissue: Brain Slice. Species: Mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-TrpM7 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Localization: Nuclear staining of both neurons and glia. Immunohistochemistry analysis using Mouse Anti-TrpM7 Monoclonal Antibody, Clone S74-25 . Tissue: hippocampus. Species: Human. Fixation: Bouin's Fixative and paraffin-embedded. Primary Antibody: Mouse Anti-TrpM7 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. 100 μg 3 to 4 Days
$514.80
Détails
Humain Souris Atto 565 AA, ICC, IF, IHC, WB Immunohistochemistry analysis using Mouse Anti-TrpM7 Monoclonal Antibody, Clone S74-25 . Tissue: Brain Slice. Species: Mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-TrpM7 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Localization: Nuclear staining of both neurons and glia. Immunohistochemistry analysis using Mouse Anti-TrpM7 Monoclonal Antibody, Clone S74-25 . Tissue: hippocampus. Species: Human. Fixation: Bouin's Fixative and paraffin-embedded. Primary Antibody: Mouse Anti-TrpM7 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. 100 μg 3 to 4 Days
$514.80
Détails

anti-TRPM7 Anticorps mieux référencés

  1. Mammalian Monoclonal TRPM7 Primary Antibody pour ISt, IHC - ABIN1305027 : Du, Xie, Zhang, Tsujikawa, Fusco, Silverman, Liang, Yue: TRPM7-mediated Ca2+ signals confer fibrogenesis in human atrial fibrillation. dans Circulation research 2010 (PubMed)
    Show all 10 Pubmed References

  2. Human Polyclonal TRPM7 Primary Antibody pour IHC (p), ELISA - ABIN544208 : Jhiang: The RET proto-oncogene in human cancers. dans Oncogene 2000 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal TRPM7 Primary Antibody pour IHC (p), ELISA - ABIN544207 : Cantrell: Phosphoinositide 3-kinase signalling pathways. dans Journal of cell science 2001 (PubMed)
    Show all 3 Pubmed References

  4. Polyclonal TRPM7 Primary Antibody pour IP, WB - ABIN540389 : Runnels, Yue, Clapham: TRP-PLIK, a bifunctional protein with kinase and ion channel activities. dans Science (New York, N.Y.) 2001 (PubMed)
    Show all 2 Pubmed References

  5. Mouse (Murine) Polyclonal TRPM7 Primary Antibody pour IHC (p), IHC - ABIN257037 : Nadler, Hermosura, Inabe, Perraud, Zhu, Stokes, Kurosaki, Kinet, Penner, Scharenberg, Fleig: LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability. dans Nature 2001 (PubMed)

  6. Human Polyclonal TRPM7 Primary Antibody pour ICC, IF - ABIN447301 : Yang, Cai, Zhang, Liu, Xu: Exosomes Secreted by Adipose-Derived Stem Cells Contribute to Angiogenesis of Brain Microvascular Endothelial Cells Following Oxygen-Glucose Deprivation In Vitro Through MicroRNA-181b/TRPM7 Axis. dans Journal of molecular neuroscience : MN 2018 (PubMed)

Plus d’anticorps contre TRPM7 partenaires d’interaction

Zebrafish Transient Receptor Potential Cation Channel, Subfamily M, Member 7 (TRPM7) interaction partners

  1. drTRPM7 has two protein domains that regulate inhibition by intracellular magnesium and nucleotides, and one domain that is concerned with sensing magnesium only.

  2. Zebrafish gene was identified that when mutated produces semi-viable offspring and that may serve as a model of human diseases that have both pigmentation and neurological symptoms.

  3. tct may represent a novel as well as selective regulator of melanoblast development within the neural crest lineage.

  4. Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern.

  5. TRPM7 plays a role within sensory neurons in modulating neutrotransmitter release at central synapses, similar to the role proprosed for mammalian TRPM7 at peripheral synapses.

  6. Trpm7 regulates exocrine pancreatic development via the Mg(2+)-sensitive Socs3a pathway.

  7. This study showed that stanniocalcin 1 (stc1)modulates cation levels in trpm7 mutants and in the wild type; levels of cations are restored to normal in trpm7 mutants when stc1 activity is blocked.

  8. Mutation in trpm7 leads to defective skeletogenesis and kidney stone formation.

  9. Cell death of melanophores in zebrafish trpm7 mutant embryos depends on melanin synthesis.

Human Transient Receptor Potential Cation Channel, Subfamily M, Member 7 (TRPM7) interaction partners

  1. This study analyses the phosphorylation patterns of the ion channel TRPM7 which is involved in a range of critical physiological functions.

  2. our results demonstrate that PGE2 activates TRPM7 via EP3/PKA signalling pathway, and that PGE2 enhances migration and proliferation of human glioblastoma cells by up-regulation of the TRPM7 channel.

  3. TRPM7 and MagT1 are upregulated in osteogenic differentiation and silencing either one accelerates osteogenic differentiation, partly through the activation of autophagy. .. These results underpin the contribution of magnesium, TRPM7 and MagT1 to autophagy and osteoblastogenesis.

  4. TRPM7 in CHBP-induced renoprotection upon ischemia reperfusion-related injury

  5. Several mechanosensitive ion channels expressed in dental sensory systems have been suggested as key players in the hydrodynamic theory, and TRPM7, which is abundant in the odontoblasts, and recently discovered PIEZO receptors are promising candidates.

  6. comparison of TRPM2 and TRPM7 ion channel gene expression and immunohistochemical staining in endometrial hyperplasia and endometrium adenocarcinoma

  7. TRPM7 silencing inhibited the epithelial-mesenchymal transition and metastasis of ovarian cancer by attenuating the calcium-related PI3k/AKT activation

  8. Astrocytic TRPM7 is a critical regulator of the formation of gliotic scar.

  9. Results demonstrate that TRPM7 expression is markedly higher in RCC cell lines and clinical samples and had a positive correlation with T status, tumor size, and poor patients' overall survival and progression-free survival.

  10. we have provided evidence that aberrant TRPM7 expression induces the cancer stem cell-like and metastatic phenotypes of aggressive human lung cancer cells through positive modulation of the Hsp90alpha/uPA/MMP2 signaling pathways and induction of pluripotency transcription factors.

  11. Data show that melastatin-related transient receptor potential member 7 (TRPM7)-K1648R mutant leads to disruption of protease or purinergic receptor-induced calcium release.

  12. Phosphorylation of S1565 within the exchange domain functions as a regulatory switch to control TRPM7 catalytic activity.

  13. These findings confirm that TRPM6 cannot be replaced by TRPM7, and that TRPM6/7 complexes and TRPM6/7-mediated Mg(2+) influx are indispensable in human epithelial colon cells.

  14. results identify SOX4 as a transcription factor that is uniquely sensitive to cellular tension and indicate that TRPM7 may contribute to breast cancer progression by tensional regulation of SOX4.

  15. Mg ions up-regulated the expression of Runx2 and alkaline phosphatase (ALP) through TRPM7/PI3K signalling pathway, which could significantly enhance the osteogenic activity of human osteoblasts.

  16. forms functional intracellular channels that mediate Zn2+ release from the lumen of a previously unrecognized population of vesicles during oxidative stress

  17. Malfunctions of TRPM7 are associated with anoxic neuronal death, cardiac fibrosis, tumor progression and macrothrombocytopenia. (Review)

  18. Authors observed that the expression of TRPM7 was significantly elevated in bladder cancer tissues compared with that noted in the adjacent non-tumor tissues. Furthermore, increased TRPM7 expression was significantly associated with recurrence, metastasis and prognosis.

  19. TRPM7 role in epithelial-mesenchymal transition, cell migration and invasion in prostate cancer cells

  20. our results in vitro and in vivo have revealed that the downregulation of TRPM7 could reduce the BCa cell proliferation, trigger cell cycle arrest and apoptosis. In conclusion, downregulated TRPM7 could reduce the activity of bladder cancer cells and induce cell apoptosis via ERK1/2 pathway.

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily M, Member 7 (TRPM7) interaction partners

  1. brain TRPM7 is important for having normal synaptic and cognitive functions under physiological, non-pathological conditions.

  2. Results demonstrate that a functional TRPM7 kinase supports robust SOCE, blastogenesis and proliferation, whereas its inactivation suppresses these cellular events.

  3. Study identified the TRP subfamily M member 7 (TRPM7) channel-kinase as a regulator of B cell activation; TRPM7 controls an essential process required for B cell affinity maturation and the production of high-affinity antibodies.

  4. TRPM7 in CHBP-induced renoprotection upon ischemia reperfusion-related injury

  5. These results indicate that the function of the TRPM7 kinase domain plays an important role in ameloblast differentiation, independent of TRPM7 channel activity, via phosphorylation of CREB.

  6. Internal Mg(2+)-, polyamine-, and pH-mediated inhibition of TRPM7 channels is not direct but, rather, reflects electrostatic screening and resultant disruption of PI(4,5)P2-channel interactions.

  7. findings suggest that TRPM7 channel activities play a key role in HG-associated ERS and cytotoxicity through an apoptosis-inducing signaling cascade involving HG, iNOS, TRPM7, ERS proteins, and caspases

  8. mTRPM6 and mTRPM7 contribute differentially to key functional characteristics of mTRPM6/7 complexes thereby functionally defining a new type of channel that remains active in the presence of physiological concentrations of [Mg2+]i and [Mg.ATP]i.

  9. The results point to a critical role for TRPM7's kinase activity in regulating proteasome-mediated turnover of the TRPM7 channel and controlling its cellular localization in polarized epithelial cells. Overall, these findings improve our understanding of the significance of TRPM7's kinase activity for functional regulation of its channel activity.

  10. Identify TRPM7 kinase as a key modulator of phospholipase C signaling and store-operated Ca(2+) entry in platelets with a role in controlling calcium responses in arterial thrombosis and stroke.

  11. TRPM7/miR-34a gene silencing could improve spatial cognitive function and protect hippocampal neurogenesis in mice with T1DM.

  12. The identification of TRPM7 and CaV3.2 as key mediators of Ca(2+) influx following fertilization.

  13. The enzymatic activity of TRPM7 is not essential for thymopoiesis, but is required for CD103 transcription and gut-homing of intra-epithelial lymphocytes. Mechanistically, TRPM7 kinase activity controls TGF-beta-induced CD103 expression and pro-inflammatory T helper 17, but not regulatory T, cell differentiation by modulating SMAD2.

  14. results provide a structural framework for understanding the TRPM1/3/6/7 subfamily and extend the knowledge base upon which to study the diversity and evolution of TRP channels.

  15. Transient receptor potential melastatin-like 7, a non-selective but Ca(2+)-conducting ion channel, mediates the cytosolic Ca(2+) elevations essential for lipopolysaccharide-induced macrophage activation

  16. The present results suggested that TRPM7 may be involved in Ca2+/Mg2+ homeostasis during chondrocyte hypertrophy, and contribute to endochondral ossification via interacting with the PI3KAkt signaling pathway.

  17. TRPM7 kinase activity regulates mast cell degranulation by changing its sensitivity to intracellular calcium.

  18. TRPM7 is part of a large cytoskeletal complex that may affect the malignant potential of tumor cells by regulating actomyosin dynamics and cell-matrix interactions.

  19. Inhibition of TRPM7 reduces calcium influx and accelerates the polarization of hippocampal neurons.

  20. our results suggest the differential roles of TRPM7 in endochondral and intramembranous ossification.

TRPM7 profil antigène

Profil protéine

The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam.

Gene names and symbols associated with TRPM7

  • transient receptor potential cation channel subfamily M member 7 (TRPM7) anticorps
  • transient receptor potential cation channel, subfamily M, member 7 (trpm7) anticorps
  • transient receptor potential cation channel, subfamily M, member 7 (Trpm7) anticorps
  • 2310022G15Rik anticorps
  • 4833414K03Rik anticorps
  • 5033407O22Rik anticorps
  • ALSPDC anticorps
  • cb495 anticorps
  • Chak anticorps
  • CHAK1 anticorps
  • Ltpr7 anticorps
  • LTrpC-7 anticorps
  • Ltrpc7 anticorps
  • Trp-plik anticorps
  • TRPM7 anticorps
  • TRPPLIK anticorps

Protein level used designations for TRPM7

transient receptor potential cation channel subfamily M member 7 , nutria , tct , touchtone , transient receptor potential melastatin 7 , transient receptor potential cation channel, subfamily M, member 7 , LTRPC ion channel family member 7 , LTrpC-7 , channel-kinase 1 , long transient receptor potential channel 7 , transient receptor potential-phospholipase C-interacting kinase , transient receptor potential M7 , transient receptor potential-related protein, ChaK

GENE ID SPECIES
427502 Gallus gallus
514642 Bos taurus
100034101 Equus caballus
280653 Danio rerio
100037693 Ovis aries
100228325 Taeniopygia guttata
100499162 Xenopus laevis
54822 Homo sapiens
478300 Canis lupus familiaris
58800 Mus musculus
679906 Rattus norvegicus
100169932 Sus scrofa
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