Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1) Kits ELISA

Vitamin K is essential for blood clotting but must be enzymatically activated. De plus, nous expédions VKORC1 Anticorps (29) et VKORC1 Protéines (4) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
VKORC1 79001 Q9BQB6
VKORC1 27973 Q9CRC0
VKORC1 309004 Q6TEK4
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Fournisseur Livraison Prix Détails
Humain 0.6 ng/mL 1.56 ng/mL - 100 ng/mL 96 Tests Connectez-vous pour afficher 13 to 16 Days
$736.84
Détails
Rat 0.62-40.0 ng/mL   96 Tests Connectez-vous pour afficher 2 to 3 Days
$713.90
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Souris
0.31-20.0 ng/mL   96 Tests Connectez-vous pour afficher 2 to 3 Days
$713.90
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Boeuf (Vache)
0.78-50 ng/mL   96 Tests Connectez-vous pour afficher 2 to 3 Days
$867.90
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Humain < 0.57 ng/mL 1.56 ng/mL - 100 ng/mL   96 Tests Connectez-vous pour afficher 11 to 18 Days
$810.17
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Plus Kits ELISA pour VKORC1 partenaires d'interaction

Human Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1) interaction partners

  1. The plasma S-warfarin (Cp(S)) time courses following the genotype-based dosing algorithms simulated using the PPK (Montrer GJB2 Kits ELISA) estimates showed African Americans with CYP2C9 (Montrer CYP2C9 Kits ELISA)*1/*1 and any of the VKORC1 genotypes would have an average Cp(S) at steady state 1.5-1.8 times higher than in Asians and whites.

  2. The final regression models for White and Black patients (Fig. 1) included age, weight, prosthetic valves, amiodarone use, CYP2C9 (Montrer CYP2C9 Kits ELISA)*3, and VKORC1 3673 G>A genotypes as covariates, whereas possession of CYP2C9 (Montrer CYP2C9 Kits ELISA)*2 and simvastatin use were retained in the final model for White, but not Black patients.

  3. No relationship between VKORC1 variants and clinical outcomes in elderly patients treated with vitamin K antagonists.

  4. Until the age of 19, weight has a far greater effect on Vitamin K antagonist dosing variation than VKORC1 and CYP2C9 (Montrer CYP2C9 Kits ELISA) polymorphisms. During the age of 20-40years, VKORC1 and CYP2C9 (Montrer CYP2C9 Kits ELISA) polymorphisms play a significant role.

  5. The VKORC1: c.-1639 G>A polymorphism is associated with aneurysms of the ascending aorta.

  6. 1639G4A polymorphism of the vitamin K epoxide reductase complex subunit 1 gene (VKORC1) is likely to be a new risk factor of Retinal Vascular Occlusion.

  7. Studied the association of CYP2C9 (Montrer CYP2C9 Kits ELISA)*2 (430C/T), *3 (1075A/C) and VKORC1 (-1639G/A) polymorphisms on warfarin dose requirements in patients post cardiac valve surgery. Found age and presence of CYP2C9 (Montrer CYP2C9 Kits ELISA) *2 allele significantly affect the daily dosage of warfarin during initiation of warfarin therapy after cardiac valve replacement surgery.

  8. The expression of VKOR in benign prostate epithelial cells, along with the association between a functional VKOR SNP and prostate cancer risk, suggests a possible role for VKOR in mediating the effect of warfarin on prostate cancer risk.

  9. analysis of VKORC1 AA-CYP2C9 (Montrer CYP2C9 Kits ELISA)*1*1 genotypes reveals dosing algorithms for vitamin K antagonists

  10. VKORC1 genotype influenced the likelihood of INR (Montrer INSR Kits ELISA) lability during warfarin maintenance in atrial fibrillation patients.

Mouse (Murine) Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1) interaction partners

  1. quantified mRNA levels for VKORC1, VKORC1L1, GGCX (Montrer GGCX Kits ELISA), and NQO1 (Montrer NQO1 Kits ELISA) and measured VKOR enzymatic activities in 29 different tissues

  2. OCN is gamma-carboxylated by the gamma-carboxylase (GGCX (Montrer GGCX Kits ELISA)) on three glutamic acid residues, a cellular process requiring reduction of vitamin K by a second enzyme, VKORC1.

  3. The involvement of VKORC1L1 in VKOR activity partly explains the low susceptibility of some extrahepatic tissues to vitamin K antagonists.

  4. molecular cloning [VKORC1]

  5. The genetic basis for resistance to anticoagulants lies in mutations in Vkorc1.

  6. An analysis of novel mutations show that the VKORC1 gene is the main target for spontaneous mutations conferring warfarin resistance.

  7. Each VKORC1 T-allele present in patients from the Rotterdam anticoagulation therapy study is shown to decrease the required acenocoumarol dosage by 5.1 mg/week.

VKORC1 profil antigène

Antigen Summary

Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described.

Gene names and symbols associated with VKORC1

  • vitamin K epoxide reductase complex, subunit 1 (VKORC1) anticorps
  • vitamin K epoxide reductase complex subunit 1 (vkorc1) anticorps
  • vitamin K epoxide reductase complex, subunit 1 (vkorc1) anticorps
  • vitamin K epoxide reductase complex subunit 1 (VKORC1) anticorps
  • Vitamin-K epoxide reductase (Vkor) anticorps
  • vitamin K epoxide reductase complex, subunit 1 (Vkorc1) anticorps
  • BP1071 anticorps
  • CG33544 anticorps
  • D7Wsu86e anticorps
  • Dmel\\CG33544 anticorps
  • EDTP308 anticorps
  • HDC06808 anticorps
  • IMAGE3455200 anticorps
  • MGC89620 anticorps
  • MST134 anticorps
  • MST576 anticorps
  • VKCFD2 anticorps
  • VKOR anticorps
  • VKORC1 anticorps

Protein level used designations for VKORC1

phylloquinone epoxide reductase , vitamin K1 epoxide reductase (warfarin-sensitive) , vitamin K epoxide reductase complex, subunit 1 , CG33544-PA , Vkor-PA , vitamin K dependent clotting factors deficiency 2 , vitamin K epoxide reductase complex subunit 1 , vitamin K1 2,3-epoxide reductase subunit 1 , Warfarin resistance

GENE ID SPECIES
404205 Gallus gallus
446034 Takifugu rubripes
448775 Xenopus (Silurana) tropicalis
479775 Canis lupus familiaris
3346188 Drosophila melanogaster
79001 Homo sapiens
27973 Mus musculus
309004 Rattus norvegicus
445422 Bos taurus
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