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wdr83 encodes a member of the WD-40 protein family. De plus, nous expédions WD Repeat Domain 83 Anticorps (83) et beaucoup plus de produits pour cette protéine.
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Morg1 facilitates Par6-aPKC binding to Crb3 for definition of apical identity of epithelial cells.
WDR83 and DHPS were capable of forming an RNA duplex at overlapping 3' untranslated regions and this duplex increased their mutual stability, which was required for the bidirectional regulation.
Includes the identification of this protein in C complex spliceosomes.
Functional characterization of the homologous rat gene.
Component of a modular scaffold system that participates in the regulation of agonist-specific ERK signaling.
Morg1 expression is reduced in human brain tissue with ischemic damage. Reactive astrocytes in the surrounding brain tissue showed strong Morg1 expression.
MORG1 heterozygosity protects against histological renal damage and shows anti-inflammatory effects in a murine endotoxemia model.
High MORG1 expression is associated with diabetic nephropathy.
heterozygous deficiency protects against kidney injury induced by systemic hypoxia
this study shows for the first time in various renal cells that ANG II modulates Morg1 expression and HIF-1alpha transcriptional activity via cell type-specific mechanisms, demonstrating a novel mechanism by which ANG II may contribute to renal disease.
The major finding of this study is that Morg1+/- mice are partially protected from cerebral ischemia and reperfusion injury in comparison to the WT (Morg1+/+) animals
Morg1 may be a novel therapeutic target to limit renal injury after ischemia-reperfusion
This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants.
MAPK organizer 1
, WD repeat domain-containing protein 83
, mitogen-activated protein kinase organizer 1
, MAPK cascade scaffold protein
, WD repeat protein Morg1
, Mitogen-activated protein kinase organizer 1