anti-U2 Small Nuclear RNA Auxiliary Factor 1 (U2AF1) Anticorps

U2AF1 belongs to the splicing factor SR family of genes. De plus, nous expédions U2AF1 Protéines (8) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
U2AF1 108121 Q9D883
U2AF1 7307 Q01081
U2AF1 687575  
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Top anti-U2AF1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 64 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-U2AF1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: Fetal stomach 100 μL 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué ICC, IF, IP, IHC (p), WB WB Image Sample(30μg whole cell lysate) A: 293T B: A431 , C: H1299 D: HeLa S3 , E: Hep G2 , F: MOLT4 , G: Raji , 12% SDS PAGE antibody diluted at 1:1000 IP Image Immunoprecipitation of U2AF35 protein from 293T whole cell extracts using 5 μg of U2AF35 antibody, Western blot analysis was performed using U2AF35 antibody, EasyBlot anti-Rabbit IgG was used as a secondary reagent. 100 μL 3 to 4 Days
$466.18
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB 0.4 mL 6 to 8 Days
$484.00
Détails
Humain Lapin Inconjugué EIA, WB 0.4 mL 6 to 8 Days
$484.00
Détails
Humain Lapin Inconjugué IHC, WB Western blot analysis of extracts of various cells, using U2AF1 antibody. 100 μL 11 to 13 Days
$433.51
Détails
Roussette (Chauve-souris) Lapin Inconjugué WB 100 μL 11 to 14 Days
$551.83
Détails
Humain Lapin Inconjugué ELISA, IHC, WB Western blot analysis of Hela lysate, using U2AF1 antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6276464 at 1/100 staining Mouse brain tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué FACS, IHC (p), WB Western blot analysis of anti- in Ramos cell line lysates (35ug/lane). Formalin-fixed and paraffin-embedded human lung carcinoma reacted with , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL 2 to 3 Days
$515.63
Détails
Humain Lapin Inconjugué IHC (p), WB Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with U2AF1 antibody (Center S70), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of anti-U2AF1 Antibody (Center S70) in Ramos cell line lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Détails
Humain Lapin Inconjugué WB U2AF1 antibody used at 1 ug/ml to detect target protein. 50 μg 9 to 11 Days
$449.29
Détails

anti-U2AF1 Anticorps mieux référencés

  1. Human Polyclonal U2AF1 Primary Antibody pour ICC, IF - ABIN438948 : Wang, Wilson-Berry, Schedl, Hansen: TEG-1 CD2BP2 regulates stem cell proliferation and sex determination in the C. elegans germ line and physically interacts with the UAF-1 U2AF65 splicing factor. dans Developmental dynamics : an official publication of the American Association of Anatomists 2012 (PubMed)

  2. Human Polyclonal U2AF1 Primary Antibody pour ICC, IF - ABIN4363831 : Stadler, Fagerberg, Sivertsson, Oksvold, Zwahlen, Hallström, Lundberg, Uhlén: RNA- and antibody-based profiling of the human proteome with focus on chromosome 19. dans Journal of proteome research 2014 (PubMed)

Plus d’anticorps contre U2AF1 partenaires d’interaction

Mouse (Murine) U2 Small Nuclear RNA Auxiliary Factor 1 (U2AF1) interaction partners

  1. The U2AF35(S34F) mutation alters interaction with CFIm59, leading to increased use of a distal cleavage and polyadenylation site in the ATG7 pre-mRNA, decreasing levels of ATG7 protein and defective autophagy, ultimately leading to transformation.

  2. data support the impact of genes from the Abcg1-U2af1 region as modifiers of Tc1-dependent memory and locomotor phenotypes in Tc1 mouse model of Down syndrome.

  3. findings support the hypothesis that mutant U2AF1 alters downstream gene isoform expression, thereby contributing to abnormal hematopoiesis in patients with MDS

  4. this study establishes definitely the contribution of the Abcg1-U2af1 orthologous region to the DS etiology and suggests new modulatory pathways for learning and memory.

Human U2 Small Nuclear RNA Auxiliary Factor 1 (U2AF1) interaction partners

  1. lenalidomide response was adversely affected by U2AF1 mutations and high risk karyotype in MDS

  2. Langerhans Cell Histiocytosis is a clonally heterogenous disease, with multiple driver mutations ranging from BRAF mutations to TP53 and U2AF1 mutations likely playing a role in the pathogenesis.

  3. U2AF1 in association with its binding partner U2AF2, binds mature RNA in the cytoplasm and functions asa translational repressor

  4. Inhibition of IRAK4-L abrogates leukaemic growth, particularly in acute myeloid leukaemia (AML) cells with higher expression of the IRAK4-L isoform. Collectively, mutations in U2AF1 induce expression of therapeutically targetable 'active' IRAK4 isoforms and provide a genetic link to activation of chronic innate immune signalling in myelodysplastic syndromes and AML.

  5. U2AF1 mutation types in primary myelofibrosis.

  6. This meta-analysis indicates a positive effect of SF3B1 and an adverse prognostic effect of SRSF2, U2AF1, and ZRSR2 mutations in patients with myelodysplastic syndrome.

  7. Among 52 patients with U2AF1 mutations, 28 (54%) harbored S34 (25 S34F and 3 S34Y), 22 (42%) Q157 (16 Q157P and 6 Q157R), and two R156H

  8. Although 13 of 66 patients with the U2AF1 Q157 mutation had EZH2 mutations or deletions, no genetic alteration of EZH2 was found in the U2AF1 S34-mutated (n=32).

  9. Study thus points to an active role of U2AF1 S34F mutant protein in inducing cell cycle dysregulation and mitotic stress.

  10. The splicing effects of sudemycin and U2AF1 can be cumulative in cells exposed to both perturbations-drug and mutation, as compared with cells exposed to either alone.

  11. In univariable analysis, patients carrying mutations in DNMT3A, U2AF1, and EZH2 had worse overall and relapse-free survival.

  12. U2AF1 mutations are one of the earliest genetic events in myelodysplastic syndrome patients and different types of U2AF1 mutations have distinct clinical and biological characteristics.

  13. In summary, we provide insight into the underlying molecular mechanism of U2AF binding to 3' splice sites.

  14. data confirm MLL-PTD and, to a lesser extent, FLT3-ITD as common events in +11 AML.6, 7, 8 However, the high mutation frequencies of U2AF1 and genes involved in methylation (DNMT3A, IDH2) have hitherto not been reported in +11 AML

  15. this study characterized novel candidate pediatric T-cell acute lymphoblastic leukemia driver mutation in splicesome factor U2AF1

  16. U2AF35 missense mutation is associated with alternative 5' splice site that impacts splicing regulation in cancer.

  17. The frequently mutated SF3B1 residues contact the pre-mRNA splice site. Based on structural homology with other spliceosome subunits, and recent findings of altered RNA binding by mutant U2AF1 proteins, we suggest that affected U2AF1 residues also contact pre-mRNA.

  18. The aberrantly spliced target genes and deregulated cellular pathways associated with the commonly mutated splicing factor genes in myelodysplastic syndromes (SF3B1, SRSF2 and U2AF1) are being identified, illuminating the molecular mechanisms underlying the disease. (Review)

  19. infer that U2AF1 S34 mutations characterize a distinct subgroup of myelodysplastic syndrome

  20. Expression of U2AF1S34F in human hematopoietic progenitors results in impaired erythroid differentiation as a result of poor hemoglobinization and reduced growth of erythroid progenitors.

U2AF1 profil antigène

Profil protéine

This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with U2AF1

  • U2 small nuclear RNA auxiliary factor 1 (U2AF1) anticorps
  • CCHC-type zinc finger-containing protein (u2af1) anticorps
  • U2 small nuclear RNA auxiliary factor 1 (u2af1) anticorps
  • splicing factor U2AF 35 kDa subunit (LOC737227) anticorps
  • U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1 (U2af1) anticorps
  • U2 small nuclear RNA auxiliary factor 1 S homeolog (u2af1.S) anticorps
  • U2 small nuclear RNA auxiliary factor 1 (U2af1) anticorps
  • 35kDa anticorps
  • 2010107D16Rik anticorps
  • CHUNP6860 anticorps
  • DDBDRAFT_0218665 anticorps
  • DDBDRAFT_0233354 anticorps
  • DDB_0218665 anticorps
  • DDB_0233354 anticorps
  • FP793 anticorps
  • RN anticorps
  • RNU2AF1 anticorps
  • U2AF35 anticorps
  • U2AFBP anticorps
  • zgc:111896 anticorps

Protein level used designations for U2AF1

U2 small nuclear RNA auxiliary factor 1 , RNA recognition motif-containing protein RRM , RNA-binding region RNP-1 domain-containing protein , U2 snRNP auxiliary factor small subunit , U2(RNU2) small nuclear RNA auxiliary factor 1 , U2 auxiliary factor 35 kDa subunit , U2 small nuclear ribonucleoprotein auxiliary factor (U2AF),35 kDa , splicing factor U2AF 35 kDa subunit , U2 small nuclear RNA auxillary factor 1 , U2 small nuclear ribonucleoprotein auxillary factor, 35-KD subunit , U2(RNU2) small nuclear RNA auxiliary factor binding protein , splicing factor U2AF 35kDa subunit , U2snRNP auxiliary factor small subunit , uncharacterized protein LOC687575 , U2(RNU2) small nuclear RNA auxillary factor 1

GENE ID SPECIES
478422 Canis lupus familiaris
8624909 Dictyostelium discoideum AX4
733934 Xenopus (Silurana) tropicalis
737227 Pan troglodytes
108121 Mus musculus
7307 Homo sapiens
734926 Xenopus laevis
395370 Gallus gallus
512680 Bos taurus
687575 Rattus norvegicus
192328 Danio rerio
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