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Petrey, Flanagan-Steet, Johnson, Fan, De la Rosa, Haskins, Nairn, Moremen, Steet: Excessive activity of cathepsin K is associated with cartilage defects in a zebrafish model of mucolipidosis II. dans Disease models & mechanisms 2012
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McComb, Shutinoski, Thurston, Cessford, Kumar, Sad: Cathepsins limit macrophage necroptosis through cleavage of Rip1 kinase. dans Journal of immunology (Baltimore, Md. : 1950) 2014
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Human Cathepsin S Kit ELISA pour Sandwich ELISA - ABIN415099
Gu, Lü, Chen, Zhou, Song, Jin, Liu: Relationship between plasma cathepsin S and cystatin C levels and coronary plaque morphology of mild to moderate lesions: an in vivo study using intravascular ultrasound. dans Chinese medical journal 2010
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Mouse (Murine) Cathepsin S Kit ELISA pour Sandwich ELISA - ABIN415776
Steubl, Kumar, Tato, Mulay, Larsson, Lind, Risérus, Renders, Heemann, Carlsson, Ärnlöv, Anders: Circulating cathepsin-S levels correlate with GFR decline and sTNFR1 and sTNFR2 levels in mice and humans. dans Scientific reports 2017
Overall, these results indicate that exploitation of the cathepsin S activity in MPS tissues can be utilized to substantially lower non-target accumulation, suggesting this is a promising approach for the development of diagnostic and radiotherapeutic nanomedicine platforms.
polymorphism of rs7534124 and rs1136774 in cathepsin S promoter may decrease the susceptibility of asthma in a Chinese Han population
cathepsin S mRNA (CTSS), which encodes a cysteine protease (Montrer CTSB Kits ELISA) associated with angiogenesis and atherosclerosis, is highly edited in human endothelial cells. RNA editing enables the recruitment of the stabilizing RNA-binding protein (Montrer PTBP1 Kits ELISA) human antigen R (HuR (Montrer ELAVL1 Kits ELISA); encoded by ELAVL1 (Montrer ELAVL1 Kits ELISA)) to the 3' UTR (Montrer UTS2R Kits ELISA) of the CTSS transcript, thereby controlling CTSS mRNA stability and expression.
levels of cathepsin S and hsCRP observed in women who later developed breast cancer may provide prognostic information regarding tumor development and need to be evaluated in prospective studies.
p41 (Montrer EPB41 Kits ELISA) fragment is also shown to reduce the secretion of interleukin-12 (IL-12 (Montrer IL12A Kits ELISA)/p70 (Montrer ANXA6 Kits ELISA)) during the subsequent maturation of treated dendritic cells.
shedding of surface proteins by extracellular cathepsins impacts intracellular signaling as demonstrated for regulation of Ras GTPase (Montrer RACGAP1 Kits ELISA) activity.
the essential role of autophagy-regulated early ROS (Montrer ROS1 Kits ELISA) in triggering late apoptotic signaling
Cathepsin S cleaves near the N-terminus of PAR2 (Montrer F2RL1 Kits ELISA) to expose a novel tethered ligand, KVDGTS.
Increased plasma CTSS concentration is associated with atherogenesis.
results identify Cat-S as a biased agonist of PAR2 (Montrer F2RL1 Kits ELISA) that causes PAR2 (Montrer F2RL1 Kits ELISA)- and TRPV4 (Montrer TRPV4 Kits ELISA)-dependent inflammation and pain.
the roles of CTSB (Montrer CTSB Kits ELISA)/S and SIRT1 (Montrer SIRT1 Kits ELISA) in the regulation of hepatic inflammation using primary parenchymal and non-parenchymal hepatic cell types and cell lines.
Cathepsin S activity controls injury-related vascular remodeling via TLR2 (Montrer TLR2 Kits ELISA)/p38MAPK (Montrer MAPK14 Kits ELISA)/PI3K/Akt (Montrer AKT1 Kits ELISA)/p-HDAC6 (Montrer HDAC6 Kits ELISA) signaling pathway.
Loss of Rab3D (Montrer RAB3D Kits ELISA) from secretory vesicles, leading to disproportionate Rab27 (Montrer RAB27A Kits ELISA)-to-Rab3D (Montrer RAB3D Kits ELISA) activity, may contribute to the enhanced release of cathepsin S in tears of patients with Sjogren's syndrome.
Ctss induction during muscular dystrophy is a pathologic event that partially underlies disease pathogenesis, and its inhibition might serve as a new therapeutic strategy in Duchenne muscular dystrophy (Montrer DMD Kits ELISA).
Demonstrate the utility of intracellular caspase 1 (Montrer CASP1 Kits ELISA) and extracellular CTSS proteolytic activities as surrogate biomarkers of lysosomal rupture and acute inflammation.
Fluorogen substrate, Mca-GRWPPMGLPWE-Lys (Montrer LYZ Kits ELISA)(Dnp)-DArg-NH2 can detect CTSS activities in mouse antigen presenting cells.
Data show that cathepsins S (CatS) regulates CCL2 (Montrer CCL2 Kits ELISA) chemokine (Montrer CCL1 Kits ELISA) expression by modulation of CD74 (Montrer CD74 Kits ELISA) antigen processing.
Cathepsin S activates MrgprC11 (Montrer MRGPRX1 Kits ELISA) and evokes receptor-dependent scratching in mice.
cathepsin S deficiency alters the balance between adipocyte and osteoblast differentiation, increases bone turnover, and changes bone microarchitecture. Therefore, bone and fat metabolisms should be monitored when using cathepsin S inhibitors clinically
These results, together with those previously reported for other genes of this family, suggest that cathepsin genes play a role in defining economically important traits in pigs.
The cathepsin S deserves further evaluation as therapeutic targets to develop disease modifying drugs to treat Alzheimer's disease.
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
, cathepsin S, gene 1
, Cathepsin S
, Cat S