anti-Transmembrane Channel-Like 8 (TMC8) Anticorps

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. De plus, nous expédions TMC8 Protéines (7) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
TMC8 147138 Q8IU68
TMC8 688276  
TMC8 217356 Q7TN58
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Top anti-TMC8 Anticorps sur anticorps-enligne.fr

Showing 10 out of 69 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué WB WB Suggested Anti-TMC8 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: 721_B cell lysate 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human tonsil, using TMC8 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Connectez-vous pour afficher 2 to 3 Days
$302.50
Détails
Humain Lapin Inconjugué ELISA, IHC, WB 100 μL Connectez-vous pour afficher 16 Days
$181.73
Détails
Humain Lapin Inconjugué WB TMC8 Antibody (N-term) (ABIN658164) western blot analysis in NCI-H292 cell line lysates (35 µg/lane). This demonstrates the TMC8 antibody detected the TMC8 protein (arrow). 400 μL Connectez-vous pour afficher 10 to 11 Days
$385.00
Détails
Humain Lapin Inconjugué IHC, IHC (p), WB Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Connectez-vous pour afficher 11 to 14 Days
$484.00
Détails
Humain Lapin Inconjugué WB 50 μg Connectez-vous pour afficher 11 to 14 Days
$551.83
Détails
Humain Lapin Inconjugué ELISA, WB Western blot analysis of TMC8 using HeLa whole cell lysates 100 μL Connectez-vous pour afficher 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué WB 50 μg Connectez-vous pour afficher 11 to 14 Days
$551.83
Détails
Humain Lapin Inconjugué ELISA, WB   100 μg Connectez-vous pour afficher 15 to 19 Days
$527.03
Détails
Humain Lapin Inconjugué IHC, ELISA, WB   100 μg Connectez-vous pour afficher 15 to 19 Days
$527.03
Détails

anti-TMC8 Anticorps mieux référencés

  1. Human Polyclonal TMC8 Primary Antibody pour ELISA, WB - ABIN1002275 : Ramoz, Taïeb, Rueda, Montoya, Bouadjar, Favre, Orth: Evidence for a nonallelic heterogeneity of epidermodysplasia verruciformis with two susceptibility loci mapped to chromosome regions 2p21-p24 and 17q25. dans The Journal of investigative dermatology 2000 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal TMC8 Primary Antibody pour IHC, ELISA - ABIN1002274 : Ramoz, Rueda, Bouadjar, Montoya, Orth, Favre: Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis. dans Nature genetics 2002 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal TMC8 Primary Antibody pour IHC (p), WB - ABIN541721 : Lazarczyk, Pons, Mendoza, Cassonnet, Jacob, Favre: Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses. dans The Journal of experimental medicine 2008 (PubMed)
    Show all 2 Pubmed References

Plus d’anticorps contre TMC8 partenaires d’interaction

Human Transmembrane Channel-Like 8 (TMC8) interaction partners

  1. The relatively high proportion of EV patients without mutation in TMC6/8 indicates the existence of EV-causing mutations in additional, presently unknown gene(s). However, a homozygous TMC8 splice site mutation in our patients resulted in aberrant transcripts which cannot retain the healthy phenotype

  2. The present study did not show any significant association of the EVER1/2 polymorphisms (rs2290907and rs16970849) with cervical cancer.

  3. There were no differences in Ever2 SNPs between head and neck squamous cell carcinoma patients with human papilloma virus (HPV)-positive and HPV-negative tumors, and healthy controls.

  4. Findings suggest that SNPs in EVER2 may be involved in the development of premalignant skin lesions that harbour beta-HPV, perhaps giving rise to SCC tumours that have lost beta-HPV gene expression during progression.

  5. TMC6/EVER1 and TMC8/EVER2 are known to be involved in the development of EV.

  6. A common genetic variation in TMC8 is associated with high-risk HPV infection and head and neck squamous cell carcinoma etiology.

  7. We found a possible correlation between the EVER2 TT genotype and the development of AK, suggesting a potential role of this polymorphism in the development of AK.

  8. EV is also a rare autosomal recessive genodermatosis involving susceptibility to human papillomavirus (HPV) infections and squamous cell carcinoma, caused in most cases by homozygous mutations in EVER1 or EVER2.

  9. TMC8 was found to be localized in the endoplasmic reticulum (ER), where it inhibited receptor mediated Ca(2+) release, activation of Ano1 and volume regulated LRRC8-related Cl(-) currents.

  10. Expression of both EVER1 and EVER2 in B cells is activated immediately after Epstein-Barr virus (EBV) infection, whereas at later stages, it is strongly repressed by latent membrane protein 1-activated NF-kappaB signaling.

  11. Loss of the HPV-infection resistance EVER2 protein impairs NF-kappaB signaling pathways in keratinocytes.

  12. We report a case of Merkel cell polyomavirus detection in the skin of a patient with epidermodysplasia verruciformis (EDV) and a family history remarkable for an unusual inheritance pattern for EDV.

  13. Ever2 interacts with the N-terminal domain of TRADD, impairs the recruitment of TRAF2 and RIPK1 and promotes apoptosis.

  14. EVER2-deficient patients display mild T-cell abnormalities: a significant increase of memory CD4+ and effector memory CD8+ T cells, a bias of the T cell receptor Valphabeta and Vgammadelta repertoires and an increase of skin-homing CD4+ T-cell subsets.

  15. EVER proteins appear as key components of the activation-dependent regulation of Zn(2+) concentration in T cells. However, the impact of EVER-deficiency in T cells on EV pathogenesis remains to be elucidated

  16. study describes the presence of two previously unreported homozygous mutations in the EVER2 gene in two Italian epidermodysplasia verruciformis patients, each of whom have already developed more than 10 non-melanoma skin cancers

  17. Data support the involvement of the TMC6/8 region in cervix cancer susceptibility.

  18. Results underline the possible relevance of the EVER2/TMC8 single nucleotide polymorphism rs7208422 in influencing susceptibility to beta-papillomaviruses and their oncogenic potential.

  19. Mutations in EVER2 are associated with epidermodysplasia verruciformis.

  20. study reports a novel nonsense mutation of the TMC8 gene in Brazilian patients with epidermodysplasia verruciformis

TMC8 profil antigène

Profil protéine

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs.

Gene names and symbols associated with TMC8

  • transmembrane channel like 8 (TMC8) anticorps
  • transmembrane channel-like 8 (Tmc8) anticorps
  • transmembrane channel-like gene family 8 (Tmc8) anticorps
  • EV2 anticorps
  • Ever2 anticorps
  • EVIN2 anticorps
  • mFLJ00400 anticorps

Protein level used designations for TMC8

transmembrane channel-like 8 , FLJ00400 protein-like , transmembrane channel-like protein 8-like , epidermodysplasia verruciformis 2 , epidermodysplasia verruciformis protein 2 , transmembrane channel-like protein 8 , uncharacterized protein LOC688276 , epidermodysplasia verruciformis protein 2 homolog

GENE ID SPECIES
483342 Canis lupus familiaris
513813 Bos taurus
100031099 Monodelphis domestica
100443950 Pongo abelii
100478575 Ailuropoda melanoleuca
100596943 Nomascus leucogenys
100615612 Pan troglodytes
147138 Homo sapiens
688276 Rattus norvegicus
217356 Mus musculus
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