anti-Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Anticorps

The protein encoded by TDP1 is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. De plus, nous expédions TDP1 Protéines (14) et TDP1 Kits (3) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
TDP1 55775 Q9NUW8
TDP1 104884  
TDP1 314380 Q4G056
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Top anti-TDP1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 84 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB Host: Rabbit Target Name: Tdp1 Sample Type: Mouse Lung lysates Antibody Dilution: 1.0ug/ml 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-Tdp1 Antibody Titration: 1.0 ug/ml Positive Control: Mouse Brain 100 μL Connectez-vous pour afficher 2 to 3 Days
$319.00
Détails
Humain Souris Inconjugué EIA, IHC (p), WB 0.1 mL Connectez-vous pour afficher 6 to 8 Days
$390.50
Détails
Humain Souris Inconjugué ELISA, WB 50 μg Connectez-vous pour afficher 2 to 3 Days
$315.00
Détails
Humain Chèvre Inconjugué ELISA, WB   100 μg Connectez-vous pour afficher 6 to 7 Days
$429.84
Détails
Humain Souris Inconjugué ELISA, IHC, IHC (p), WB Human Small Intestine (formalin-fixed, paraffin-embedded) stained with  antibody ABIN462272 followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. Human Placenta (formalin-fixed, paraffin-embedded) stained with  antibody ABIN462272 followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. 50 μL Connectez-vous pour afficher 11 to 14 Days
$484.00
Détails
Humain Lapin Inconjugué IF, IP, WB Immunoprecipitation of TDP1 transfected lysate using anti-TDP1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with TDP1 purified MaxPab mouse polyclonal antibody (B01P) . Western Blot analysis of TDP1 expression in transfected 293T cell line by TDP1 MaxPab polyclonal antibody.Lane 1: TDP1 transfected lysate(68.40 KDa).Lane 2: Non-transfected lysate. 100 μL Connectez-vous pour afficher 11 to 12 Days
$425.71
Détails
Cobaye Lapin Inconjugué WB 100 μL Connectez-vous pour afficher 11 to 14 Days
$581.17
Détails
Humain Souris Inconjugué WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TDP1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-TDP1. 0.1 mL Connectez-vous pour afficher 2 to 3 Days
$482.90
Détails
Humain Lapin Inconjugué ICC, IF, IHC (p), WB ICC/IF Image Immunofluorescence analysis of methanol-fixed A431, using TDP1, antibody at 1:200 dilution. IHC-P Image Immunohistochemical analysis of paraffin-embedded human gastric, using TDP1, antibody at 1:100 dilution. 100 μL Connectez-vous pour afficher 3 to 4 Days
$466.18
Détails

anti-TDP1 Anticorps mieux référencés

  1. Human Polyclonal TDP1 Primary Antibody pour ELISA, WB - ABIN565920 : Katyal, el-Khamisy, Russell, Li, Ju, Caldecott, McKinnon: TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo. dans The EMBO journal 2007 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal TDP1 Primary Antibody pour IHC (p), IP - ABIN257087 : Perego, Cossa, Tinelli, Corna, Carenini, Gatti, De Cesare, Ciusani, Zunino, Luison, Canevari, Zaffaroni, Beretta: Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition. dans Biochemical pharmacology 2011 (PubMed)
    Show all 2 Pubmed References

Plus d’anticorps contre TDP1 partenaires d’interaction

Human Tyrosyl-DNA Phosphodiesterase 1 (TDP1) interaction partners

  1. HBZ suppresses TDP1 expression by inhibiting NRF-1 function in Adult T-cell leukemia cells.

  2. The results suggest that TDP1 and Artemis perform different functions in the repair of terminally blocked double-stranded breaks (DSBs) by the classical nonhomologous end joining pathway, and that whereas an Artemis deficiency prevents end joining of some DSBs, a TDP1 deficiency tends to promote DSB misjoining.

  3. The role of conserved residues Y204, F259, S400 and W590 of the catalytic groove of TDP1 protein DNA cleavage activity was analyzed.

  4. We found the rs942190 GG genotype of TDP1 to be associated with relatively poor survival among small-cell lung cancer patients. Further investigation is needed to confirm the result and to determine whether this genotype may be a predictive marker for treatment efficacy of DNA topoisomerase inhibitors

  5. this study identifies the importance of TDP1 as a novel determinant of response to CNDAC across various cancer types (especially non-small cell lung cancers), and demonstrates the differential involvement of BRCA2, PARP1, and TDP1 in the cellular responses to CNDAC, AraC, and CPT

  6. Data indicate that the initial step of tyrosyl-DNA phosphodiesterase 1 (Tdp1) interaction with DNA includes binding of Tdp1 to the DNA ends followed by the 3'-nucleosidase reaction.

  7. Data indicate a molecular basis for DNA 3'-end processing by tyrosyl-DNA phosphodiesterase (Tdp1).

  8. Expression of human Tdp1HisnucAla and Tdp1HisgabAsn mutants results in stabilization of the covalent TDP1-DNA intermediate and induces cytotoxicity.

  9. We show that two genes, TDP1, a tyrosyl-DNA-phosphdiesterase, and TAF12, an RNA polymerase II TATA-box binding factor, cause CIN when overexpressed in human cells. Using SDL screens in yeast, we identified a set of genes that when deleted specifically kill cells with high levels of Tdp1

  10. TDP1 participation in human non-homologous end joining (NHEJ) is mediated by interaction with XLF, and that TDP1-XLF interactions and subsequent NHEJ events are regulated by phosphorylation of TDP1-S81.

  11. Mutations in TDP1 and APTX have been linked to Spinocerebellar ataxia with axonal neuropathy (SCAN1) and Ataxia-ocular motor apraxia 1 (AOA1), respectively, while mutations in PNKP are considered to be responsible for Microcephaly with seizures (MCSZ) and Ataxia-ocular motor apraxia 4 (AOA4).

  12. The data obtained suggest that PARP1 and TDP1 bind in an antiparallel orientation; the N-terminus of the former protein interacts with the C-terminal domain of the latter.

  13. Tyrosyl-DNA-phosphodiesterase I (TDP1) participates in the removal and repair of stabilized-Top2alpha cleavage complexes in human cells.

  14. varying expression levels of TOP1 and TDP1 polypeptides in multiple colorectal cancer cell lines and in clinical colorectal cancer samples, are reported.

  15. both TOP1 and TDP1 were upregulated in the tumor tissue compared to the adjacent non-tumor tissue in non-small cell lung cancer tissue

  16. Density functional theory computations are used to acquire thermodynamic and kinetic data along the catalytic pathway, including the phosphoryl transfers of Tdp1 and subsequent hydrolysis.

  17. TDP1 plays a role during the early stages of mammalian NHEJ. TPD1 stimulated DNA binding by XLF. TDP1 also promoted DNA binding by Ku70/80 and stimulated DNA-PK activity.

  18. These findings suggest that the flexibility of Tdp1 active site residues may impair the resolution of mutant Tdp1 covalent phosphohistidyl intermediates

  19. This article summarizes and compares the biochemistry, functions, and post-translational regulation of TDP1 and TDP2, as well as the relevance of TDP1 and TDP2 as determinants of response to anticancer agents

  20. TDP1 and APTX take part in the mitochondrial DNA repair and are apparently being transported from the cell nucleus. (Review)

Mouse (Murine) Tyrosyl-DNA Phosphodiesterase 1 (TDP1) interaction partners

  1. These findings provide evidence for TDP1 as a novel mitochondrial enzyme.

  2. The interaction with Lig3alpha is promoted by serine 81 that is located within a putative S/TQ site in the N-terminus domain of TDP1.

  3. Data indicate that TDP1 is required for neural homeostasis and reveal a widespread requisite for TDP1 function in response to acutely elevated levels of DNA topoisomerase I (Top1)-associated DNA strand breaks.

  4. This study provides a direct demonstration that Tdp1 repairs Topo I covalent lesions in vivo and suggests that spinocerebellar ataxia with axonal neuropathy (SCAN1) arises from the recessive neomorphic mutation H493R.

  5. Tdp1(-/-) fibroblasts exhibited deficiencies in processing 3'-phosphotyrosyl single-strand breaks and 3'-phosphoglycolate double-strand breaks, but not 3'-phosphoglycolate single-strand breaks.

Arabidopsis thaliana Tyrosyl-DNA Phosphodiesterase 1 (TDP1) interaction partners

  1. the results of the present study demonstrate the structure-based function of AtTDP through which AtTDP can repair DNA strand breaks in plants

  2. AtTDP plays a clear role in the repair of topoisomerase I-DNA complexes.

TDP1 profil antigène

Profil protéine

The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.

Gene names and symbols associated with TDP1

  • tyrosyl-DNA phosphodiesterase 1 (TDP1) anticorps
  • tyrosyl-DNA Phosphodiesterase (Tdp1) (Tc00.1047053511191.10) anticorps
  • tyrosyl-DNA phosphodiesterase 1 (Tdp1) anticorps
  • tyrosyl-DNA phosphodiesterase 1 L homeolog (tdp1.L) anticorps
  • tyrosyl-DNA phosphodiesterase 1 (tdp1) anticorps
  • tyrosyl-DNA phosphodiesterase-like protein (TDP1) anticorps
  • tyrosyl-DNA phosphodiesterase 1 (PTRG_11198) anticorps
  • tyrosyl-DNA phosphodiesterase 1 (MCYG_02121) anticorps
  • tyrosyl-DNA phosphodiesterase 1 (MGYG_03035) anticorps
  • 2810481F14Rik anticorps
  • 4921509N21Rik anticorps
  • AI838772 anticorps
  • AW493413 anticorps
  • E430034L06Rik anticorps
  • F8M21.60 anticorps
  • F8M21_60 anticorps
  • MGC83708 anticorps
  • MLZ-501 anticorps
  • SCAN1 anticorps
  • TDP1 anticorps
  • tyrosyl-DNA phosphodiesterase 1 anticorps

Protein level used designations for TDP1

tyr-DNA phosphodiesterase 1 , tyrosyl-DNA Phosphodiesterase (Tdp1) , protein expressed in male leptotene and zygotene spermatocytes 501 , tyrosyl-DNA phodphodiesterase 1 , tyrosyl-DNA phosphodiesterase 1 , tyrosyl-DNA phosphodiesterase 1-like , Tyrosyl-DNA phosphodiesterase 1-like protein

GENE ID SPECIES
55775 Homo sapiens
3534433 Trypanosoma cruzi strain CL Brener
104884 Mus musculus
314380 Rattus norvegicus
423403 Gallus gallus
446983 Xenopus laevis
453096 Pan troglodytes
517053 Bos taurus
571485 Danio rerio
695338 Macaca mulatta
734106 Xenopus (Silurana) tropicalis
831369 Arabidopsis thaliana
6349511 Pyrenophora tritici-repentis Pt-1C-BFP
9229242 Arthroderma otae CBS 113480
10030819 Arthroderma gypseum CBS 118893
100388128 Callithrix jacchus
100432320 Pongo abelii
100593301 Nomascus leucogenys
100724667 Cavia porcellus
100062463 Equus caballus
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