serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) Kits ELISA

Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. De plus, nous expédions serine Palmitoyltransferase, Long Chain Base Subunit 1 Anticorps (119) et serine Palmitoyltransferase, Long Chain Base Subunit 1 Protéines (12) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
SPTLC1 10558 O15269
SPTLC1 268656 O35704
Anti-Rat SPTLC1 SPTLC1 361213  
Comment commander chez anticorps-enligne
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Commandez enligne
  • orders@anticorps-enligne.fr

Top serine Palmitoyltransferase, Long Chain Base Subunit 1 Kits ELISA sur anticorps-enligne.fr

Showing 3 out of 7 products:

Catalogue No. Reactivité Sensibilité Gamme Images Quantité Fournisseur Livraison Prix Détails
Souris 0.054 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Connectez-vous pour afficher 13 to 16 Days
$757.89
Détails
Humain 27 ng/mL 78.12 pg/mL - 5000 pg/mL   96 Tests Connectez-vous pour afficher 15 to 17 Days
$908.41
Détails
Humain < 0.188 ng/mL 0.313 ng/mL - 20 ng/mL   96 Tests Connectez-vous pour afficher 11 to 18 Days
$810.17
Détails

Plus Kits ELISA pour serine Palmitoyltransferase, Long Chain Base Subunit 1 partenaires d'interaction

Arabidopsis thaliana serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) interaction partners

  1. Findings indicate that AtORM1 and AtORM2 mediation of serine palmitoyltransferase (SPT) activity differentially regulates functionally distinct ceramide synthase activities as part of a broader sphingolipid homeostatic regulatory network.

  2. The roles of the LCB2a and LCB2b subunits in sphingolipid biosyntesis in A. thaliana were studied.

Human serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) interaction partners

  1. Therefore, SPT may be an attractive therapeutic anti-cancer drug target for which compound-2 may be a promising new drug.

  2. Hereditary sensory and autonomic neuropathy type 1 mutations in SPTLC1 have distinct biochemical properties, which allowed for the prediction of the clinical symptoms on the basis of the plasma sphingoid base profile.

  3. This study describe aberrant morphology of SPTLC1C133W Dorsal Root Ganglia characterized by increased neurite growth, branching, and expression of p-ERM at neuronal growth cones.

  4. A novel SPTLC2-S384F variant in 2 unrelated HSAN1 families resulted in elevated plasma 1-deoxySL levels. Expression of this mutant in HEK293 cells increased 1-deoxySL formation. The substrate specificity is affected by phosphorylation at this position.

  5. Therefore, Ser331 in SPTLC1 is a crucial amino acid, which characterizes the Hereditary sensory and autonomic neuropathy type I phenotype

  6. SPTLC1 mutations cause mitochondrial abnormalities and ER stress in HSN1 cells.

  7. Endoplasmic reticulum-resident human protein serine palmitoyltransferase long chain-1 (SPTLC1) is phosphorylated at Tyr(164) by the tyrosine kinase ABL.

  8. The p.CYS133Trp mutation in SPTLC1 is the most common cause of hereditary and autonomic neuropathy in the United Kingdom population.

  9. SPTLC1 mutations p.S331F and p.A352V result in a reduction of serine palmitoyltransferase activity in vitro and are associated with increased levels of the deoxysphingoid in patients' plasma samples.

  10. Hereditary sensory neuropathy type 1 is caused by a gain of function mutation in SPTLC1 which causes the accumulation of two neurotoxic sphingolipids

  11. an increase in transepidermal water loss is an obligatory trigger for the upregulation of serine palmitoyltransferase mRNA expression in human epidermis

  12. A novel missense mutation in exon 13 of the SPTLC1 gene (c.1160G-->C; p.G387A) in twin sisters with a severe HSN I phenotype is reported.

  13. SPT1 aggregation preceded cell death in hypoxia and represents the first evidence of acute protein aggregation during hypoxia.

  14. Transgenic mouse lines that ubiquitously overexpress either wild-type or mutant SPTLC1 represent a novel mouse model of peripheral neuropathy and confirm the link between mutant SPT and neuronal dysfunction.

  15. Results suggest that functional serine palmitoyltransferase is not a dimer, but a higher organized complex, composed of three distinct subunits (SPTLC1, SPTLC2 and SPTLC3) with a molecular mass of 480 kDa.

  16. serine palmitoyltransferase and ceramidase are two major ceramide metabolizing enzymes that may have roles in psoriatic epidermis

  17. SPTLC1 mutational analysis reveals the C133W mutation, a mutation common in British hereditary sensory and autonomic neuropathy type I patients.

  18. Physical interaction of ABCA1 and SPTLC1 results in reduction of ABCA1 activity and that inhibition of this interaction produces enhanced cholesterol efflux.

  19. we show that none of the HSAN I mutations interferes with serine palmitoyltransferase complex formation; the G387A mutation is most likely not directly associated with Hereditary sensory neuropathy type 1

  20. SPT subunit 1 might be present also in focal adhesions and the nucleus.

Mouse (Murine) serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) interaction partners

  1. mice with an adipocyte-specific deletion of Sptlc1 show that de novo sphingolipid biosynthesis is required for adipocyte cell viability and normal metabolic function and that reduced de novo sphingolipid biosynthesis within adipocytes is associated with adipocyte death, adipose tissue remodeling, and metabolic dysfunction

  2. Data suggest that overexpression of serine palmitoyltransferase (Sptlc1, serine palmitoyltransferase long chain base subunit 1) to elevate de novo sphingolipid biosynthesis induces autophagy in the liver.

  3. Both Sptlc1 and Sptlc2 interactions are necessary for Serine palmitoyl-CoA transferase (SPT) activity in vivo and SPT activity directly influences plasma sphingolipid levels

  4. The expression and activities of SPT in mouse liver increased significantly following fumonisin B1 treatment

  5. Physical interaction of ABCA1 and SPTLC1 results in reduction of ABCA1 activity and that inhibition of this interaction produces enhanced cholesterol efflux.

  6. Sptlc1 deficient mice absorb less cholesterol.

serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) profil antigène

Antigen Summary

Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified.

Gene names and symbols associated with SPTLC1

  • serine palmitoyltransferase 1 (SPT1) anticorps
  • serine palmitoyltransferase 1 (AFUA_6G00300) anticorps
  • Serine palmitoyltransferase 1 (PAS_FragB_0040) anticorps
  • serine palmitoyltransferase long chain base subunit 1 (SPTLC1) anticorps
  • serine palmitoyltransferase, long chain base subunit 1 (sptlc1) anticorps
  • serine palmitoyltransferase, long chain base subunit 1 L homeolog (sptlc1.L) anticorps
  • serine palmitoyltransferase, long chain base subunit 1 (Sptlc1) anticorps
  • serine palmitoyltransferase long chain base subunit 1 (Sptlc1) anticorps
  • Afu6g00300 anticorps
  • ATSPT1 anticorps
  • AW552086 anticorps
  • C77762 anticorps
  • E030036H05 anticorps
  • HSAN1 anticorps
  • HSN1 anticorps
  • LBC1 anticorps
  • Lcb1 anticorps
  • RGD1306617 anticorps
  • serine palmitoyltransferase 1 anticorps
  • Spt1 anticorps
  • SPTI anticorps
  • wu:fc75h04 anticorps
  • wu:fp41c08 anticorps
  • zgc:112247 anticorps

Protein level used designations for SPTLC1

Serine palmitoyltransferase 1 , LCB 1 , SPT 1 , long chain base biosynthesis protein 1 , serine C-palmitoyltransferase , serine palmitoyltransferase 1 , serine-palmitoyl-CoA transferase 1 , fc75h04 , fp41c08 , SPT1 , serine palmitoyltransferase subunit 1 , Long chain base biosynthesis protein 1 , Serine-palmitoyl-CoA transferase 1 , serine palmitoyltransferase LCB1 subunit

GENE ID SPECIES
824039 Arabidopsis thaliana
3503652 Aspergillus fumigatus Af293
8196517 Komagataella pastoris GS115
10558 Homo sapiens
553981 Danio rerio
432022 Xenopus laevis
426145 Gallus gallus
484192 Canis lupus familiaris
614165 Bos taurus
268656 Mus musculus
361213 Rattus norvegicus
100689326 Cricetulus griseus
Fournisseurs de qualité sélectionnés pour serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) Kits ELISA
Avez-vous cherché autre chose?