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USP21 encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. De plus, nous expédions USP21 Protéines (4) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal USP21 Primary Antibody pour IHC (p), WB - ABIN387919
Puente, Sánchez, Overall, López-Otín: Human and mouse proteases: a comparative genomic approach. dans Nature reviews. Genetics 2003
Show all 4 Pubmed References
Cow (Bovine) Polyclonal USP21 Primary Antibody pour ELISA - ABIN451708
Gong, Kamitani, Millas, Yeh: Identification of a novel isopeptidase with dual specificity for ubiquitin- and NEDD8-conjugated proteins. dans The Journal of biological chemistry 2000
Data show that ubiquitin variants (Ubvs) that bind to USP2 (Montrer USP2 Anticorps) or USP21 contain a similar core functional epitope, or "hot spot," consisting mainly of positions that are conserved as the wild type sequence, but also some positions that prefer mutant sequences.
USP21 binds to the promoter region of IL-8 (Montrer IL8 Anticorps) and mediates transcriptional initiation, which regulates the stem-cell like property of human renal cell carcinoma (Montrer MOK Anticorps)
USP21 interacts with, deubiquitinates and stabilizes BRCA2 (Montrer BRCA2 Anticorps) to promote efficient RAD51 (Montrer RAD51 Anticorps) loading at DNA double-strand breaks.
a critical role of p38 (Montrer CRK Anticorps)-mediated USP21 phosphorylation in regulating STING-mediated antiviral functions and identifies p38 (Montrer CRK Anticorps)-USP21 axis as an important pathway that DNA virus adopts to avoid innate immunity responses.
USP21 recruits and stabilises Gli1 (Montrer GLI1 Anticorps) at the centrosome.
USP21 specifically regulates the Lys48-linked polyubiquitination and stability of NANOG
Data show that SUMOylated BANP (Montrer BANP Anticorps), E5R, and Nac1 (Montrer NACC1 Anticorps) (BEN) domain 3 (BEND3) stabilizes NoRC component TTF-1 (Montrer NKX2-1 Anticorps)-interacting protein 5 (Montrer CAPS Anticorps) (Tip5 (Montrer BAZ2A Anticorps))via association with ubiquitin specific protease 21 (USP21) debiquitinase
The protein stability of IL-33 (Montrer IL33 Anticorps) is maintained by USP21 through deubiquitination
Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3 (Montrer GATA3 Anticorps)
Study observed a reduction in the number of A549 cells developing a primary cilium upon serum starvation when USP21 was depleted with two independent siRNA oligos.
Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation
Overexpression of USP21 inhibited RNA virus-induced RIG-I (Montrer DDX58 Anticorps) polyubiquitination and RIG-I (Montrer DDX58 Anticorps)-mediated interferon (Montrer IFNA Anticorps) signaling, while USP21 deletion resulted in elevated RIG-I (Montrer DDX58 Anticorps) polyubiquitination, IRF3 (Montrer IRF3 Anticorps) phosphorylation, IFN production, and antiviral responses.
USP21 plays an important role in the down-regulation of TNFalpha (Montrer TNF Anticorps)-induced NF-kappaB (Montrer NFKB1 Anticorps) activation through deubiquitinating RIP1 (Montrer RALBP1 Anticorps).
This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants have been described.
ubiquitin specific peptidase 21
, Ubiquitin specific peptidase 21
, NEDD8-specific protease
, deubiquitinating enzyme 21
, ubiquitin carboxyl-terminal hydrolase 21
, ubiquitin specific protease 21
, ubiquitin thioesterase 21
, ubiquitin thiolesterase 21
, ubiquitin-specific processing protease 21
, ubiquitin-specific protease 16
, ubiquitin-specific-processing protease 21
, ubiquitin specific protease 23
, ubiquitin-specific protease 21