UbiA Prenyltransferase Domain Containing 1 Protéines (UBIAD1)

UBIAD1 encodes a protein thought to be involved in cholesterol and phospholipid metabolism. De plus, nous expédions UBIAD1 Anticorps (35) et UBIAD1 Kits (5) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
UBIAD1 29914 Q9Y5Z9
UBIAD1 71707 Q9DC60
Rat UBIAD1 UBIAD1 313706 D3ZG27
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Showing 3 out of 3 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 50 to 55 Days
$7,493.38
Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$5,262.31
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Wheat germ Humain GST tag 2 μg Connectez-vous pour afficher 11 to 12 Days
$338.33
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UBIAD1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour UbiA Prenyltransferase Domain Containing 1 (UBIAD1) partenaires d'interaction

Zebrafish UbiA Prenyltransferase Domain Containing 1 (UBIAD1) interaction partners

  1. Study identified a gene with important antioxidant features by analyzing a null allele of zebrafish ubiad1, called barolo (bar). bar mutants show specific cardiovascular failure due to oxidative stress and reactive oxygen species-mediated cellular damage.

Human UbiA Prenyltransferase Domain Containing 1 (UBIAD1) interaction partners

  1. The novel p.Thr120Arg is the fourth Schnyder corneal dystrophy-causing variant lying within the FARM motif of the UBIAD1 protein, which underlines a high importance of this motif for SCD pathogenesis.

  2. Although de novo occurrence of mutations in UBIAD1 is extremely rare, SCD should be considered in the differential diagnosis of bilateral corneal haze and/or crystal deposition, especially in children

  3. Silencing UBIAD1 further aggravates the deleterious effects rendered by Ang II, indicating that a normal or increased level of UBIAD1 may offer protection against the Ang IIinduced hypertrophic response and apoptosis.

  4. these findings disclose a novel sensing mechanism that allows for stringent metabolic control of intracellular trafficking of UBIAD1, which directly modulates reductase degradation and becomes disrupted in Schnyder corneal dystrophy (SCD).

  5. UBIAD1 or menaquinone-4 could decrease vascular cell differentiation and calcification, probably via its potent role of inversely modulating cellular cholesterol.

  6. The conserved domain I is a substrate recognition site that undergoes a structural change after substrate binding.

  7. Data show that sterols stimulate binding of prenyltransferase UBIAD1 to HMG CoA reductase, which is subject to sterol-accelerated, endoplasmic reticulum (ER)-associated degradation augmented by the nonsterol isoprenoid geranylgeraniol.

  8. results suggest that YY1 up-regulates UBIAD1 expression and UBIAD1 conversion activity through the UBIAD1 promoter

  9. N102S may also be a mutation hotspot in the Polish population, as in other previously reported populations.

  10. Golgi localization of UBIAD1 influences its tumor suppressant activity.

  11. Loss of TERE1 may contribute to the altered lipid metabolic phenotype associated with progression in renal clear cell carcinoma via an uncoupling of reactive oxygen species/nitric oxide and SXR signaling from apoptosis by elevation of cholesterol.

  12. A TERE1-TBL2 complex likely functions in oxidative/nitrosative stress, lipid metabolism, and SXR signaling pathways in its role as a tumor suppressor.

  13. Physical association of UBIAD1 with enzymes involved in cholesterol synthesis and storage, providing direct links between UBIAD1 and cholesterol metabolism that are likely relevant to Schnyder corneal dystrophy disease pathology.

  14. UBIAD1-mediated vitamin K2 synthesis is required for vascular endothelial cell survival and development.

  15. Findings identify UBIAD1 as a nonmitochondrial CoQ10-forming enzyme with specific cardiovascular protective function via the modulation of eNOS activity.

  16. The nonsynonymous mutation, N102S, in the UBIAD1 gene has been detected in in a four-generation Chinese family with Schnyder corneal dystrophy (SCD).

  17. the inhibitory effects of ectopic TERE1 expression on tumorigenic growth

  18. UBIAD1 encodes a menaquinone-4 biosynthetic enzyme that converts phylloquinone (PK) to menaquinone-4 (MK-4)

  19. Our newly reported UBIAD1 mutation suggests that central discoid corneal dystrophy (CDCD) is actually a variant of schnyder corneal dystrophy.

Mouse (Murine) UbiA Prenyltransferase Domain Containing 1 (UBIAD1) interaction partners

  1. UBIAD1 is responsible for vitamin K2 synthesis but may not be responsible for CoQ9 synthesis in mice.

Profil protéine UBIAD1

Profil protéine

This gene encodes a protein thought to be involved in cholesterol and phospholipid metabolism. Mutations in this gene are associated with Schnyder crystalline corneal dystrophy.

Gene names and symbols associated with UBIAD1

  • UbiA prenyltransferase domain containing 1 (UBIAD1)
  • UbiA prenyltransferase domain containing 1 (ubiad1)
  • UbiA prenyltransferase domain containing 1 (Ubiad1)
  • 1200002M06Rik Protéine
  • AI426463 Protéine
  • AW320947 Protéine
  • RGD1309588 Protéine
  • RP4-796F18.1 Protéine
  • SCCD Protéine
  • Tere1 Protéine
  • UBIAD1 Protéine
  • wu:fc30e12 Protéine

Protein level used designations for UBIAD1

UbiA prenyltransferase domain containing 1 , transitional epithelia response protein , ubiA prenyltransferase domain-containing protein 1 , bar , barolo , protein barolo , protein reddish , unm t31131 , unm_t31131 , UbiA prenyltransferase domain-containing protein 1 , transitional epithelial response protein 1

GENE ID SPECIES
457946 Pan troglodytes
100232196 Taeniopygia guttata
487446 Canis lupus familiaris
508501 Bos taurus
549292 Xenopus (Silurana) tropicalis
558410 Danio rerio
100467850 Ailuropoda melanoleuca
29914 Homo sapiens
71707 Mus musculus
313706 Rattus norvegicus
419456 Gallus gallus
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